Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer

Ryuichi Ideta; Fumitaka Tasaka; Woo Dong Jang; Nobuhiro Nishiyama; Guo Dong Zhang; Atsushi Harada; Yasuo Yanagi; Yasuhiro Tamaki; Takuzo Aida; Kazunori Kataoka

doi:10.1021/nl051679d

Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer

Ryuichi Ideta, Fumitaka Tasaka, Woo Dong Jang, Nobuhiro Nishiyama, Guo Dong Zhang, Atsushi Harada, Yasuo Yanagi, Yasuhiro Tamaki, Takuzo Aida, Kazunori Kataoka

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

183 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensrtizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.

Original language	English
Pages (from-to)	2426-2431
Number of pages	6
Journal	Nano letters
Volume	5
Issue number	12
DOIs	https://doi.org/10.1021/nl051679d
Publication status	Published - 2005 Dec

All Science Journal Classification (ASJC) codes

Bioengineering
Chemistry(all)
Materials Science(all)
Condensed Matter Physics
Mechanical Engineering

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10.1021/nl051679d

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title = "Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer",

abstract = "Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensrtizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.",

author = "Ryuichi Ideta and Fumitaka Tasaka and Jang, {Woo Dong} and Nobuhiro Nishiyama and Zhang, {Guo Dong} and Atsushi Harada and Yasuo Yanagi and Yasuhiro Tamaki and Takuzo Aida and Kazunori Kataoka",

year = "2005",

month = dec,

doi = "10.1021/nl051679d",

language = "English",

volume = "5",

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journal = "Nano Letters",

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T1 - Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer

AU - Ideta, Ryuichi

AU - Tasaka, Fumitaka

AU - Jang, Woo Dong

AU - Nishiyama, Nobuhiro

AU - Zhang, Guo Dong

AU - Harada, Atsushi

AU - Yanagi, Yasuo

AU - Tamaki, Yasuhiro

AU - Aida, Takuzo

AU - Kataoka, Kazunori

PY - 2005/12

Y1 - 2005/12

N2 - Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensrtizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.

AB - Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensrtizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.

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JO - Nano Letters

JF - Nano Letters

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ER -

Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer

Abstract

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