Necrosis of carcinoma cells using Co1-xNixFe 2O4 and Ba1-xSrxFe 12O19 ferrites under alternating magnetic field

Dong Hyun Kim, Kyoung Nam Kim, Kwang Mahn Kim, In Bo Shim, Yong Keun Lee

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4 Citations (Scopus)


The purpose of this study was to investigate the cell necrosis by the hysteric heating of Co1-xNixFe2O4 and Ba1-xSrxFe12O19 ferrites under external magnetic field with respect to applications in hyperthermic cancer treatments. Co1-xNixFe2O4 and Ba1-xSrxFe12O19 ferrites were synthesized by a sol-gel process. Variation of the temperature as a result of hysteresis heating was measured as a function of the exposure time to the external alternating magnetic field at frequencies of 0.1 - ~ 15 MHz. A human squamous cell carcinoma KB cell line was selected to determine the effect of the synthesized ferrites on the destruction of carcinoma cells in vitro using a methylthiazol tetrazolium bromide (MTT) method. When a CoFe2O 4 disc was placed in 0.2 ml of distilled water, the greatest temperature change (ΔT = 29.3°C) was observed. More than half of the malignant carcinoma cells were dead after being exposed to the 7-MHz ac magnetic field for 1 h by CoFe2O4 ferrites, while normal cells survived more than 60% of the time.

Original languageEnglish
Pages (from-to)2985-2987
Number of pages3
JournalIEEE Transactions on Magnetics
Issue number4 II
Publication statusPublished - 2004 Jul

Bibliographical note

Funding Information:
Manuscript received October 16, 2003. This work was supported by Grant R01-2001-000-00157 from the Basic Research Program of the Korea Science and Engineering Foundation.

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering


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