Abstract
Umbilical cord blood (UCB) is known to have stem/progenitor cells.We earlier showed that novel progenitors could be isolated from cryopreserved human UCB with high e/ciency. The multipotent progenitor cells were induced to differentiate into neurallineage cells under the appropriate condition. In this study, we con¢rmed these neurally inducedprogenitor cells (NPCs), containing higher quantities of nerve growth factor, promoted functional recovery in ratswith spinal cordinjury (SCI). Sprague^Dawleyrats with SCI achieved a modest improvement in locomotor rating scale until 10 weeks after transplantation of the NPCs. SCI rats treatedwithNPCs also showed somatosensory-evoked potentials were recovered, andgrafted cells especially exhibited oligodendrocytic phenotype around the necrotic cavity.These ¢ndings suggest that UCB-NPCs might be a therapeutic resource to repair damaged spinal cords. NeuroReport 19:1259-1263
Original language | English |
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Pages (from-to) | 1259-1263 |
Number of pages | 5 |
Journal | NeuroReport |
Volume | 19 |
Issue number | 13 |
DOIs | |
Publication status | Published - 2008 Aug 27 |
All Science Journal Classification (ASJC) codes
- Neuroscience(all)