Natural history of HBeAg negative chronic hepatitis B virus infection: a cohort study

Chang Mo Moon, doyoung kim, Ki Jun Song, Ja Kyung Kim, Hyun Woong Lee, Jung Min Lee, Ki Tae Yoon, Yong Han Paik, Dong Ki Kim, KwangHyub Han, Chae Yoon Chon, Young Myoung Moon, SangHoon Ahn

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Abstract

BACKGROUND/AIMS: The long-term virologic and biochemical changes in patients with HBeAg negative HBV infection, especially in Asia, remain unclear. To address this issue, we conducted a 3 year- retrospective, cohort study. METHODS: A total of 157 patients with HBeAg negative HBV infection who were monitored without treatment were reviewed between January 1999 and March 2004. Those patients were followed up every 3 months with liver function tests and serologic tests. All patients were stratified into 3 groups; inactive carrier (IC), viremic carrier (VC) and chronic hepatitis (CH). Serum HBV DNA was measured by a hybridization assay (sensitivity: 1.4 x 10(5)) genomes/mL, Digene Diagnostics, Silver Spring, USA). RESULTS: The median age of enrolled patients was 42.7 years (M:F=2.3:1). By single time-point observations, the 3 year-cohort prevalence of HBeAg negative CH varied from 12.7 to 35.8% (median 20.7%) HBeAg negative CH was accumulated over time (P=0.002) and transition rates among three groups after 3 years of follow-up are as follows: IC to CH, 6.0%; IC to VC, 4.1%; VC to CH, 23.2%. VC seems to be a disease state in the middle of transition from IC to CH. CONCLUSIONS: We demonstrated the dynamic changing patterns of HBeAg negative CH with time, of which the change from IC or VC to CH was dominant.

Original languageEnglish
Pages (from-to)163-172
Number of pages10
JournalThe Korean journal of hepatology
Volume12
Issue number2
Publication statusPublished - 2006 Jan 1

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Hepatitis B e Antigens
Chronic Hepatitis B
Virus Diseases
Chronic Hepatitis
Natural History
Hepatitis B virus
Cohort Studies
Liver Function Tests
Serologic Tests
Infection
Silver
Retrospective Studies
Genome
DNA
Serum

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Moon, Chang Mo ; kim, doyoung ; Song, Ki Jun ; Kim, Ja Kyung ; Lee, Hyun Woong ; Lee, Jung Min ; Yoon, Ki Tae ; Paik, Yong Han ; Kim, Dong Ki ; Han, KwangHyub ; Chon, Chae Yoon ; Moon, Young Myoung ; Ahn, SangHoon. / Natural history of HBeAg negative chronic hepatitis B virus infection : a cohort study. In: The Korean journal of hepatology. 2006 ; Vol. 12, No. 2. pp. 163-172.
@article{e5f6f59faa8f42858d866dcad05b2fa3,
title = "Natural history of HBeAg negative chronic hepatitis B virus infection: a cohort study",
abstract = "BACKGROUND/AIMS: The long-term virologic and biochemical changes in patients with HBeAg negative HBV infection, especially in Asia, remain unclear. To address this issue, we conducted a 3 year- retrospective, cohort study. METHODS: A total of 157 patients with HBeAg negative HBV infection who were monitored without treatment were reviewed between January 1999 and March 2004. Those patients were followed up every 3 months with liver function tests and serologic tests. All patients were stratified into 3 groups; inactive carrier (IC), viremic carrier (VC) and chronic hepatitis (CH). Serum HBV DNA was measured by a hybridization assay (sensitivity: 1.4 x 10(5)) genomes/mL, Digene Diagnostics, Silver Spring, USA). RESULTS: The median age of enrolled patients was 42.7 years (M:F=2.3:1). By single time-point observations, the 3 year-cohort prevalence of HBeAg negative CH varied from 12.7 to 35.8{\%} (median 20.7{\%}) HBeAg negative CH was accumulated over time (P=0.002) and transition rates among three groups after 3 years of follow-up are as follows: IC to CH, 6.0{\%}; IC to VC, 4.1{\%}; VC to CH, 23.2{\%}. VC seems to be a disease state in the middle of transition from IC to CH. CONCLUSIONS: We demonstrated the dynamic changing patterns of HBeAg negative CH with time, of which the change from IC or VC to CH was dominant.",
author = "Moon, {Chang Mo} and doyoung kim and Song, {Ki Jun} and Kim, {Ja Kyung} and Lee, {Hyun Woong} and Lee, {Jung Min} and Yoon, {Ki Tae} and Paik, {Yong Han} and Kim, {Dong Ki} and KwangHyub Han and Chon, {Chae Yoon} and Moon, {Young Myoung} and SangHoon Ahn",
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Moon, CM, kim, D, Song, KJ, Kim, JK, Lee, HW, Lee, JM, Yoon, KT, Paik, YH, Kim, DK, Han, K, Chon, CY, Moon, YM & Ahn, S 2006, 'Natural history of HBeAg negative chronic hepatitis B virus infection: a cohort study', The Korean journal of hepatology, vol. 12, no. 2, pp. 163-172.

