Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer

Ryuichi Ideta, Fumitaka Tasaka, Woo Dong Jang, Nobuhiro Nishiyama, Guo Dong Zhang, Atsushi Harada, Yasuo Yanagi, Yasuhiro Tamaki, Takuzo Aida, Kazunori Kataoka

Research output: Contribution to journalArticle

161 Citations (Scopus)

Abstract

Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensrtizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.

Original languageEnglish
Pages (from-to)2426-2431
Number of pages6
JournalNano letters
Volume5
Issue number12
DOIs
Publication statusPublished - 2005 Dec 1

Fingerprint

angiogenesis
Photodynamic therapy
Photosensitizing Agents
Photosensitizers
Photochemical reactions
Micelles
nanotechnology
Nanotechnology
therapy
Agglomeration
degeneration
occlusion
photochemical reactions
lesions
micelles
formulations

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

Cite this

Ideta, Ryuichi ; Tasaka, Fumitaka ; Jang, Woo Dong ; Nishiyama, Nobuhiro ; Zhang, Guo Dong ; Harada, Atsushi ; Yanagi, Yasuo ; Tamaki, Yasuhiro ; Aida, Takuzo ; Kataoka, Kazunori. / Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. In: Nano letters. 2005 ; Vol. 5, No. 12. pp. 2426-2431.
@article{089e63f5444a4bcebe0dde244d1caf72,
title = "Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer",
abstract = "Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensrtizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.",
author = "Ryuichi Ideta and Fumitaka Tasaka and Jang, {Woo Dong} and Nobuhiro Nishiyama and Zhang, {Guo Dong} and Atsushi Harada and Yasuo Yanagi and Yasuhiro Tamaki and Takuzo Aida and Kazunori Kataoka",
year = "2005",
month = "12",
day = "1",
doi = "10.1021/nl051679d",
language = "English",
volume = "5",
pages = "2426--2431",
journal = "Nano Letters",
issn = "1530-6984",
publisher = "American Chemical Society",
number = "12",

}

Ideta, R, Tasaka, F, Jang, WD, Nishiyama, N, Zhang, GD, Harada, A, Yanagi, Y, Tamaki, Y, Aida, T & Kataoka, K 2005, 'Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer', Nano letters, vol. 5, no. 12, pp. 2426-2431. https://doi.org/10.1021/nl051679d

Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer. / Ideta, Ryuichi; Tasaka, Fumitaka; Jang, Woo Dong; Nishiyama, Nobuhiro; Zhang, Guo Dong; Harada, Atsushi; Yanagi, Yasuo; Tamaki, Yasuhiro; Aida, Takuzo; Kataoka, Kazunori.

In: Nano letters, Vol. 5, No. 12, 01.12.2005, p. 2426-2431.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nanotechnology-based photodynamic therapy for neovascular disease using a supramolecular nanocarrier loaded with a dendritic photosensitizer

AU - Ideta, Ryuichi

AU - Tasaka, Fumitaka

AU - Jang, Woo Dong

AU - Nishiyama, Nobuhiro

AU - Zhang, Guo Dong

AU - Harada, Atsushi

AU - Yanagi, Yasuo

AU - Tamaki, Yasuhiro

AU - Aida, Takuzo

AU - Kataoka, Kazunori

PY - 2005/12/1

Y1 - 2005/12/1

N2 - Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensrtizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.

AB - Photodynamic therapy (PDT) for exudative age-related macular degeneration (AMD) was evaluated using a supramolecular nanomedical device, that is, a novel dendritic photosensrtizer (DP) encapsulated by a polymeric micelle formulation. The characteristic dendritic structure of the DP prevents aggregation of its core sensitizer, thereby inducing a highly effective photochemical reaction. With its highly selective accumulation on choroidal neovascularization (CNV) lesions, this treatment resulted in a remarkably efficacious CNV occlusion with minimal unfavorable phototoxicity.

UR - http://www.scopus.com/inward/record.url?scp=30644472892&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30644472892&partnerID=8YFLogxK

U2 - 10.1021/nl051679d

DO - 10.1021/nl051679d

M3 - Article

C2 - 16351191

AN - SCOPUS:30644472892

VL - 5

SP - 2426

EP - 2431

JO - Nano Letters

JF - Nano Letters

SN - 1530-6984

IS - 12

ER -