Near-infrared (NIR) fluorophores have unique features that endow them with several advantages over conventional shorter wavelength emitting dyes. As a result, they have been widely utilized as fluorescence and photoacoustic imaging agents, as well as photodynamic and photothermal therapeutic agents. However, non-targeting NIR fluorescence-emitting organic molecules have the drawback of low selectivity toward tumors, which potentially results in severe side effects caused by damage to normal tissues. Thus, the development of NIR fluorophore-based substances that target tumors is a highly active area in medicinal chemistry research. Research efforts carried out thus far have led to the development of a number of NIR fluorophore-based, tumor imaging and therapeutic agents. The discussion in this review focuses on the results of research reported in the 2012-2021 period, giving particular emphasis to studies of NIR small organic dye-based imaging and therapeutic agents that are designed utilizing cancer-selective strategies.
|Number of pages||52|
|Journal||Chemical Society reviews|
|Publication status||Published - 2022 Oct 13|
Bibliographical noteFunding Information:
This study was financially supported by the National Research Foundation of Korea (grant no. 2020R1A2C3003462 to I. S.) and the KRICT (grant no. SI-2231-30 and BSF22-914 to J. Y. H.).
© 2022 The Royal Society of Chemistry.
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