Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer

Ryuichi Ideta, Fumitaka Tasaka, Woo Dong Jang, Nobuhiro Nishiyama, Guo Dong Zhang, Atsushi Harada, Yasuo Yanagi, Yasuhiro Tamaki, Takuzo Aida, Kazunori Kataoka

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164 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensrtizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.

Original languageEnglish
Pages (from-to)2426-2431
Number of pages6
JournalNano letters
Volume5
Issue number12
DOIs
Publication statusPublished - 2005 Dec 1

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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    Ideta, R., Tasaka, F., Jang, W. D., Nishiyama, N., Zhang, G. D., Harada, A., Yanagi, Y., Tamaki, Y., Aida, T., & Kataoka, K. (2005). Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. Nano letters, 5(12), 2426-2431. https://doi.org/10.1021/nl051679d