Neural signal processing for closed-loop neuromodulation

Kwang Su Cha, Donghoon Yeo, Kyung Hwan Kim

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Purpose: The purpose of this article is to provide an overview of the current status of neural signal processing techniques for closed-loop neuromodulation. Methods: First we described overall structure of closed-loop neuromodulation systems. Then, the techniques for the stimulus artifact removal were explained, and the methods for neural state monitoring and biomarker extraction were described. Finally, the current status of neuromodulation based on neural signal processing was provided in detail. Results: Closed-loop neuromodulation system automatically adjusts stimulation parameters based on the brain response in real time. Adequate tools for signal sensing and signal processing can be used to obtain meaningful biomarkers reflecting the state of neural systems. Especially, an appropriate neural signal processing technique can optimize the details of stimulation for effective treatment of target disease. Conclusions: Neural signal-based biomarkers reflecting the pathophysiological statuses of patients are essential for closedloop neuromodulation, and they should be developed from an understanding of the relationship between clinical states and neural signals.

Original languageEnglish
Pages (from-to)113-122
Number of pages10
JournalBiomedical Engineering Letters
Volume6
Issue number3
DOIs
Publication statusPublished - 2016 Aug 1

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Signal processing
Biomarkers
Closed loop systems
Brain
Monitoring

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

Cha, Kwang Su ; Yeo, Donghoon ; Kim, Kyung Hwan. / Neural signal processing for closed-loop neuromodulation. In: Biomedical Engineering Letters. 2016 ; Vol. 6, No. 3. pp. 113-122.
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Neural signal processing for closed-loop neuromodulation. / Cha, Kwang Su; Yeo, Donghoon; Kim, Kyung Hwan.

In: Biomedical Engineering Letters, Vol. 6, No. 3, 01.08.2016, p. 113-122.

Research output: Contribution to journalReview article

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