Rhinacanthus nasutus (L.) Kurz (Acanthaceae) is known as traditional medicine for the treatment of various diseases, such as cancer, fungal infections, herpes virus infections and several types of skin diseases in South-East Asian countries. In this study, eight compounds 1–8 were isolated from the aerial parts of R. nasutus. The structures of compounds were determined by the spectroscopic methods, including 1D and 2D NMR. The isolated compounds were evaluated for neuraminidase inhibitory activity. Several lignans, 2,3-bis[(4-hydroxy-3,5-dimethoxyphenyl)methyl]-1,4-butanediol (5) and 8,8′-bisdihydrosiringenin glucoside (6), significantly inhibited neuraminidase activity, which was comparable to the positive controls, mangiferin and oseltamivir. In addition, a structure-based virtual screening against neuraminidase using bioactive components was demonstrated.
|Number of pages||5|
|Journal||Natural Product Research|
|Publication status||Published - 2018 Sept 2|
Bibliographical noteFunding Information:
This research was supported by the National Research Foundation of Korea (NRF) [grant number NRF-2016R1A2B4006742] funded by the Ministry of Education, Science and Technology, Republic of Korea.
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All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Plant Science
- Organic Chemistry