Neurally induced umbilical cord blood cells modestly repair injured spinal cords

Sung Rae Cho, Mal Sook Yang, Sun Hee Yim, Jin Hee Park, Jong Eun Lee, Young Woo Eom, In Keun Jang, Hyo Eun Kim, Joon Seong Park, Hyun Ok Kim, Bae Hwan Lee, Chang Il Park, Young Jin Kim

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Abstract

Umbilical cord blood (UCB) is known to have stem/progenitor cells.We earlier showed that novel progenitors could be isolated from cryopreserved human UCB with high e/ciency. The multipotent progenitor cells were induced to differentiate into neurallineage cells under the appropriate condition. In this study, we con¢rmed these neurally inducedprogenitor cells (NPCs), containing higher quantities of nerve growth factor, promoted functional recovery in ratswith spinal cordinjury (SCI). Sprague^Dawleyrats with SCI achieved a modest improvement in locomotor rating scale until 10 weeks after transplantation of the NPCs. SCI rats treatedwithNPCs also showed somatosensory-evoked potentials were recovered, andgrafted cells especially exhibited oligodendrocytic phenotype around the necrotic cavity.These ¢ndings suggest that UCB-NPCs might be a therapeutic resource to repair damaged spinal cords. NeuroReport 19:1259-1263

Original languageEnglish
Pages (from-to)1259-1263
Number of pages5
JournalNeuroReport
Volume19
Issue number13
DOIs
Publication statusPublished - 2008 Aug 27

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Cho, S. R., Yang, M. S., Yim, S. H., Park, J. H., Lee, J. E., Eom, Y. W., Jang, I. K., Kim, H. E., Park, J. S., Kim, H. O., Lee, B. H., Park, C. I., & Kim, Y. J. (2008). Neurally induced umbilical cord blood cells modestly repair injured spinal cords. NeuroReport, 19(13), 1259-1263. https://doi.org/10.1097/WNR.0b013e3283089234