Abstract
Self-referential processing, theory of mind, and working memory are distorted in social anxiety disorder (SAD). This study aimed to investigate characteristics of altered self-referential working memory processing and resting-state functional connectivity in patients with SAD. Twenty patients and 20 healthy controls underwent functional magnetic resonance imaging at resting-state and while performing a working memory task containing faces with self-referential positive or negative comments and three memory phases (encoding, maintenance, and retrieval). Task-related results were compared between groups and tested for correlations. Resting-state connectivity between amygdala subregions and regions showing a task-related difference was also compared between groups. Patients compared to controls showed augmented memory for the negative comments, hyperactivation of the dorsomedial prefrontal cortex and temporo-parietal junction during encoding, and hypoactivation of the dorsolateral prefrontal cortex and insula during retrieval. At resting-state, increased connectivity of amygdala subregions with multiple task-related regions was found in patients. These findings suggest that the encoding process in SAD is accompanied by altered involvement of self-referential processing and theory of mind, whereas the retrieval process reflects impaired cognitive control. These memory-related processing may be affected by predisposing resting-state hyperconnectivity with the amygdala, and may underlie a hypersensitivity to negative comments and post-event reflection in SAD.
| Original language | English |
|---|---|
| Pages (from-to) | 139-147 |
| Number of pages | 9 |
| Journal | Neuroscience Letters |
| Volume | 627 |
| DOIs | |
| Publication status | Published - 2016 Aug 3 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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Neural activity during self-referential working memory and the underlying role of the amygdala in social anxiety disorder. / Yoon, Hyung Jun; Kim, Jin Seong; Shin, Yu Bin; Choi, Soo Hee; Lee, Seung Koo; Kim, Jae Jin.
In: Neuroscience Letters, Vol. 627, 03.08.2016, p. 139-147.Research output: Contribution to journal › Article
TY - JOUR
T1 - Neural activity during self-referential working memory and the underlying role of the amygdala in social anxiety disorder
AU - Yoon, Hyung Jun
AU - Kim, Jin Seong
AU - Shin, Yu Bin
AU - Choi, Soo Hee
AU - Lee, Seung Koo
AU - Kim, Jae Jin
PY - 2016/8/3
Y1 - 2016/8/3
N2 - Self-referential processing, theory of mind, and working memory are distorted in social anxiety disorder (SAD). This study aimed to investigate characteristics of altered self-referential working memory processing and resting-state functional connectivity in patients with SAD. Twenty patients and 20 healthy controls underwent functional magnetic resonance imaging at resting-state and while performing a working memory task containing faces with self-referential positive or negative comments and three memory phases (encoding, maintenance, and retrieval). Task-related results were compared between groups and tested for correlations. Resting-state connectivity between amygdala subregions and regions showing a task-related difference was also compared between groups. Patients compared to controls showed augmented memory for the negative comments, hyperactivation of the dorsomedial prefrontal cortex and temporo-parietal junction during encoding, and hypoactivation of the dorsolateral prefrontal cortex and insula during retrieval. At resting-state, increased connectivity of amygdala subregions with multiple task-related regions was found in patients. These findings suggest that the encoding process in SAD is accompanied by altered involvement of self-referential processing and theory of mind, whereas the retrieval process reflects impaired cognitive control. These memory-related processing may be affected by predisposing resting-state hyperconnectivity with the amygdala, and may underlie a hypersensitivity to negative comments and post-event reflection in SAD.
AB - Self-referential processing, theory of mind, and working memory are distorted in social anxiety disorder (SAD). This study aimed to investigate characteristics of altered self-referential working memory processing and resting-state functional connectivity in patients with SAD. Twenty patients and 20 healthy controls underwent functional magnetic resonance imaging at resting-state and while performing a working memory task containing faces with self-referential positive or negative comments and three memory phases (encoding, maintenance, and retrieval). Task-related results were compared between groups and tested for correlations. Resting-state connectivity between amygdala subregions and regions showing a task-related difference was also compared between groups. Patients compared to controls showed augmented memory for the negative comments, hyperactivation of the dorsomedial prefrontal cortex and temporo-parietal junction during encoding, and hypoactivation of the dorsolateral prefrontal cortex and insula during retrieval. At resting-state, increased connectivity of amygdala subregions with multiple task-related regions was found in patients. These findings suggest that the encoding process in SAD is accompanied by altered involvement of self-referential processing and theory of mind, whereas the retrieval process reflects impaired cognitive control. These memory-related processing may be affected by predisposing resting-state hyperconnectivity with the amygdala, and may underlie a hypersensitivity to negative comments and post-event reflection in SAD.
UR - http://www.scopus.com/inward/record.url?scp=84973647178&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84973647178&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2016.05.068
DO - 10.1016/j.neulet.2016.05.068
M3 - Article
C2 - 27260987
AN - SCOPUS:84973647178
VL - 627
SP - 139
EP - 147
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
ER -