Nasolacrimal stent with shape memory as an advanced alternative to silicone products

Ju Young Park, Jung Bok Lee, Woo Beom Shin, Mi Lan Kang, Yong Cheol Shin, Deok Hyeon Son, Se Won Yi, Jeong Kee Yoon, Ji Young Kim, Jae Sang Ko, Chang Soo Kim, Jin Sook Yoon, Hak Joon Sung

Research output: Contribution to journalArticle

Abstract

Epiphora is the overflow of tears typically caused by obstruction or occlusion of the nasolacrimal duct. More attention is required to address this global health issue owing to the increase in air pollution. Implantation of a silicone stent is the preferred treatment for epiphora; however, introducing a silicone stent into a narrow duct with complex geometry is challenging as it requires guidance by a sharp metal needle. Additionally, silicone can cause adverse reactions such as biofilm formation and tear flow resistance due to its extreme hydrophobicity. To overcome these problems, in this study we developed a new type of biocompatible shape memory polymer (SMP) stent with elasticity capacity for self-expansion. First, SMPs in the form of x%poly(ε-caprolactone)-co–y%poly(glycidyl methacrylate) (x%PCL–y%PGMA) were synthesized via ring opening polymerization by varying the molar ratio of PCL (x%) and PGMA (y%). Second, the shape memory and mechanical properties were tuned by controlling the crosslinking degree and concentration of x%PCL–y%PGMA solution to produce a test type of SMP stent. Lastly, this 94%PCL–06%PGMA stent exhibited more standout critical functions in a series of in vitro and in vivo experiments such as a cell growth-supporting level of biocompatibility with nasal epithelial cells without significant inflammatory responses, better resistance to biofilm formation, and more efficient capacity to drain tear than the silicone control. Overall, 94%PCL–06%PGMA can be suggested as a superior alternative to the currently used materials for nasolacrimal stents. Statement of significance: Silicone intubation (stenting) has been widely used to treat nasolacrimal duct obstruction, however, it can cause adverse clinical effects such as bacterial infection; presents procedural challenges because of the curved nasolacrimal duct structure; and shows poor drainage efficiency stemming from the highly hydrophobic nature of silicone. In this work, we describe an innovative shape memory polymer (SMP) as a superior alternative to conventional silicone-based materials for nasolacrimal duct intubation. We demonstrate the clear advantages of the SMP over conventional silicone, including a much higher drainage capacity and superior resistance to bacterial infection.

Original languageEnglish
Pages (from-to)273-284
Number of pages12
JournalActa Biomaterialia
Volume101
DOIs
Publication statusPublished - 2020 Jan 1

Fingerprint

Stents
Silicones
Shape memory effect
Nasolacrimal Duct
Ducts
Polymers
Tears
Lacrimal Apparatus Diseases
Biofilms
Bacterial Infections
Intubation
Drainage
Ring opening polymerization
Air Pollution
Elasticity
Cell growth
Hydrophobicity
Air pollution
Hydrophobic and Hydrophilic Interactions
Biocompatibility

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Biomaterials
  • Biochemistry
  • Biomedical Engineering
  • Molecular Biology

Cite this

Park, J. Y., Lee, J. B., Shin, W. B., Kang, M. L., Shin, Y. C., Son, D. H., ... Sung, H. J. (2020). Nasolacrimal stent with shape memory as an advanced alternative to silicone products. Acta Biomaterialia, 101, 273-284. https://doi.org/10.1016/j.actbio.2019.11.001
Park, Ju Young ; Lee, Jung Bok ; Shin, Woo Beom ; Kang, Mi Lan ; Shin, Yong Cheol ; Son, Deok Hyeon ; Yi, Se Won ; Yoon, Jeong Kee ; Kim, Ji Young ; Ko, Jae Sang ; Kim, Chang Soo ; Yoon, Jin Sook ; Sung, Hak Joon. / Nasolacrimal stent with shape memory as an advanced alternative to silicone products. In: Acta Biomaterialia. 2020 ; Vol. 101. pp. 273-284.
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abstract = "Epiphora is the overflow of tears typically caused by obstruction or occlusion of the nasolacrimal duct. More attention is required to address this global health issue owing to the increase in air pollution. Implantation of a silicone stent is the preferred treatment for epiphora; however, introducing a silicone stent into a narrow duct with complex geometry is challenging as it requires guidance by a sharp metal needle. Additionally, silicone can cause adverse reactions such as biofilm formation and tear flow resistance due to its extreme hydrophobicity. To overcome these problems, in this study we developed a new type of biocompatible shape memory polymer (SMP) stent with elasticity capacity for self-expansion. First, SMPs in the form of x{\%}poly(ε-caprolactone)-co–y{\%}poly(glycidyl methacrylate) (x{\%}PCL–y{\%}PGMA) were synthesized via ring opening polymerization by varying the molar ratio of PCL (x{\%}) and PGMA (y{\%}). Second, the shape memory and mechanical properties were tuned by controlling the crosslinking degree and concentration of x{\%}PCL–y{\%}PGMA solution to produce a test type of SMP stent. Lastly, this 94{\%}PCL–06{\%}PGMA stent exhibited more standout critical functions in a series of in vitro and in vivo experiments such as a cell growth-supporting level of biocompatibility with nasal epithelial cells without significant inflammatory responses, better resistance to biofilm formation, and more efficient capacity to drain tear than the silicone control. Overall, 94{\%}PCL–06{\%}PGMA can be suggested as a superior alternative to the currently used materials for nasolacrimal stents. Statement of significance: Silicone intubation (stenting) has been widely used to treat nasolacrimal duct obstruction, however, it can cause adverse clinical effects such as bacterial infection; presents procedural challenges because of the curved nasolacrimal duct structure; and shows poor drainage efficiency stemming from the highly hydrophobic nature of silicone. In this work, we describe an innovative shape memory polymer (SMP) as a superior alternative to conventional silicone-based materials for nasolacrimal duct intubation. We demonstrate the clear advantages of the SMP over conventional silicone, including a much higher drainage capacity and superior resistance to bacterial infection.",
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Park, JY, Lee, JB, Shin, WB, Kang, ML, Shin, YC, Son, DH, Yi, SW, Yoon, JK, Kim, JY, Ko, JS, Kim, CS, Yoon, JS & Sung, HJ 2020, 'Nasolacrimal stent with shape memory as an advanced alternative to silicone products', Acta Biomaterialia, vol. 101, pp. 273-284. https://doi.org/10.1016/j.actbio.2019.11.001

