Abstract
Aim: The aim of this study was to develop a novel artificial nerve conduit and to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rabbits. Material and methods: The nerve conduit was made of a poly (L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel. The conduits were implanted into a 15 mm gap in the peroneal nerves of five rabbits. On the contralateral side, the defects were bridged with collagen-filled vein grafts. Results: Twelve weeks postoperatively nerve regeneration was superior to the vein graft in the PLGA-coated collagen tube, both morphologically and electrophysiologically. Conclusion: The results indicate the superiority of the PLGA-coated collagen tube over vein grafts. Furthermore, they show that entubulation repair with this type of tube can support nerve regeneration over a nerve gap distance of at least 15 mm.
| Original language | English |
|---|---|
| Pages (from-to) | 50-56 |
| Number of pages | 7 |
| Journal | Journal of Cranio-Maxillofacial Surgery |
| Volume | 34 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2006 Jan 1 |
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All Science Journal Classification (ASJC) codes
- Surgery
- Oral Surgery
- Otorhinolaryngology
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Nerve regeneration with the use of a poly(L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel. / Lee, Doug Youn; Choi, Byung Ho; Park, Ji Ho; Zhu, Shi Jiang; Kim, Byung Yong; Huh, Jin Young; Lee, Seoung Ho; Jung, Jae Hyung; Kim, Sung Hoon.
In: Journal of Cranio-Maxillofacial Surgery, Vol. 34, No. 1, 01.01.2006, p. 50-56.Research output: Contribution to journal › Article
TY - JOUR
T1 - Nerve regeneration with the use of a poly(L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel
AU - Lee, Doug Youn
AU - Choi, Byung Ho
AU - Park, Ji Ho
AU - Zhu, Shi Jiang
AU - Kim, Byung Yong
AU - Huh, Jin Young
AU - Lee, Seoung Ho
AU - Jung, Jae Hyung
AU - Kim, Sung Hoon
PY - 2006/1/1
Y1 - 2006/1/1
N2 - Aim: The aim of this study was to develop a novel artificial nerve conduit and to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rabbits. Material and methods: The nerve conduit was made of a poly (L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel. The conduits were implanted into a 15 mm gap in the peroneal nerves of five rabbits. On the contralateral side, the defects were bridged with collagen-filled vein grafts. Results: Twelve weeks postoperatively nerve regeneration was superior to the vein graft in the PLGA-coated collagen tube, both morphologically and electrophysiologically. Conclusion: The results indicate the superiority of the PLGA-coated collagen tube over vein grafts. Furthermore, they show that entubulation repair with this type of tube can support nerve regeneration over a nerve gap distance of at least 15 mm.
AB - Aim: The aim of this study was to develop a novel artificial nerve conduit and to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rabbits. Material and methods: The nerve conduit was made of a poly (L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel. The conduits were implanted into a 15 mm gap in the peroneal nerves of five rabbits. On the contralateral side, the defects were bridged with collagen-filled vein grafts. Results: Twelve weeks postoperatively nerve regeneration was superior to the vein graft in the PLGA-coated collagen tube, both morphologically and electrophysiologically. Conclusion: The results indicate the superiority of the PLGA-coated collagen tube over vein grafts. Furthermore, they show that entubulation repair with this type of tube can support nerve regeneration over a nerve gap distance of at least 15 mm.
UR - http://www.scopus.com/inward/record.url?scp=30944455453&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=30944455453&partnerID=8YFLogxK
U2 - 10.1016/j.jcms.2005.07.011
DO - 10.1016/j.jcms.2005.07.011
M3 - Article
C2 - 16343912
AN - SCOPUS:30944455453
VL - 34
SP - 50
EP - 56
JO - Journal of Cranio-Maxillo-Facial Surgery
JF - Journal of Cranio-Maxillo-Facial Surgery
SN - 1010-5182
IS - 1
ER -