Nerve regeneration with the use of a poly(L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel

Doug Youn Lee, Byung Ho Choi, Ji Ho Park, Shi Jiang Zhu, Byung Yong Kim, Jin Young Huh, Seoung Ho Lee, Jae Hyung Jung, Sung Hoon Kim

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

Aim: The aim of this study was to develop a novel artificial nerve conduit and to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rabbits. Material and methods: The nerve conduit was made of a poly (L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel. The conduits were implanted into a 15 mm gap in the peroneal nerves of five rabbits. On the contralateral side, the defects were bridged with collagen-filled vein grafts. Results: Twelve weeks postoperatively nerve regeneration was superior to the vein graft in the PLGA-coated collagen tube, both morphologically and electrophysiologically. Conclusion: The results indicate the superiority of the PLGA-coated collagen tube over vein grafts. Furthermore, they show that entubulation repair with this type of tube can support nerve regeneration over a nerve gap distance of at least 15 mm.

Original languageEnglish
Pages (from-to)50-56
Number of pages7
JournalJournal of Cranio-Maxillofacial Surgery
Volume34
Issue number1
DOIs
Publication statusPublished - 2006 Jan 1

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oral Surgery
  • Otorhinolaryngology

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