Neural correlates of progressive reduction of bradykinesia in de novo Parkinson's disease

Eeksung Lee, Ji Eun Lee, Kwangsun Yoo, Jin Yong Hong, Jungsu Oh, Mun Kyung Sunwoo, Jae Seung Kim, Yong Jeong, Phil Hyu Lee, Young Ho Sohn, Suk Yun Kang

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A progressive reduction in the speed and amplitude of repetitive action is an essential component of bradykinesia, which is called sequence effect (SE). Because SE is specific to Parkinson's disease (PD) and is suggested to be associated with motor arrest, its features are of great interest. The aim of this study was, for the first time, to find the neural correlates of SE and to demonstrate whether dopaminergic deficit is correlated with SE. Methods: We enrolled 12 patients with de novo PD at a tertiary referral hospital. Correlations between SE severity and alterations in gray and white matter were studied. The association between severity of the SE and striatal dopaminergic deficits was also analyzed. Results: There was a significant negative correlation between the volumetric changes in the anterior cingulate cortex (ACC) and the inferior semilunar lobule of the cerebellum and the degree of SE. There was a significant correlation between the long association fibers (the superior longitudinal fasciculus, the uncinate fasciculus, and the inferior fronto-occipital fasciculus) connecting the frontal lobes to the temporal, parietal, and occipital lobes and SE. There was a significant negative correlation between SE in the more affected hand and the caudate dopamine transporter binding in the more affected hemisphere. Conclusions: Our results suggest that the ACC and the cerebellum (inferior semilunar lobule) are associated with the severity of SE. Taken together with DTI findings, the present study proposes that ACC may have an important role. Our data show that the caudate dopaminergic activity may be related to SE.

Original languageEnglish
Pages (from-to)1376-1381
Number of pages6
JournalParkinsonism and Related Disorders
Volume20
Issue number12
DOIs
Publication statusPublished - 2014 Dec 1

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Hypokinesia
Gyrus Cinguli
Parkinson Disease
Cerebellum
Corpus Striatum
Occipital Lobe
Parietal Lobe
Dopamine Plasma Membrane Transport Proteins
Frontal Lobe
Temporal Lobe
Tertiary Care Centers
Hand

All Science Journal Classification (ASJC) codes

  • Neurology
  • Geriatrics and Gerontology
  • Clinical Neurology

Cite this

Lee, Eeksung ; Lee, Ji Eun ; Yoo, Kwangsun ; Hong, Jin Yong ; Oh, Jungsu ; Sunwoo, Mun Kyung ; Kim, Jae Seung ; Jeong, Yong ; Lee, Phil Hyu ; Sohn, Young Ho ; Kang, Suk Yun. / Neural correlates of progressive reduction of bradykinesia in de novo Parkinson's disease. In: Parkinsonism and Related Disorders. 2014 ; Vol. 20, No. 12. pp. 1376-1381.
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abstract = "A progressive reduction in the speed and amplitude of repetitive action is an essential component of bradykinesia, which is called sequence effect (SE). Because SE is specific to Parkinson's disease (PD) and is suggested to be associated with motor arrest, its features are of great interest. The aim of this study was, for the first time, to find the neural correlates of SE and to demonstrate whether dopaminergic deficit is correlated with SE. Methods: We enrolled 12 patients with de novo PD at a tertiary referral hospital. Correlations between SE severity and alterations in gray and white matter were studied. The association between severity of the SE and striatal dopaminergic deficits was also analyzed. Results: There was a significant negative correlation between the volumetric changes in the anterior cingulate cortex (ACC) and the inferior semilunar lobule of the cerebellum and the degree of SE. There was a significant correlation between the long association fibers (the superior longitudinal fasciculus, the uncinate fasciculus, and the inferior fronto-occipital fasciculus) connecting the frontal lobes to the temporal, parietal, and occipital lobes and SE. There was a significant negative correlation between SE in the more affected hand and the caudate dopamine transporter binding in the more affected hemisphere. Conclusions: Our results suggest that the ACC and the cerebellum (inferior semilunar lobule) are associated with the severity of SE. Taken together with DTI findings, the present study proposes that ACC may have an important role. Our data show that the caudate dopaminergic activity may be related to SE.",
author = "Eeksung Lee and Lee, {Ji Eun} and Kwangsun Yoo and Hong, {Jin Yong} and Jungsu Oh and Sunwoo, {Mun Kyung} and Kim, {Jae Seung} and Yong Jeong and Lee, {Phil Hyu} and Sohn, {Young Ho} and Kang, {Suk Yun}",
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Lee, E, Lee, JE, Yoo, K, Hong, JY, Oh, J, Sunwoo, MK, Kim, JS, Jeong, Y, Lee, PH, Sohn, YH & Kang, SY 2014, 'Neural correlates of progressive reduction of bradykinesia in de novo Parkinson's disease', Parkinsonism and Related Disorders, vol. 20, no. 12, pp. 1376-1381. https://doi.org/10.1016/j.parkreldis.2014.09.027