Nasolacrimal stent with shape memory as an advanced alternative to silicone products. / Park, Ju Young; Lee, Jung Bok; Shin, Woo Beom; Kang, Mi Lan; Shin, Yong Cheol; Son, Deok Hyeon; Yi, Se Won; Yoon, Jeong Kee; Kim, Ji Young; Ko, Jae Sang; Kim, Chang Soo; Yoon, Jin Sook; Sung, Hak Joon.

In: Acta Biomaterialia, Vol. 101, 01.01.2020, p. 273-284.

Research output: Contribution to journalArticle

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T1 - Nasolacrimal stent with shape memory as an advanced alternative to silicone products

AU - Park, Ju Young

AU - Lee, Jung Bok

AU - Shin, Woo Beom

AU - Kang, Mi Lan

AU - Shin, Yong Cheol

AU - Son, Deok Hyeon

AU - Yi, Se Won

AU - Yoon, Jeong Kee

AU - Kim, Ji Young

AU - Ko, Jae Sang

AU - Kim, Chang Soo

AU - Yoon, Jin Sook

AU - Sung, Hak Joon

PY - 2020/1/1

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N2 - Epiphora is the overflow of tears typically caused by obstruction or occlusion of the nasolacrimal duct. More attention is required to address this global health issue owing to the increase in air pollution. Implantation of a silicone stent is the preferred treatment for epiphora; however, introducing a silicone stent into a narrow duct with complex geometry is challenging as it requires guidance by a sharp metal needle. Additionally, silicone can cause adverse reactions such as biofilm formation and tear flow resistance due to its extreme hydrophobicity. To overcome these problems, in this study we developed a new type of biocompatible shape memory polymer (SMP) stent with elasticity capacity for self-expansion. First, SMPs in the form of x%poly(ε-caprolactone)-co–y%poly(glycidyl methacrylate) (x%PCL–y%PGMA) were synthesized via ring opening polymerization by varying the molar ratio of PCL (x%) and PGMA (y%). Second, the shape memory and mechanical properties were tuned by controlling the crosslinking degree and concentration of x%PCL–y%PGMA solution to produce a test type of SMP stent. Lastly, this 94%PCL–06%PGMA stent exhibited more standout critical functions in a series of in vitro and in vivo experiments such as a cell growth-supporting level of biocompatibility with nasal epithelial cells without significant inflammatory responses, better resistance to biofilm formation, and more efficient capacity to drain tear than the silicone control. Overall, 94%PCL–06%PGMA can be suggested as a superior alternative to the currently used materials for nasolacrimal stents. Statement of significance: Silicone intubation (stenting) has been widely used to treat nasolacrimal duct obstruction, however, it can cause adverse clinical effects such as bacterial infection; presents procedural challenges because of the curved nasolacrimal duct structure; and shows poor drainage efficiency stemming from the highly hydrophobic nature of silicone. In this work, we describe an innovative shape memory polymer (SMP) as a superior alternative to conventional silicone-based materials for nasolacrimal duct intubation. We demonstrate the clear advantages of the SMP over conventional silicone, including a much higher drainage capacity and superior resistance to bacterial infection.

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