Nanoscale iodized oil emulsion: A useful tracer for pretreatment sentinel node detection using ct lymphography in a normal canine gastric model

Joon Seok Lim, Junjeong Choi, Jyewon Song, Yong Eun Chung, Soo Jeong Lim, Sang Kil Lee, Woo Jin Hyung

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Pretreatment identification of the sentinel lymph nodes (SLNs) in gastric cancer patientsmay have great advantages for minimally invasive treatment. No reliable method for the detection of SLNs during the pretreatment period in gastric cancer has been established. The aim of this study was to determine whether computed tomographic (CT) lymphography using nanoscale iodized oil emulsion via endoscopic submucosal injection can visualize LNs. Methods: Five dogs underwent CT lymphography after endoscopic submucosal injection of 2 ml of a nanoscale iodized oil emulsion. CT images were taken before and 30, 90, and 210 min after contrast injection. Intraoperative SLN detection was performed using endoscopically injected indocyanine green lymphography for comparison. Results Computed tomographic lymphography with nanoscale iodized oil emulsion enabled the visualization of 19 enhanced LNs (mean = 3.8/dog, range = 3-6) with a 100% SLN detection rate. The locations of the SLNs were the lesser curvature (n = 7), greater curvature (n = 1), infrapyloric (n = 3), and left gastric (n = 8) areas. Contrast enhancement of SLNs continuously increased and peaked after 210 min at 142.4 ± 42.3 HU. No green LNs were visualized in the three locations that were detected by CT lymphography. However, no additional LNs were visualized using the dye method. The concordance rate based on the LNs between the SLNs on CT lymphography and the green LNs using the ICG method was 84% (16/19), whereas the concordance rate of the stations identified by CT lymphography and the dye method was 78.6% (11/14). Conclusions: Computed tomographic lymphography using nanoscale iodized oil emulsion is a promising tool for preoperative SLN detection for early gastric cancer if the biological safety of the nanoscale iodized oil emulsion can be established.

Original languageEnglish
Pages (from-to)2267-2274
Number of pages8
JournalSurgical endoscopy
Volume26
Issue number8
DOIs
Publication statusPublished - 2012 Aug

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Ethiodized Oil
Lymphography
Emulsions
Canidae
Stomach
Stomach Neoplasms
Injections
Coloring Agents
Dogs
Indocyanine Green
cyhalothrin
Sentinel Lymph Node
Safety

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

@article{b4eed2b59c5d4fac875c5e9ef3c0a74b,
title = "Nanoscale iodized oil emulsion: A useful tracer for pretreatment sentinel node detection using ct lymphography in a normal canine gastric model",
abstract = "Background: Pretreatment identification of the sentinel lymph nodes (SLNs) in gastric cancer patientsmay have great advantages for minimally invasive treatment. No reliable method for the detection of SLNs during the pretreatment period in gastric cancer has been established. The aim of this study was to determine whether computed tomographic (CT) lymphography using nanoscale iodized oil emulsion via endoscopic submucosal injection can visualize LNs. Methods: Five dogs underwent CT lymphography after endoscopic submucosal injection of 2 ml of a nanoscale iodized oil emulsion. CT images were taken before and 30, 90, and 210 min after contrast injection. Intraoperative SLN detection was performed using endoscopically injected indocyanine green lymphography for comparison. Results Computed tomographic lymphography with nanoscale iodized oil emulsion enabled the visualization of 19 enhanced LNs (mean = 3.8/dog, range = 3-6) with a 100{\%} SLN detection rate. The locations of the SLNs were the lesser curvature (n = 7), greater curvature (n = 1), infrapyloric (n = 3), and left gastric (n = 8) areas. Contrast enhancement of SLNs continuously increased and peaked after 210 min at 142.4 ± 42.3 HU. No green LNs were visualized in the three locations that were detected by CT lymphography. However, no additional LNs were visualized using the dye method. The concordance rate based on the LNs between the SLNs on CT lymphography and the green LNs using the ICG method was 84{\%} (16/19), whereas the concordance rate of the stations identified by CT lymphography and the dye method was 78.6{\%} (11/14). Conclusions: Computed tomographic lymphography using nanoscale iodized oil emulsion is a promising tool for preoperative SLN detection for early gastric cancer if the biological safety of the nanoscale iodized oil emulsion can be established.",
author = "Lim, {Joon Seok} and Junjeong Choi and Jyewon Song and Chung, {Yong Eun} and Lim, {Soo Jeong} and Lee, {Sang Kil} and Hyung, {Woo Jin}",
year = "2012",
month = "8",
doi = "10.1007/s00464-012-2170-2",
language = "English",
volume = "26",
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issn = "0930-2794",
publisher = "Springer New York",
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Nanoscale iodized oil emulsion : A useful tracer for pretreatment sentinel node detection using ct lymphography in a normal canine gastric model. / Lim, Joon Seok; Choi, Junjeong; Song, Jyewon; Chung, Yong Eun; Lim, Soo Jeong; Lee, Sang Kil; Hyung, Woo Jin.

