Natural Variation in the Splice Site Strength of a Clock Gene and Species-Specific Thermal Adaptation

Kwang Huei Low, Cecilia Lim, Hyuk Wan Ko, Isaac Edery

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63 Citations (Scopus)

Abstract

We show that multiple suboptimal splice sites underlie the thermal-sensitive splicing of the period (per) 3′-terminal intron (dmpi8) from D. melanogaster, enabling this species to prolong its midday "siesta," a mechanism that likely diminishes the deleterious effects of heat during the longer summer days in temperate climates. In D. yakuba and D. santomea, which have a more ancestral distribution indigenous to Afro-equatorial regions wherein day length and temperature exhibit little fluctuation throughout the year, the splicing efficiencies of their per 3′-terminal introns do not exhibit thermal calibration, consistent with the little effect of temperature on the daily distribution of activity in these species. We propose that the weak splice sites on dmpi8 underlie a mechanism that facilitated the acclimation of the widely colonized D. melanogaster (and possibly D. simulans) to temperate climates and that natural selection operating at the level of splicing signals plays an important role in the thermal adaptation of life forms.

Original languageEnglish
Pages (from-to)1054-1067
Number of pages14
JournalNeuron
Volume60
Issue number6
DOIs
Publication statusPublished - 2008 Dec 26

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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