Abstract
Although results from neuropsychological and neuroimaging studies have postulated the involvement of the frontal lobe and the subcortical brain regions in the pathophysiology of obsessive-compulsive disorder (OCD), neuroimaging studies have provided little evidence that cognitive abnormalities in patients with OCD are related to dysfunctions in these areas. This study was designed to determine whether the clinical features and cognitive deficits of OCD might be taken to reflect frontal-subcortical dysfunction. Fourteen patients with OCD and 14 case-matched normal subjects completed clinical and cognitive evaluation, including four sets of neuropsychological tests that assessed the executive functions and visual memory. Cerebral glucose metabolic rates were measured by using positron emission tomography (PET) with 18F-fluorodeoxyglucose. Behavioral and PET data were analyzed using statistical parametric mapping for group differences and behavioral-metabolic correlates. The right orbitofrontal cortex showed increased metabolic activity and the left parieto-occipital junction showed decreased metabolic activity in patients. Metabolism in the right hippocampus, the left putamen and the right parietal region was associated with the severity of obsessive-compulsive symptoms. Correlations between metabolic rates and neuropsychological test scores in the prefrontal cortex and the putamen occurred only in the patient group. These results suggest that patients with OCD have distinct features of brain metabolic activities for performing cognitive tasks as well as presenting obsessive-compulsive symptoms. In particular, the frontal-subcortical circuits might mediate not only symptomatic expression but also cognitive expression in patients with OCD.
| Original language | English |
|---|---|
| Pages (from-to) | 37-47 |
| Number of pages | 11 |
| Journal | Psychiatry Research - Neuroimaging |
| Volume | 122 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2003 Jan 20 |
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All Science Journal Classification (ASJC) codes
- Neuroscience (miscellaneous)
- Radiology Nuclear Medicine and imaging
- Psychiatry and Mental health
Cite this
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Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive-compulsive disorder. / Kwon, Jun Soo; Kim, Jae Jin; Lee, Dong Woo; Lee, Jae Sung; Lee, Dong Soo; Kim, Myung Sun; Lyoo, In Kyoon; Cho, Maeng Je; Lee, Myung Chul.
In: Psychiatry Research - Neuroimaging, Vol. 122, No. 1, 20.01.2003, p. 37-47.Research output: Contribution to journal › Article
TY - JOUR
T1 - Neural correlates of clinical symptoms and cognitive dysfunctions in obsessive-compulsive disorder
AU - Kwon, Jun Soo
AU - Kim, Jae Jin
AU - Lee, Dong Woo
AU - Lee, Jae Sung
AU - Lee, Dong Soo
AU - Kim, Myung Sun
AU - Lyoo, In Kyoon
AU - Cho, Maeng Je
AU - Lee, Myung Chul
PY - 2003/1/20
Y1 - 2003/1/20
N2 - Although results from neuropsychological and neuroimaging studies have postulated the involvement of the frontal lobe and the subcortical brain regions in the pathophysiology of obsessive-compulsive disorder (OCD), neuroimaging studies have provided little evidence that cognitive abnormalities in patients with OCD are related to dysfunctions in these areas. This study was designed to determine whether the clinical features and cognitive deficits of OCD might be taken to reflect frontal-subcortical dysfunction. Fourteen patients with OCD and 14 case-matched normal subjects completed clinical and cognitive evaluation, including four sets of neuropsychological tests that assessed the executive functions and visual memory. Cerebral glucose metabolic rates were measured by using positron emission tomography (PET) with 18F-fluorodeoxyglucose. Behavioral and PET data were analyzed using statistical parametric mapping for group differences and behavioral-metabolic correlates. The right orbitofrontal cortex showed increased metabolic activity and the left parieto-occipital junction showed decreased metabolic activity in patients. Metabolism in the right hippocampus, the left putamen and the right parietal region was associated with the severity of obsessive-compulsive symptoms. Correlations between metabolic rates and neuropsychological test scores in the prefrontal cortex and the putamen occurred only in the patient group. These results suggest that patients with OCD have distinct features of brain metabolic activities for performing cognitive tasks as well as presenting obsessive-compulsive symptoms. In particular, the frontal-subcortical circuits might mediate not only symptomatic expression but also cognitive expression in patients with OCD.
AB - Although results from neuropsychological and neuroimaging studies have postulated the involvement of the frontal lobe and the subcortical brain regions in the pathophysiology of obsessive-compulsive disorder (OCD), neuroimaging studies have provided little evidence that cognitive abnormalities in patients with OCD are related to dysfunctions in these areas. This study was designed to determine whether the clinical features and cognitive deficits of OCD might be taken to reflect frontal-subcortical dysfunction. Fourteen patients with OCD and 14 case-matched normal subjects completed clinical and cognitive evaluation, including four sets of neuropsychological tests that assessed the executive functions and visual memory. Cerebral glucose metabolic rates were measured by using positron emission tomography (PET) with 18F-fluorodeoxyglucose. Behavioral and PET data were analyzed using statistical parametric mapping for group differences and behavioral-metabolic correlates. The right orbitofrontal cortex showed increased metabolic activity and the left parieto-occipital junction showed decreased metabolic activity in patients. Metabolism in the right hippocampus, the left putamen and the right parietal region was associated with the severity of obsessive-compulsive symptoms. Correlations between metabolic rates and neuropsychological test scores in the prefrontal cortex and the putamen occurred only in the patient group. These results suggest that patients with OCD have distinct features of brain metabolic activities for performing cognitive tasks as well as presenting obsessive-compulsive symptoms. In particular, the frontal-subcortical circuits might mediate not only symptomatic expression but also cognitive expression in patients with OCD.
UR - http://www.scopus.com/inward/record.url?scp=0037455301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037455301&partnerID=8YFLogxK
U2 - 10.1016/S0925-4927(02)00104-X
DO - 10.1016/S0925-4927(02)00104-X
M3 - Article
C2 - 12589881
AN - SCOPUS:0037455301
VL - 122
SP - 37
EP - 47
JO - Psychiatry Research - Neuroimaging
JF - Psychiatry Research - Neuroimaging
SN - 0925-4927
IS - 1
ER -