Neurally induced umbilical cord blood cells modestly repair injured spinal cords

Sung Rae Cho; Mal Sook Yang; Sun Hee Yim; Jin Hee Park; Jong Eun Lee; Young Woo Eom; In Keun Jang; Hyo Eun Kim; Joon Seong Park; Hyun Ok Kim; Bae Hwan Lee; Chang Il Park; Young Jin Kim

doi:10.1097/WNR.0b013e3283089234

Neurally induced umbilical cord blood cells modestly repair injured spinal cords

Sung Rae Cho, Mal Sook Yang, Sun Hee Yim, Jin Hee Park, Jong Eun Lee, Young Woo Eom, In Keun Jang, Hyo Eun Kim, Joon Seong Park, Hyun Ok Kim, Bae Hwan Lee, Chang Il Park, Young Jin Kim

Department of Rehabilitation Medicine

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

Abstract

Umbilical cord blood (UCB) is known to have stem/progenitor cells.We earlier showed that novel progenitors could be isolated from cryopreserved human UCB with high e/ciency. The multipotent progenitor cells were induced to differentiate into neurallineage cells under the appropriate condition. In this study, we con¢rmed these neurally inducedprogenitor cells (NPCs), containing higher quantities of nerve growth factor, promoted functional recovery in ratswith spinal cordinjury (SCI). Sprague^Dawleyrats with SCI achieved a modest improvement in locomotor rating scale until 10 weeks after transplantation of the NPCs. SCI rats treatedwithNPCs also showed somatosensory-evoked potentials were recovered, andgrafted cells especially exhibited oligodendrocytic phenotype around the necrotic cavity.These ¢ndings suggest that UCB-NPCs might be a therapeutic resource to repair damaged spinal cords. NeuroReport 19:1259-1263

Original language	English
Pages (from-to)	1259-1263
Number of pages	5
Journal	NeuroReport
Volume	19
Issue number	13
DOIs	https://doi.org/10.1097/WNR.0b013e3283089234
Publication status	Published - 2008 Aug 27

All Science Journal Classification (ASJC) codes

Neuroscience(all)

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10.1097/WNR.0b013e3283089234

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title = "Neurally induced umbilical cord blood cells modestly repair injured spinal cords",

abstract = "Umbilical cord blood (UCB) is known to have stem/progenitor cells.We earlier showed that novel progenitors could be isolated from cryopreserved human UCB with high e/ciency. The multipotent progenitor cells were induced to differentiate into neurallineage cells under the appropriate condition. In this study, we con¢rmed these neurally inducedprogenitor cells (NPCs), containing higher quantities of nerve growth factor, promoted functional recovery in ratswith spinal cordinjury (SCI). Sprague^Dawleyrats with SCI achieved a modest improvement in locomotor rating scale until 10 weeks after transplantation of the NPCs. SCI rats treatedwithNPCs also showed somatosensory-evoked potentials were recovered, andgrafted cells especially exhibited oligodendrocytic phenotype around the necrotic cavity.These ¢ndings suggest that UCB-NPCs might be a therapeutic resource to repair damaged spinal cords. NeuroReport 19:1259-1263",

author = "Cho, {Sung Rae} and Yang, {Mal Sook} and Yim, {Sun Hee} and Park, {Jin Hee} and Lee, {Jong Eun} and Eom, {Young Woo} and Jang, {In Keun} and Kim, {Hyo Eun} and Park, {Joon Seong} and Kim, {Hyun Ok} and Lee, {Bae Hwan} and Park, {Chang Il} and Kim, {Young Jin}",

year = "2008",

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doi = "10.1097/WNR.0b013e3283089234",

language = "English",

volume = "19",

pages = "1259--1263",

journal = "NeuroReport",

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Neurally induced umbilical cord blood cells modestly repair injured spinal cords. / Cho, Sung Rae; Yang, Mal Sook; Yim, Sun Hee; Park, Jin Hee; Lee, Jong Eun; Eom, Young Woo; Jang, In Keun; Kim, Hyo Eun; Park, Joon Seong; Kim, Hyun Ok; Lee, Bae Hwan; Park, Chang Il; Kim, Young Jin.

In: NeuroReport, Vol. 19, No. 13, 27.08.2008, p. 1259-1263.

Research output: Contribution to journal › Article › peer-review

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AU - Yang, Mal Sook

AU - Yim, Sun Hee

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AU - Eom, Young Woo

AU - Jang, In Keun

AU - Kim, Hyo Eun

AU - Park, Joon Seong

AU - Kim, Hyun Ok

AU - Lee, Bae Hwan

AU - Park, Chang Il

AU - Kim, Young Jin

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Neurally induced umbilical cord blood cells modestly repair injured spinal cords

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