Nerve regeneration with the use of a poly(L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel

Doug Youn Lee; Byung Ho Choi; Ji Ho Park; Shi Jiang Zhu; Byung Yong Kim; Jin Young Huh; Seoung Ho Lee; Jae Hyung Jung; Sung Hoon Kim

doi:10.1016/j.jcms.2005.07.011

Nerve regeneration with the use of a poly(L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel

Doug Youn Lee, Byung Ho Choi, Ji Ho Park, Shi Jiang Zhu, Byung Yong Kim, Jin Young Huh, Seoung Ho Lee, Jae Hyung Jung, Sung Hoon Kim

Dentistry

Research output: Contribution to journal › Article › peer-review

47 Citations (Scopus)

Abstract

Aim: The aim of this study was to develop a novel artificial nerve conduit and to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rabbits. Material and methods: The nerve conduit was made of a poly (L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel. The conduits were implanted into a 15 mm gap in the peroneal nerves of five rabbits. On the contralateral side, the defects were bridged with collagen-filled vein grafts. Results: Twelve weeks postoperatively nerve regeneration was superior to the vein graft in the PLGA-coated collagen tube, both morphologically and electrophysiologically. Conclusion: The results indicate the superiority of the PLGA-coated collagen tube over vein grafts. Furthermore, they show that entubulation repair with this type of tube can support nerve regeneration over a nerve gap distance of at least 15 mm.

Original language	English
Pages (from-to)	50-56
Number of pages	7
Journal	Journal of Cranio-Maxillofacial Surgery
Volume	34
Issue number	1
DOIs	https://doi.org/10.1016/j.jcms.2005.07.011
Publication status	Published - 2006 Jan

Bibliographical note

Funding Information:
This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea to Choi, Byung-Ho (02-PJ1-PG1-CH07-0001).

All Science Journal Classification (ASJC) codes

Surgery
Oral Surgery
Otorhinolaryngology

Access to Document

10.1016/j.jcms.2005.07.011

Fingerprint Dive into the research topics of 'Nerve regeneration with the use of a poly(L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel'. Together they form a unique fingerprint.

Cite this

@article{0365eb180c6f4d8ab7ba341bee4d2b60,

title = "Nerve regeneration with the use of a poly(L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel",

abstract = "Aim: The aim of this study was to develop a novel artificial nerve conduit and to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rabbits. Material and methods: The nerve conduit was made of a poly (L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel. The conduits were implanted into a 15 mm gap in the peroneal nerves of five rabbits. On the contralateral side, the defects were bridged with collagen-filled vein grafts. Results: Twelve weeks postoperatively nerve regeneration was superior to the vein graft in the PLGA-coated collagen tube, both morphologically and electrophysiologically. Conclusion: The results indicate the superiority of the PLGA-coated collagen tube over vein grafts. Furthermore, they show that entubulation repair with this type of tube can support nerve regeneration over a nerve gap distance of at least 15 mm.",

author = "Lee, {Doug Youn} and Choi, {Byung Ho} and Park, {Ji Ho} and Zhu, {Shi Jiang} and Kim, {Byung Yong} and Huh, {Jin Young} and Lee, {Seoung Ho} and Jung, {Jae Hyung} and Kim, {Sung Hoon}",

note = "Funding Information: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea to Choi, Byung-Ho (02-PJ1-PG1-CH07-0001).",

year = "2006",

month = jan,

doi = "10.1016/j.jcms.2005.07.011",

language = "English",

volume = "34",

pages = "50--56",

journal = "Journal of Cranio-Maxillo-Facial Surgery",

issn = "1010-5182",

publisher = "Churchill Livingstone",

number = "1",

}

Nerve regeneration with the use of a poly(L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel. / Lee, Doug Youn; Choi, Byung Ho; Park, Ji Ho; Zhu, Shi Jiang; Kim, Byung Yong; Huh, Jin Young; Lee, Seoung Ho; Jung, Jae Hyung; Kim, Sung Hoon.

In: Journal of Cranio-Maxillofacial Surgery, Vol. 34, No. 1, 01.2006, p. 50-56.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Nerve regeneration with the use of a poly(L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel

AU - Lee, Doug Youn

AU - Choi, Byung Ho

AU - Park, Ji Ho

AU - Zhu, Shi Jiang

AU - Kim, Byung Yong

AU - Huh, Jin Young

AU - Lee, Seoung Ho

AU - Jung, Jae Hyung

AU - Kim, Sung Hoon

N1 - Funding Information: This study was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea to Choi, Byung-Ho (02-PJ1-PG1-CH07-0001).

PY - 2006/1

Y1 - 2006/1

N2 - Aim: The aim of this study was to develop a novel artificial nerve conduit and to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rabbits. Material and methods: The nerve conduit was made of a poly (L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel. The conduits were implanted into a 15 mm gap in the peroneal nerves of five rabbits. On the contralateral side, the defects were bridged with collagen-filled vein grafts. Results: Twelve weeks postoperatively nerve regeneration was superior to the vein graft in the PLGA-coated collagen tube, both morphologically and electrophysiologically. Conclusion: The results indicate the superiority of the PLGA-coated collagen tube over vein grafts. Furthermore, they show that entubulation repair with this type of tube can support nerve regeneration over a nerve gap distance of at least 15 mm.

AB - Aim: The aim of this study was to develop a novel artificial nerve conduit and to evaluate its efficiency based on the promotion of peripheral nerve regeneration in rabbits. Material and methods: The nerve conduit was made of a poly (L-lactide-co-glycolic acid)-coated collagen tube filled with collagen gel. The conduits were implanted into a 15 mm gap in the peroneal nerves of five rabbits. On the contralateral side, the defects were bridged with collagen-filled vein grafts. Results: Twelve weeks postoperatively nerve regeneration was superior to the vein graft in the PLGA-coated collagen tube, both morphologically and electrophysiologically. Conclusion: The results indicate the superiority of the PLGA-coated collagen tube over vein grafts. Furthermore, they show that entubulation repair with this type of tube can support nerve regeneration over a nerve gap distance of at least 15 mm.

UR - http://www.scopus.com/inward/record.url?scp=30944455453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=30944455453&partnerID=8YFLogxK

U2 - 10.1016/j.jcms.2005.07.011

DO - 10.1016/j.jcms.2005.07.011

M3 - Article

C2 - 16343912

AN - SCOPUS:30944455453

VL - 34

SP - 50

EP - 56

JO - Journal of Cranio-Maxillo-Facial Surgery

JF - Journal of Cranio-Maxillo-Facial Surgery

SN - 1010-5182

IS - 1

ER -