Neuraminidase Inhibitors from the Roots of Caragana sinica

Seon Ju Park, Nanyoung Kim, Nguyen Xuan Nhiem, Hee Jae Kwak, Hyun Wook Yang, Seung Hyun Kim

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Two new oligostilbenes, caragasinins D and E, along with four known compounds, kobophenol A, α-viniferin, wistin, and 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid, were isolated from the roots of Caragana sinica. These compounds were spectroscopically analyzed for their structures and configurations and compared with existing data. The configurations of caragasinins D and E were elucidated by 1H-NMR spectroscopy, CD spectroscopy, and time-dependent density-functional theory simulated ECD spectral data. All six compounds were evaluated for their inhibitory activity against neuraminidase (NA) from Clostridium perfringens. Among the tested compounds, 5-hydroxy-2-[(4-hydroxyphenyl)acetyl]-3-methoxybenzoic acid demonstrated statistically significant NA inhibitory activity, which was comparable to the positive control, mangiferin.

Original languageEnglish
Article numbere2000470
JournalChemistry and Biodiversity
Issue number11
Publication statusPublished - 2020 Nov

Bibliographical note

Funding Information:
This work was supported by the National Research Foundation of Korea (NRF) grant [NRF‐2020R1A2C1012632 and NRF‐2017R1A6A3A11029000] funded by the Ministry of Education, Science and Technology, Republic of Korea.

Publisher Copyright:
© 2020 Wiley-VHCA AG, Zurich, Switzerland

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Molecular Medicine
  • Molecular Biology


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