Neuroanatomic basis of amnestic MCI differs in patients with and without Parkinson disease

J. E. Lee, H. J. Park, S. K. Song, Y. H. Sohn, J. D. Lee, P. H. Lee

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Objective: To explore the neuroanatomic basis of amnestic mild cognitive impairment (aMCI) in patients with Parkinson disease (PD; aMCI-PD) and without PD (aMCI-PD). Methods: A total of 119 patients with aMCI (aMCI-PD, n = 78, and aMCI-PD, n = 41) underwent T1-weighted MRI, and the image data were analyzed using voxel-based morphometry. Results: No significant differences in demographic characteristics or general cognition were found between patients with aMCI-PD and aMCI-PD. Comparisons of neuropsychological tests between groups revealed that patients with aMCI-PD had lower scores in delayed verbal and visual recognition memory, whereas visuospatial dysfunction was more severe in patients with aMCI-PD. Gray matter (GM) density in the right temporal and posterior cingular cortices was significantly lower in the aMCI-PD group compared with controls. In contrast, GM density in the aMCI-PD group was significantly lower in the precuneus and left prefrontal and primary motor areas relative to controls. A direct comparison between groups showed that decreased GM density in aMCI-PD relative to aMCI-PD was localized in the right temporal and anterior prefrontal areas, whereas decreased GM density in aMCI-PD relative to aMCI-PD was involved in the bilateral precuneus, left primary motor, and right parietal areas. Memory decline was correlated with temporal area atrophy in aMCI-PD and with posterior cingulate cortex atrophy in aMCI-PD. ConclusionS: Our data suggest that different neuroanatomic systems underlie memory dysfunction in patients with aMCI-PD and aMCI-PD.

Original languageEnglish
Pages (from-to)2009-2016
Number of pages8
JournalNeurology
Volume75
Issue number22
DOIs
Publication statusPublished - 2010 Nov 30

Fingerprint

Parkinson Disease
Cognitive Dysfunction
Parietal Lobe
Atrophy
Neuropsychological Tests
Gyrus Cinguli
Motor Cortex
Cognition

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Lee, J. E. ; Park, H. J. ; Song, S. K. ; Sohn, Y. H. ; Lee, J. D. ; Lee, P. H. / Neuroanatomic basis of amnestic MCI differs in patients with and without Parkinson disease. In: Neurology. 2010 ; Vol. 75, No. 22. pp. 2009-2016.
@article{88eae0e6248e401eb2b66fe2f302ecf1,
title = "Neuroanatomic basis of amnestic MCI differs in patients with and without Parkinson disease",
abstract = "Objective: To explore the neuroanatomic basis of amnestic mild cognitive impairment (aMCI) in patients with Parkinson disease (PD; aMCI-PD) and without PD (aMCI-PD). Methods: A total of 119 patients with aMCI (aMCI-PD, n = 78, and aMCI-PD, n = 41) underwent T1-weighted MRI, and the image data were analyzed using voxel-based morphometry. Results: No significant differences in demographic characteristics or general cognition were found between patients with aMCI-PD and aMCI-PD. Comparisons of neuropsychological tests between groups revealed that patients with aMCI-PD had lower scores in delayed verbal and visual recognition memory, whereas visuospatial dysfunction was more severe in patients with aMCI-PD. Gray matter (GM) density in the right temporal and posterior cingular cortices was significantly lower in the aMCI-PD group compared with controls. In contrast, GM density in the aMCI-PD group was significantly lower in the precuneus and left prefrontal and primary motor areas relative to controls. A direct comparison between groups showed that decreased GM density in aMCI-PD relative to aMCI-PD was localized in the right temporal and anterior prefrontal areas, whereas decreased GM density in aMCI-PD relative to aMCI-PD was involved in the bilateral precuneus, left primary motor, and right parietal areas. Memory decline was correlated with temporal area atrophy in aMCI-PD and with posterior cingulate cortex atrophy in aMCI-PD. ConclusionS: Our data suggest that different neuroanatomic systems underlie memory dysfunction in patients with aMCI-PD and aMCI-PD.",
author = "Lee, {J. E.} and Park, {H. J.} and Song, {S. K.} and Sohn, {Y. H.} and Lee, {J. D.} and Lee, {P. H.}",
year = "2010",
month = "11",
day = "30",
doi = "10.1212/WNL.0b013e3181ff96bf",
language = "English",
volume = "75",
pages = "2009--2016",
journal = "Neurology",
issn = "0028-3878",
publisher = "Lippincott Williams and Wilkins",
number = "22",