In: Surgical endoscopy, Vol. 26, No. 8, 08.2012, p. 2267-2274.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nanoscale iodized oil emulsion

T2 - A useful tracer for pretreatment sentinel node detection using ct lymphography in a normal canine gastric model

AU - Lim, Joon Seok

AU - Choi, Junjeong

AU - Song, Jyewon

AU - Chung, Yong Eun

AU - Lim, Soo Jeong

AU - Lee, Sang Kil

AU - Hyung, Woo Jin

PY - 2012/8

Y1 - 2012/8

N2 - Background: Pretreatment identification of the sentinel lymph nodes (SLNs) in gastric cancer patientsmay have great advantages for minimally invasive treatment. No reliable method for the detection of SLNs during the pretreatment period in gastric cancer has been established. The aim of this study was to determine whether computed tomographic (CT) lymphography using nanoscale iodized oil emulsion via endoscopic submucosal injection can visualize LNs. Methods: Five dogs underwent CT lymphography after endoscopic submucosal injection of 2 ml of a nanoscale iodized oil emulsion. CT images were taken before and 30, 90, and 210 min after contrast injection. Intraoperative SLN detection was performed using endoscopically injected indocyanine green lymphography for comparison. Results Computed tomographic lymphography with nanoscale iodized oil emulsion enabled the visualization of 19 enhanced LNs (mean = 3.8/dog, range = 3-6) with a 100% SLN detection rate. The locations of the SLNs were the lesser curvature (n = 7), greater curvature (n = 1), infrapyloric (n = 3), and left gastric (n = 8) areas. Contrast enhancement of SLNs continuously increased and peaked after 210 min at 142.4 ± 42.3 HU. No green LNs were visualized in the three locations that were detected by CT lymphography. However, no additional LNs were visualized using the dye method. The concordance rate based on the LNs between the SLNs on CT lymphography and the green LNs using the ICG method was 84% (16/19), whereas the concordance rate of the stations identified by CT lymphography and the dye method was 78.6% (11/14). Conclusions: Computed tomographic lymphography using nanoscale iodized oil emulsion is a promising tool for preoperative SLN detection for early gastric cancer if the biological safety of the nanoscale iodized oil emulsion can be established.

AB - Background: Pretreatment identification of the sentinel lymph nodes (SLNs) in gastric cancer patientsmay have great advantages for minimally invasive treatment. No reliable method for the detection of SLNs during the pretreatment period in gastric cancer has been established. The aim of this study was to determine whether computed tomographic (CT) lymphography using nanoscale iodized oil emulsion via endoscopic submucosal injection can visualize LNs. Methods: Five dogs underwent CT lymphography after endoscopic submucosal injection of 2 ml of a nanoscale iodized oil emulsion. CT images were taken before and 30, 90, and 210 min after contrast injection. Intraoperative SLN detection was performed using endoscopically injected indocyanine green lymphography for comparison. Results Computed tomographic lymphography with nanoscale iodized oil emulsion enabled the visualization of 19 enhanced LNs (mean = 3.8/dog, range = 3-6) with a 100% SLN detection rate. The locations of the SLNs were the lesser curvature (n = 7), greater curvature (n = 1), infrapyloric (n = 3), and left gastric (n = 8) areas. Contrast enhancement of SLNs continuously increased and peaked after 210 min at 142.4 ± 42.3 HU. No green LNs were visualized in the three locations that were detected by CT lymphography. However, no additional LNs were visualized using the dye method. The concordance rate based on the LNs between the SLNs on CT lymphography and the green LNs using the ICG method was 84% (16/19), whereas the concordance rate of the stations identified by CT lymphography and the dye method was 78.6% (11/14). Conclusions: Computed tomographic lymphography using nanoscale iodized oil emulsion is a promising tool for preoperative SLN detection for early gastric cancer if the biological safety of the nanoscale iodized oil emulsion can be established.

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