Nanoscale patterns of oligonucleotides formed by electrohydrodynamic jet printing with applications in biosensing and nanomaterials assembly

Jang-Ung Park, Jung Heon Lee, Ungyu Paik, Yi Lu, John A. Rogers

Research output: Contribution to journalArticle

142 Citations (Scopus)

Abstract

The widespread use of DNA in microarrays for applications in biotechnology, combined with its promise in programmed nanomaterials assembly, unusual electronic devices, and other areas has created interest in methods for patterning DNA with high spatial resolution. Techniques based on thermal or piezoelectric inkjet printing are attractive due to their noncontacting nature and their compatibility with diverse materials and substrate types; their modest resolution (i.e., 10-20 μm) represents a major limitation for certain systems. Here we demonstrate the use of an operationally similar printing approach that exploits electrohydrodynamic forces, rather than thermal or acoustic energy, to eject DNA inks through fine nozzles, in a controlled fashion. This DNA printer is capable of resolution approaching 100 nm. A range of experiments on patterns of DNA formed with this printer demonstrates its key features. Example applications in DNA-directed nanoparticle assembly and DNA aptamer-based biosensing illustrate two representative uses of the patterns that can be formed.

Original languageEnglish
Pages (from-to)4210-4216
Number of pages7
JournalNano Letters
Volume8
Issue number12
DOIs
Publication statusPublished - 2008 Dec 1

Fingerprint

Electrohydrodynamics
electrohydrodynamics
oligonucleotides
Oligonucleotides
Nanostructured materials
printing
Printing
DNA
deoxyribonucleic acid
assembly
printers
Nucleotide Aptamers
Biotechnology
Microarrays
biotechnology
Ink
inks
Nozzles
thermal energy
compatibility

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

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Nanoscale patterns of oligonucleotides formed by electrohydrodynamic jet printing with applications in biosensing and nanomaterials assembly. / Park, Jang-Ung; Lee, Jung Heon; Paik, Ungyu; Lu, Yi; Rogers, John A.

In: Nano Letters, Vol. 8, No. 12, 01.12.2008, p. 4210-4216.

Research output: Contribution to journalArticle

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