Neural predisposing factors of postoperative delirium in elderly patients with femoral neck fracture

Sunghyon Kyeong, Jung Eun Shin, Kyu Hyun Yang, Woo Suk Lee, Tae Sub Chung, Jae-Jin Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Elderly adults are more likely to develop delirium after major surgery, but there is limited knowledge of the vulnerability for postoperative delirium. In this study, we aimed to identify neural predisposing factors for postoperative delirium and develop a prediction model for estimating an individual's probability of postoperative delirium. Among 57 elderly participants with femoral neck fracture, 25 patients developed postoperative delirium and 32 patients did not. We preoperatively obtained data for clinical assessments, anatomical MRI, and resting-state functional MRI. Then we evaluated gray matter (GM) density, fractional anisotropy, and the amplitude of low-frequency fluctuation (ALFF), and conducted a group-level inference. The prediction models were developed to estimate an individual's probability using logistic regression. The group-level analysis revealed that neuroticism score, ALFF in the dorsolateral prefrontal cortex, and GM density in the caudate/suprachiasmatic nucleus were predisposing factors. The prediction model with these factors showed a correct classification rate of 86% using a leave-one-out cross-validation. The predicted probability computed from the logistic model was significantly correlated with delirium severity. These results suggest that the three components are the most important predisposing factors for postoperative delirium, and our prediction model may reflect the core pathophysiology in estimating the probability of postoperative delirium.

Original languageEnglish
Article number7602
JournalScientific reports
Volume8
Issue number1
DOIs
Publication statusPublished - 2018 Dec 1

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Femoral Neck Fractures
Delirium
Causality
Logistic Models
Suprachiasmatic Nucleus
Caudate Nucleus
Anisotropy
Prefrontal Cortex
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • General

Cite this

Kyeong, Sunghyon ; Shin, Jung Eun ; Yang, Kyu Hyun ; Lee, Woo Suk ; Chung, Tae Sub ; Kim, Jae-Jin. / Neural predisposing factors of postoperative delirium in elderly patients with femoral neck fracture. In: Scientific reports. 2018 ; Vol. 8, No. 1.
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Neural predisposing factors of postoperative delirium in elderly patients with femoral neck fracture. / Kyeong, Sunghyon; Shin, Jung Eun; Yang, Kyu Hyun; Lee, Woo Suk; Chung, Tae Sub; Kim, Jae-Jin.

In: Scientific reports, Vol. 8, No. 1, 7602, 01.12.2018.

Research output: Contribution to journalArticle

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