Neural responses to affective and cognitive theory of mind in children and adolescents with autism spectrum disorder

Eunjoo Kim, Sunghyon Kyeong, Keun Ah Cheon, Bumhee Park, Maeng Keun Oh, Ji Won Chun, Hae Jeong Park, Jae-Jin Kim, Dong Ho Song

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Children and adolescents with Autism Spectrum Disorder (ASD) are characterized by an impaired Theory of Mind (ToM). Recent evidence suggested that two aspects of ToM (cognitive ToM versus affective ToM) are differentially impaired in individuals with ASD. In this study, we examined the neural correlates of cognitive and affective ToM in children and adolescents with ASD compared to typically developing children (TDCs). Twelve children and adolescents with ASD and 12 age, IQ matched TDCs participated in this functional MRI study. The ToM task involved the attribution of cognitive and affective mental states to a cartoon character based on verbal and eye-gaze cues. In cognitive ToM tasks, ASD participants recruited the medial prefrontal cortex (mPFC), anterior cingulate cortex (ACC), and superior temporal gyrus (STG) to a greater extent than did TDCs. In affective ToM tasks, both ASD and TDC participants showed more activation in the insula and other subcortical regions than in cognitive ToM tasks. Correlational analysis revealed that greater activation of the mPFC/ACC regions was associated with less symptom severity in ASD patients. In sum, our study suggests that the recruitment of additional prefrontal resources can compensate for the successful behavioral performance in the ToM task in ASD participants.

Original languageEnglish
Pages (from-to)117-125
Number of pages9
JournalNeuroscience Letters
Volume621
DOIs
Publication statusPublished - 2016 May 16

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Theory of Mind
Gyrus Cinguli
Prefrontal Cortex
Autism Spectrum Disorder
Cartoons
Temporal Lobe
Cues
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Kim, Eunjoo ; Kyeong, Sunghyon ; Cheon, Keun Ah ; Park, Bumhee ; Oh, Maeng Keun ; Chun, Ji Won ; Park, Hae Jeong ; Kim, Jae-Jin ; Song, Dong Ho. / Neural responses to affective and cognitive theory of mind in children and adolescents with autism spectrum disorder. In: Neuroscience Letters. 2016 ; Vol. 621. pp. 117-125.
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Neural responses to affective and cognitive theory of mind in children and adolescents with autism spectrum disorder. / Kim, Eunjoo; Kyeong, Sunghyon; Cheon, Keun Ah; Park, Bumhee; Oh, Maeng Keun; Chun, Ji Won; Park, Hae Jeong; Kim, Jae-Jin; Song, Dong Ho.

In: Neuroscience Letters, Vol. 621, 16.05.2016, p. 117-125.

Research output: Contribution to journalArticle

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