Neural basis of anhedonia as a failure to predict pleasantness in schizophrenia

Soo Hee Choi, Hyeongrae Lee, Jeonghun Ku, Kang Joon Yoon, Jae-Jin Kim

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objectives. Anhedonia in schizophrenia results from a deficit in anticipatory pleasure rather than consummatory pleasure. This study aimed to determine the neural basis of the predictive and experiential components of anticipatory pleasure in schizophrenia. Methods. A hedonic rating task was performed by 15 patients with schizophrenia and 17 controls while undergoing functional magnetic resonance imaging. Participants evaluated the level of pleasantness for the preview/predictive phase, comprising a narration and adjunctive audiovisual stimuli for pleasurable experience, and the subsequent viewing/experiential phase, comprising a video clip for a pleasant event. Results. A significant group-by-phase interaction was seen in the rostral anterior cingulate cortex (ACC) and caudate, resulting from reduced activations in patients during the preview phase. Patients showed significantly reduced activation in the frontopolar cortex and rostral ACC during the preview phase. The signal changes in the caudate and frontopolar cortex were associated with increase in hedonic response during the sequential pleasure experiences. Conclusions. Augmentation of hedonic enjoyment between the predictive and experiential stages of anticipatory pleasure is reduced in schizophrenia because of diminished activity in the reward-related regions during the prediction of pleasure. During cued-emotional experiences of anticipatory pleasure, patients seem to have difficulties in the integration of emotional information.

Original languageEnglish
Pages (from-to)525-533
Number of pages9
JournalWorld Journal of Biological Psychiatry
Volume15
Issue number7
DOIs
Publication statusPublished - 2014 Sep 1

Fingerprint

Anhedonia
Pleasure
Schizophrenia
Gyrus Cinguli
Narration
Reward
Surgical Instruments
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Choi, Soo Hee ; Lee, Hyeongrae ; Ku, Jeonghun ; Yoon, Kang Joon ; Kim, Jae-Jin. / Neural basis of anhedonia as a failure to predict pleasantness in schizophrenia. In: World Journal of Biological Psychiatry. 2014 ; Vol. 15, No. 7. pp. 525-533.
@article{2101d106b1774e53bf151c86a91b842d,
title = "Neural basis of anhedonia as a failure to predict pleasantness in schizophrenia",
abstract = "Objectives. Anhedonia in schizophrenia results from a deficit in anticipatory pleasure rather than consummatory pleasure. This study aimed to determine the neural basis of the predictive and experiential components of anticipatory pleasure in schizophrenia. Methods. A hedonic rating task was performed by 15 patients with schizophrenia and 17 controls while undergoing functional magnetic resonance imaging. Participants evaluated the level of pleasantness for the preview/predictive phase, comprising a narration and adjunctive audiovisual stimuli for pleasurable experience, and the subsequent viewing/experiential phase, comprising a video clip for a pleasant event. Results. A significant group-by-phase interaction was seen in the rostral anterior cingulate cortex (ACC) and caudate, resulting from reduced activations in patients during the preview phase. Patients showed significantly reduced activation in the frontopolar cortex and rostral ACC during the preview phase. The signal changes in the caudate and frontopolar cortex were associated with increase in hedonic response during the sequential pleasure experiences. Conclusions. Augmentation of hedonic enjoyment between the predictive and experiential stages of anticipatory pleasure is reduced in schizophrenia because of diminished activity in the reward-related regions during the prediction of pleasure. During cued-emotional experiences of anticipatory pleasure, patients seem to have difficulties in the integration of emotional information.",
author = "Choi, {Soo Hee} and Hyeongrae Lee and Jeonghun Ku and Yoon, {Kang Joon} and Jae-Jin Kim",
year = "2014",
month = "9",
day = "1",
doi = "10.3109/15622975.2013.819121",
language = "English",
volume = "15",
pages = "525--533",
journal = "World Journal of Biological Psychiatry",
issn = "1562-2975",
publisher = "Informa Healthcare",
number = "7",

}

Neural basis of anhedonia as a failure to predict pleasantness in schizophrenia. / Choi, Soo Hee; Lee, Hyeongrae; Ku, Jeonghun; Yoon, Kang Joon; Kim, Jae-Jin.

In: World Journal of Biological Psychiatry, Vol. 15, No. 7, 01.09.2014, p. 525-533.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neural basis of anhedonia as a failure to predict pleasantness in schizophrenia

AU - Choi, Soo Hee

AU - Lee, Hyeongrae

AU - Ku, Jeonghun

AU - Yoon, Kang Joon

AU - Kim, Jae-Jin

PY - 2014/9/1

Y1 - 2014/9/1

N2 - Objectives. Anhedonia in schizophrenia results from a deficit in anticipatory pleasure rather than consummatory pleasure. This study aimed to determine the neural basis of the predictive and experiential components of anticipatory pleasure in schizophrenia. Methods. A hedonic rating task was performed by 15 patients with schizophrenia and 17 controls while undergoing functional magnetic resonance imaging. Participants evaluated the level of pleasantness for the preview/predictive phase, comprising a narration and adjunctive audiovisual stimuli for pleasurable experience, and the subsequent viewing/experiential phase, comprising a video clip for a pleasant event. Results. A significant group-by-phase interaction was seen in the rostral anterior cingulate cortex (ACC) and caudate, resulting from reduced activations in patients during the preview phase. Patients showed significantly reduced activation in the frontopolar cortex and rostral ACC during the preview phase. The signal changes in the caudate and frontopolar cortex were associated with increase in hedonic response during the sequential pleasure experiences. Conclusions. Augmentation of hedonic enjoyment between the predictive and experiential stages of anticipatory pleasure is reduced in schizophrenia because of diminished activity in the reward-related regions during the prediction of pleasure. During cued-emotional experiences of anticipatory pleasure, patients seem to have difficulties in the integration of emotional information.

AB - Objectives. Anhedonia in schizophrenia results from a deficit in anticipatory pleasure rather than consummatory pleasure. This study aimed to determine the neural basis of the predictive and experiential components of anticipatory pleasure in schizophrenia. Methods. A hedonic rating task was performed by 15 patients with schizophrenia and 17 controls while undergoing functional magnetic resonance imaging. Participants evaluated the level of pleasantness for the preview/predictive phase, comprising a narration and adjunctive audiovisual stimuli for pleasurable experience, and the subsequent viewing/experiential phase, comprising a video clip for a pleasant event. Results. A significant group-by-phase interaction was seen in the rostral anterior cingulate cortex (ACC) and caudate, resulting from reduced activations in patients during the preview phase. Patients showed significantly reduced activation in the frontopolar cortex and rostral ACC during the preview phase. The signal changes in the caudate and frontopolar cortex were associated with increase in hedonic response during the sequential pleasure experiences. Conclusions. Augmentation of hedonic enjoyment between the predictive and experiential stages of anticipatory pleasure is reduced in schizophrenia because of diminished activity in the reward-related regions during the prediction of pleasure. During cued-emotional experiences of anticipatory pleasure, patients seem to have difficulties in the integration of emotional information.

UR - http://www.scopus.com/inward/record.url?scp=84907259093&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84907259093&partnerID=8YFLogxK

U2 - 10.3109/15622975.2013.819121

DO - 10.3109/15622975.2013.819121

M3 - Article

VL - 15

SP - 525

EP - 533

JO - World Journal of Biological Psychiatry

JF - World Journal of Biological Psychiatry

SN - 1562-2975

IS - 7

ER -