Abstract
Umbilical cord blood (UCB) is known to have stem/progenitor cells.We earlier showed that novel progenitors could be isolated from cryopreserved human UCB with high e/ciency. The multipotent progenitor cells were induced to differentiate into neurallineage cells under the appropriate condition. In this study, we con¢rmed these neurally inducedprogenitor cells (NPCs), containing higher quantities of nerve growth factor, promoted functional recovery in ratswith spinal cordinjury (SCI). Sprague^Dawleyrats with SCI achieved a modest improvement in locomotor rating scale until 10 weeks after transplantation of the NPCs. SCI rats treatedwithNPCs also showed somatosensory-evoked potentials were recovered, andgrafted cells especially exhibited oligodendrocytic phenotype around the necrotic cavity.These ¢ndings suggest that UCB-NPCs might be a therapeutic resource to repair damaged spinal cords. NeuroReport 19:1259-1263
| Original language | English |
|---|---|
| Pages (from-to) | 1259-1263 |
| Number of pages | 5 |
| Journal | NeuroReport |
| Volume | 19 |
| Issue number | 13 |
| DOIs | |
| Publication status | Published - 2008 Aug 27 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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Neurally induced umbilical cord blood cells modestly repair injured spinal cords. / Cho, Sung Rae; Yang, Mal Sook; Yim, Sun Hee; Park, Jin Hee; Lee, Jong Eun; Eom, Young Woo; Jang, In Keun; Kim, Hyo Eun; Park, Joon Seong; Kim, Hyun Ok; Lee, Bae Hwan; Park, Chang Il; Kim, Young Jin.
In: NeuroReport, Vol. 19, No. 13, 27.08.2008, p. 1259-1263.Research output: Contribution to journal › Article
TY - JOUR
T1 - Neurally induced umbilical cord blood cells modestly repair injured spinal cords
AU - Cho, Sung Rae
AU - Yang, Mal Sook
AU - Yim, Sun Hee
AU - Park, Jin Hee
AU - Lee, Jong Eun
AU - Eom, Young Woo
AU - Jang, In Keun
AU - Kim, Hyo Eun
AU - Park, Joon Seong
AU - Kim, Hyun Ok
AU - Lee, Bae Hwan
AU - Park, Chang Il
AU - Kim, Young Jin
PY - 2008/8/27
Y1 - 2008/8/27
N2 - Umbilical cord blood (UCB) is known to have stem/progenitor cells.We earlier showed that novel progenitors could be isolated from cryopreserved human UCB with high e/ciency. The multipotent progenitor cells were induced to differentiate into neurallineage cells under the appropriate condition. In this study, we con¢rmed these neurally inducedprogenitor cells (NPCs), containing higher quantities of nerve growth factor, promoted functional recovery in ratswith spinal cordinjury (SCI). Sprague^Dawleyrats with SCI achieved a modest improvement in locomotor rating scale until 10 weeks after transplantation of the NPCs. SCI rats treatedwithNPCs also showed somatosensory-evoked potentials were recovered, andgrafted cells especially exhibited oligodendrocytic phenotype around the necrotic cavity.These ¢ndings suggest that UCB-NPCs might be a therapeutic resource to repair damaged spinal cords. NeuroReport 19:1259-1263
AB - Umbilical cord blood (UCB) is known to have stem/progenitor cells.We earlier showed that novel progenitors could be isolated from cryopreserved human UCB with high e/ciency. The multipotent progenitor cells were induced to differentiate into neurallineage cells under the appropriate condition. In this study, we con¢rmed these neurally inducedprogenitor cells (NPCs), containing higher quantities of nerve growth factor, promoted functional recovery in ratswith spinal cordinjury (SCI). Sprague^Dawleyrats with SCI achieved a modest improvement in locomotor rating scale until 10 weeks after transplantation of the NPCs. SCI rats treatedwithNPCs also showed somatosensory-evoked potentials were recovered, andgrafted cells especially exhibited oligodendrocytic phenotype around the necrotic cavity.These ¢ndings suggest that UCB-NPCs might be a therapeutic resource to repair damaged spinal cords. NeuroReport 19:1259-1263
UR - http://www.scopus.com/inward/record.url?scp=52649085337&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=52649085337&partnerID=8YFLogxK
U2 - 10.1097/WNR.0b013e3283089234
DO - 10.1097/WNR.0b013e3283089234
M3 - Article
C2 - 18695504
AN - SCOPUS:52649085337
VL - 19
SP - 1259
EP - 1263
JO - NeuroReport
JF - NeuroReport
SN - 0959-4965
IS - 13
ER -