Necrosis of carcinoma cells using Co1-xNixFe 2O4 and Ba1-xSrxFe 12O19 ferrites under alternating magnetic field

Dong Hyun Kim, Kyoung Nam Kim, Kwangmahn Kim, In Bo Shim, Yong Keun Lee

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The purpose of this study was to investigate the cell necrosis by the hysteric heating of Co1-xNixFe2O4 and Ba1-xSrxFe12O19 ferrites under external magnetic field with respect to applications in hyperthermic cancer treatments. Co1-xNixFe2O4 and Ba1-xSrxFe12O19 ferrites were synthesized by a sol-gel process. Variation of the temperature as a result of hysteresis heating was measured as a function of the exposure time to the external alternating magnetic field at frequencies of 0.1 - ~ 15 MHz. A human squamous cell carcinoma KB cell line was selected to determine the effect of the synthesized ferrites on the destruction of carcinoma cells in vitro using a methylthiazol tetrazolium bromide (MTT) method. When a CoFe2O 4 disc was placed in 0.2 ml of distilled water, the greatest temperature change (ΔT = 29.3°C) was observed. More than half of the malignant carcinoma cells were dead after being exposed to the 7-MHz ac magnetic field for 1 h by CoFe2O4 ferrites, while normal cells survived more than 60% of the time.

Original languageEnglish
Pages (from-to)2985-2987
Number of pages3
JournalIEEE Transactions on Magnetics
Volume40
Issue number4 II
DOIs
Publication statusPublished - 2004 Jul 1

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Ferrites
Cells
Magnetic fields
Heating
Oncology
Bromides
Sol-gel process
Hysteresis
Temperature
Water

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

Cite this

Kim, Dong Hyun ; Kim, Kyoung Nam ; Kim, Kwangmahn ; Shim, In Bo ; Lee, Yong Keun. / Necrosis of carcinoma cells using Co1-xNixFe 2O4 and Ba1-xSrxFe 12O19 ferrites under alternating magnetic field. In: IEEE Transactions on Magnetics. 2004 ; Vol. 40, No. 4 II. pp. 2985-2987.
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Necrosis of carcinoma cells using Co1-xNixFe 2O4 and Ba1-xSrxFe 12O19 ferrites under alternating magnetic field. / Kim, Dong Hyun; Kim, Kyoung Nam; Kim, Kwangmahn; Shim, In Bo; Lee, Yong Keun.

In: IEEE Transactions on Magnetics, Vol. 40, No. 4 II, 01.07.2004, p. 2985-2987.

Research output: Contribution to journalArticle

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