Neoadjuvant chemotherapy and radiation for inoperable carcinoma of the maxillary antrum: A matched-control study

Gwi Eon Kim, Sei Kyung Chang, Sang Wook Lee, Hong Ryull Pyo, Eun Chang Choi, Jae Kyung Roh, Ki Chang Keum, Chang Geol Lee, Chang Ok Suh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A matched-control study comparing standard radiotherapy versus neoadjuvant chemotherapy and radiation was undertaken to clarify the effects of neoadjuvant systemic chemotherapy for locally advanced squamous cell carcinoma of the maxillary antrum. Thirty-four patients with inoperable maxillary cancer were treated with neoadjuvant chemotherapy and radiotherapy (Group II). Before starting radiotherapy, all patients in Group II received two or three cycles of neoadjuvant chemotherapy consisting of cisplatin and a 5-day continuous infusion of 5-fluorouracil with or without intravenous injection of vinblastine. Radiation doses ranged from 66 Gy to 75 Gy (median, 70 Gy). The response rate, patterns of failure, toxicity, and survival for Group II were compared with those for 34 stage-matched patients treated with radiation alone (Group I). Despite a higher response rate to neoadjuvant chemotherapy, the recurrence rate and patterns of treatment failure were not influenced by the addition of neoadjuvant chemotherapy. In most cases, neoadjuvant chemotherapy did not interfere with subsequent radiotherapy, and radiation-induced late complications occurred equally in both treatment groups. After a median follow-up of 48 months, there was no significant difference in 5-year actuarial survival or disease-free survival between the two treatment groups. Radiation alone for inoperable maxillary cancer was clearly suboptimal for improving local control and survival rate, but neoadjuvant chemotherapy in addition to standard radiotherapy failed to demonstrate any therapeutic advantage over radiation alone.

Original languageEnglish
Pages (from-to)301-308
Number of pages8
JournalAmerican Journal of Clinical Oncology: Cancer Clinical Trials
Volume23
Issue number3
DOIs
Publication statusPublished - 2000 Dec 1

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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