Neuraminidase inhibitory activity by compounds isolated from aerial parts of Rhinacanthus nasutus

Hee Jae Kwak, Seon Ju Park, Nanyoung Kim, Guijae Yoo, Jun Hyung Park, Youngse Oh, Nguyen Xuan Nhiem, Seung Hyun Kim

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of various diseases, such as cancer, fungal infections, herpes virus infections and several types of skin diseases in South-East Asian countries. In this study, eight compounds 1–8 were isolated from the aerial parts of R. nasutus. The structures of compounds were determined by the spectroscopic methods, including 1D and 2D NMR. The isolated compounds were evaluated for neuraminidase inhibitory activity. Several lignans, 2,3-bis[(4-hydroxy-3,5-dimethoxyphenyl)methyl]-1,4-butanediol (5) and 8,8′-bisdihydrosiringenin glucoside (6), significantly inhibited neuraminidase activity, which was comparable to the positive controls, mangiferin and oseltamivir. In addition, a structure-based virtual screening against neuraminidase using bioactive components was demonstrated.

Original languageEnglish
Pages (from-to)2111-2115
Number of pages5
JournalNatural Product Research
Volume32
Issue number17
DOIs
Publication statusPublished - 2018 Sep 2

Fingerprint

sialidase
Neuraminidase
aerial parts
Antennas
Acanthaceae
Oseltamivir
butanediol
Lignans
Mycoses
Glucosides
skin diseases
lignans
Traditional Medicine
Virus Diseases
traditional medicine
Viruses
South East Asia
Skin Diseases
infection
Medicine

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

Cite this

Kwak, Hee Jae ; Park, Seon Ju ; Kim, Nanyoung ; Yoo, Guijae ; Park, Jun Hyung ; Oh, Youngse ; Nhiem, Nguyen Xuan ; Kim, Seung Hyun. / Neuraminidase inhibitory activity by compounds isolated from aerial parts of Rhinacanthus nasutus. In: Natural Product Research. 2018 ; Vol. 32, No. 17. pp. 2111-2115.
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Neuraminidase inhibitory activity by compounds isolated from aerial parts of Rhinacanthus nasutus. / Kwak, Hee Jae; Park, Seon Ju; Kim, Nanyoung; Yoo, Guijae; Park, Jun Hyung; Oh, Youngse; Nhiem, Nguyen Xuan; Kim, Seung Hyun.

In: Natural Product Research, Vol. 32, No. 17, 02.09.2018, p. 2111-2115.

Research output: Contribution to journalArticle

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