Neural dynamics of olfactory perception: Low- And high-frequency modulations of local field potential spectra in mice revealed by an oddball stimulus

Jeungeun Kum, Jin Won Kim, Oliver Braubach, Jong Gyun Ha, Hyung Ju Cho, Chang Hoon Kim, Hio Been Han, Jee Hyun Choi, Joo Heon Yoon

Research output: Contribution to journalArticle

Abstract

Recent brain connectome studies have evidenced distinct and overlapping brain regions involved in processing olfactory perception. However, neural correlates of hypo- or anosmia in olfactory disorder patients are poorly known. Furthermore, the bottom-up and top-down processing of olfactory perception have not been well-documented, resulting in difficulty in locating the disease foci of olfactory disorder patients. The primary aim of this study is to characterize the bottom-up process of the neural dynamics across peripheral and central brain regions in anesthetized mice. We particularly focused on the neural oscillations of local field potential (LFP) in olfactory epithelium (OE), olfactory blub (OB), prefrontal cortex (PFC), and hippocampus (HC) during an olfactory oddball paradigm in urethane anesthetized mice. Odorant presentations evoked neural oscillations across slow and fast frequency bands including delta (1–4 Hz), theta (6–10 Hz), beta (15–30 Hz), low gamma (30–50 Hz), and high gamma (70–100 Hz) in both peripheral and central nervous systems, and the increases were more prominent in the infrequently presented odorant. During 5 s odorant exposures, the oscillatory responses in power were persistent in OE, OB, and PFC, whereas neural oscillations of HC increased only for short time at stimulus onset. These oscillatory responses in power were insignificant in both peripheral and central regions of the ZnSO4-treated anosmia model. These results suggest that olfactory stimulation induce LFP oscillations both in the peripheral and central nervous systems and suggest the possibility of linkage of LFP oscillations in the brain to the oscillations in the peripheral olfactory system.

Original languageEnglish
Article number478
JournalFrontiers in Neuroscience
Volume13
Issue numberMAY
DOIs
Publication statusPublished - 2019 Jan 1

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Olfactory Perception
Olfaction Disorders
Olfactory Mucosa
Peripheral Nervous System
Brain
Prefrontal Cortex
Hippocampus
Connectome
Central Nervous System
Urethane
Odorants

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kum, Jeungeun ; Kim, Jin Won ; Braubach, Oliver ; Ha, Jong Gyun ; Cho, Hyung Ju ; Kim, Chang Hoon ; Han, Hio Been ; Choi, Jee Hyun ; Yoon, Joo Heon. / Neural dynamics of olfactory perception : Low- And high-frequency modulations of local field potential spectra in mice revealed by an oddball stimulus. In: Frontiers in Neuroscience. 2019 ; Vol. 13, No. MAY.
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Neural dynamics of olfactory perception : Low- And high-frequency modulations of local field potential spectra in mice revealed by an oddball stimulus. / Kum, Jeungeun; Kim, Jin Won; Braubach, Oliver; Ha, Jong Gyun; Cho, Hyung Ju; Kim, Chang Hoon; Han, Hio Been; Choi, Jee Hyun; Yoon, Joo Heon.

In: Frontiers in Neuroscience, Vol. 13, No. MAY, 478, 01.01.2019.

Research output: Contribution to journalArticle

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