Neuraminidase Inhibitors from the Roots of Caragana sinica

Seon Ju Park; Nanyoung Kim; Nguyen Xuan Nhiem; Hee Jae Kwak; Hyun Wook Yang; Seung Hyun Kim

doi:10.1002/cbdv.202000470

Neuraminidase Inhibitors from the Roots of Caragana sinica

Seon Ju Park, Nanyoung Kim, Nguyen Xuan Nhiem, Hee Jae Kwak, Hyun Wook Yang, Seung Hyun Kim

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

Two new oligostilbenes, caragasinins D and E, along with four known compounds, kobophenol A, α-viniferin, wistin, and 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid, were isolated from the roots of Caragana sinica. These compounds were spectroscopically analyzed for their structures and configurations and compared with existing data. The configurations of caragasinins D and E were elucidated by ¹H-NMR spectroscopy, CD spectroscopy, and time-dependent density-functional theory simulated ECD spectral data. All six compounds were evaluated for their inhibitory activity against neuraminidase (NA) from Clostridium perfringens. Among the tested compounds, 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid demonstrated statistically significant NA inhibitory activity, which was comparable to the positive control, mangiferin.

Original language	English
Article number	e2000470
Journal	Chemistry and Biodiversity
Volume	17
Issue number	11
DOIs	https://doi.org/10.1002/cbdv.202000470
Publication status	Published - 2020 Nov

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant [NRF‐2020R1A2C1012632 and NRF‐2017R1A6A3A11029000] funded by the Ministry of Education, Science and Technology, Republic of Korea.

Publisher Copyright:
© 2020 Wiley-VHCA AG, Zurich, Switzerland

All Science Journal Classification (ASJC) codes

Bioengineering
Biochemistry
Chemistry(all)
Molecular Medicine
Molecular Biology

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title = "Neuraminidase Inhibitors from the Roots of Caragana sinica",

abstract = "Two new oligostilbenes, caragasinins D and E, along with four known compounds, kobophenol A, α-viniferin, wistin, and 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid, were isolated from the roots of Caragana sinica. These compounds were spectroscopically analyzed for their structures and configurations and compared with existing data. The configurations of caragasinins D and E were elucidated by 1H-NMR spectroscopy, CD spectroscopy, and time-dependent density-functional theory simulated ECD spectral data. All six compounds were evaluated for their inhibitory activity against neuraminidase (NA) from Clostridium perfringens. Among the tested compounds, 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid demonstrated statistically significant NA inhibitory activity, which was comparable to the positive control, mangiferin.",

author = "Park, {Seon Ju} and Nanyoung Kim and Nhiem, {Nguyen Xuan} and Kwak, {Hee Jae} and Yang, {Hyun Wook} and Kim, {Seung Hyun}",

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doi = "10.1002/cbdv.202000470",

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AU - Kwak, Hee Jae

AU - Yang, Hyun Wook

AU - Kim, Seung Hyun

N1 - Funding Information: This work was supported by the National Research Foundation of Korea (NRF) grant [NRF‐2020R1A2C1012632 and NRF‐2017R1A6A3A11029000] funded by the Ministry of Education, Science and Technology, Republic of Korea. Publisher Copyright: © 2020 Wiley-VHCA AG, Zurich, Switzerland

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N2 - Two new oligostilbenes, caragasinins D and E, along with four known compounds, kobophenol A, α-viniferin, wistin, and 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid, were isolated from the roots of Caragana sinica. These compounds were spectroscopically analyzed for their structures and configurations and compared with existing data. The configurations of caragasinins D and E were elucidated by 1H-NMR spectroscopy, CD spectroscopy, and time-dependent density-functional theory simulated ECD spectral data. All six compounds were evaluated for their inhibitory activity against neuraminidase (NA) from Clostridium perfringens. Among the tested compounds, 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid demonstrated statistically significant NA inhibitory activity, which was comparable to the positive control, mangiferin.

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Neuraminidase Inhibitors from the Roots of Caragana sinica

Abstract

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