Neural correlates of progressive reduction of bradykinesia in de novo Parkinson's disease. / Lee, Eeksung; Lee, Ji Eun; Yoo, Kwangsun; Hong, Jin Yong; Oh, Jungsu; Sunwoo, Mun Kyung; Kim, Jae Seung; Jeong, Yong; Lee, Phil Hyu; Sohn, Young Ho; Kang, Suk Yun.

In: Parkinsonism and Related Disorders, Vol. 20, No. 12, 01.12.2014, p. 1376-1381.

Research output: Contribution to journalArticle

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T1 - Neural correlates of progressive reduction of bradykinesia in de novo Parkinson's disease

AU - Lee, Eeksung

AU - Lee, Ji Eun

AU - Yoo, Kwangsun

AU - Hong, Jin Yong

AU - Oh, Jungsu

AU - Sunwoo, Mun Kyung

AU - Kim, Jae Seung

AU - Jeong, Yong

AU - Lee, Phil Hyu

AU - Sohn, Young Ho

AU - Kang, Suk Yun

PY - 2014/12/1

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N2 - A progressive reduction in the speed and amplitude of repetitive action is an essential component of bradykinesia, which is called sequence effect (SE). Because SE is specific to Parkinson's disease (PD) and is suggested to be associated with motor arrest, its features are of great interest. The aim of this study was, for the first time, to find the neural correlates of SE and to demonstrate whether dopaminergic deficit is correlated with SE. Methods: We enrolled 12 patients with de novo PD at a tertiary referral hospital. Correlations between SE severity and alterations in gray and white matter were studied. The association between severity of the SE and striatal dopaminergic deficits was also analyzed. Results: There was a significant negative correlation between the volumetric changes in the anterior cingulate cortex (ACC) and the inferior semilunar lobule of the cerebellum and the degree of SE. There was a significant correlation between the long association fibers (the superior longitudinal fasciculus, the uncinate fasciculus, and the inferior fronto-occipital fasciculus) connecting the frontal lobes to the temporal, parietal, and occipital lobes and SE. There was a significant negative correlation between SE in the more affected hand and the caudate dopamine transporter binding in the more affected hemisphere. Conclusions: Our results suggest that the ACC and the cerebellum (inferior semilunar lobule) are associated with the severity of SE. Taken together with DTI findings, the present study proposes that ACC may have an important role. Our data show that the caudate dopaminergic activity may be related to SE.

AB - A progressive reduction in the speed and amplitude of repetitive action is an essential component of bradykinesia, which is called sequence effect (SE). Because SE is specific to Parkinson's disease (PD) and is suggested to be associated with motor arrest, its features are of great interest. The aim of this study was, for the first time, to find the neural correlates of SE and to demonstrate whether dopaminergic deficit is correlated with SE. Methods: We enrolled 12 patients with de novo PD at a tertiary referral hospital. Correlations between SE severity and alterations in gray and white matter were studied. The association between severity of the SE and striatal dopaminergic deficits was also analyzed. Results: There was a significant negative correlation between the volumetric changes in the anterior cingulate cortex (ACC) and the inferior semilunar lobule of the cerebellum and the degree of SE. There was a significant correlation between the long association fibers (the superior longitudinal fasciculus, the uncinate fasciculus, and the inferior fronto-occipital fasciculus) connecting the frontal lobes to the temporal, parietal, and occipital lobes and SE. There was a significant negative correlation between SE in the more affected hand and the caudate dopamine transporter binding in the more affected hemisphere. Conclusions: Our results suggest that the ACC and the cerebellum (inferior semilunar lobule) are associated with the severity of SE. Taken together with DTI findings, the present study proposes that ACC may have an important role. Our data show that the caudate dopaminergic activity may be related to SE.

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