Natural history of HBeAg negative chronic hepatitis B virus infection : a cohort study. / Moon, Chang Mo; kim, doyoung; Song, Ki Jun; Kim, Ja Kyung; Lee, Hyun Woong; Lee, Jung Min; Yoon, Ki Tae; Paik, Yong Han; Kim, Dong Ki; Han, KwangHyub; Chon, Chae Yoon; Moon, Young Myoung; Ahn, SangHoon.

In: The Korean journal of hepatology, Vol. 12, No. 2, 01.01.2006, p. 163-172.

Research output: Contribution to journalArticle

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T1 - Natural history of HBeAg negative chronic hepatitis B virus infection

T2 - a cohort study

AU - Moon, Chang Mo

AU - kim, doyoung

AU - Song, Ki Jun

AU - Kim, Ja Kyung

AU - Lee, Hyun Woong

AU - Lee, Jung Min

AU - Yoon, Ki Tae

AU - Paik, Yong Han

AU - Kim, Dong Ki

AU - Han, KwangHyub

AU - Chon, Chae Yoon

AU - Moon, Young Myoung

AU - Ahn, SangHoon

PY - 2006/1/1

Y1 - 2006/1/1

N2 - BACKGROUND/AIMS: The long-term virologic and biochemical changes in patients with HBeAg negative HBV infection, especially in Asia, remain unclear. To address this issue, we conducted a 3 year- retrospective, cohort study. METHODS: A total of 157 patients with HBeAg negative HBV infection who were monitored without treatment were reviewed between January 1999 and March 2004. Those patients were followed up every 3 months with liver function tests and serologic tests. All patients were stratified into 3 groups; inactive carrier (IC), viremic carrier (VC) and chronic hepatitis (CH). Serum HBV DNA was measured by a hybridization assay (sensitivity: 1.4 x 10(5)) genomes/mL, Digene Diagnostics, Silver Spring, USA). RESULTS: The median age of enrolled patients was 42.7 years (M:F=2.3:1). By single time-point observations, the 3 year-cohort prevalence of HBeAg negative CH varied from 12.7 to 35.8% (median 20.7%) HBeAg negative CH was accumulated over time (P=0.002) and transition rates among three groups after 3 years of follow-up are as follows: IC to CH, 6.0%; IC to VC, 4.1%; VC to CH, 23.2%. VC seems to be a disease state in the middle of transition from IC to CH. CONCLUSIONS: We demonstrated the dynamic changing patterns of HBeAg negative CH with time, of which the change from IC or VC to CH was dominant.

AB - BACKGROUND/AIMS: The long-term virologic and biochemical changes in patients with HBeAg negative HBV infection, especially in Asia, remain unclear. To address this issue, we conducted a 3 year- retrospective, cohort study. METHODS: A total of 157 patients with HBeAg negative HBV infection who were monitored without treatment were reviewed between January 1999 and March 2004. Those patients were followed up every 3 months with liver function tests and serologic tests. All patients were stratified into 3 groups; inactive carrier (IC), viremic carrier (VC) and chronic hepatitis (CH). Serum HBV DNA was measured by a hybridization assay (sensitivity: 1.4 x 10(5)) genomes/mL, Digene Diagnostics, Silver Spring, USA). RESULTS: The median age of enrolled patients was 42.7 years (M:F=2.3:1). By single time-point observations, the 3 year-cohort prevalence of HBeAg negative CH varied from 12.7 to 35.8% (median 20.7%) HBeAg negative CH was accumulated over time (P=0.002) and transition rates among three groups after 3 years of follow-up are as follows: IC to CH, 6.0%; IC to VC, 4.1%; VC to CH, 23.2%. VC seems to be a disease state in the middle of transition from IC to CH. CONCLUSIONS: We demonstrated the dynamic changing patterns of HBeAg negative CH with time, of which the change from IC or VC to CH was dominant.

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