}

Neuroanatomic basis of amnestic MCI differs in patients with and without Parkinson disease. / Lee, J. E.; Park, H. J.; Song, S. K.; Sohn, Y. H.; Lee, J. D.; Lee, P. H.

In: Neurology, Vol. 75, No. 22, 30.11.2010, p. 2009-2016.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neuroanatomic basis of amnestic MCI differs in patients with and without Parkinson disease

AU - Lee, J. E.

AU - Park, H. J.

AU - Song, S. K.

AU - Sohn, Y. H.

AU - Lee, J. D.

AU - Lee, P. H.

PY - 2010/11/30

Y1 - 2010/11/30

N2 - Objective: To explore the neuroanatomic basis of amnestic mild cognitive impairment (aMCI) in patients with Parkinson disease (PD; aMCI-PD) and without PD (aMCI-PD). Methods: A total of 119 patients with aMCI (aMCI-PD, n = 78, and aMCI-PD, n = 41) underwent T1-weighted MRI, and the image data were analyzed using voxel-based morphometry. Results: No significant differences in demographic characteristics or general cognition were found between patients with aMCI-PD and aMCI-PD. Comparisons of neuropsychological tests between groups revealed that patients with aMCI-PD had lower scores in delayed verbal and visual recognition memory, whereas visuospatial dysfunction was more severe in patients with aMCI-PD. Gray matter (GM) density in the right temporal and posterior cingular cortices was significantly lower in the aMCI-PD group compared with controls. In contrast, GM density in the aMCI-PD group was significantly lower in the precuneus and left prefrontal and primary motor areas relative to controls. A direct comparison between groups showed that decreased GM density in aMCI-PD relative to aMCI-PD was localized in the right temporal and anterior prefrontal areas, whereas decreased GM density in aMCI-PD relative to aMCI-PD was involved in the bilateral precuneus, left primary motor, and right parietal areas. Memory decline was correlated with temporal area atrophy in aMCI-PD and with posterior cingulate cortex atrophy in aMCI-PD. ConclusionS: Our data suggest that different neuroanatomic systems underlie memory dysfunction in patients with aMCI-PD and aMCI-PD.

AB - Objective: To explore the neuroanatomic basis of amnestic mild cognitive impairment (aMCI) in patients with Parkinson disease (PD; aMCI-PD) and without PD (aMCI-PD). Methods: A total of 119 patients with aMCI (aMCI-PD, n = 78, and aMCI-PD, n = 41) underwent T1-weighted MRI, and the image data were analyzed using voxel-based morphometry. Results: No significant differences in demographic characteristics or general cognition were found between patients with aMCI-PD and aMCI-PD. Comparisons of neuropsychological tests between groups revealed that patients with aMCI-PD had lower scores in delayed verbal and visual recognition memory, whereas visuospatial dysfunction was more severe in patients with aMCI-PD. Gray matter (GM) density in the right temporal and posterior cingular cortices was significantly lower in the aMCI-PD group compared with controls. In contrast, GM density in the aMCI-PD group was significantly lower in the precuneus and left prefrontal and primary motor areas relative to controls. A direct comparison between groups showed that decreased GM density in aMCI-PD relative to aMCI-PD was localized in the right temporal and anterior prefrontal areas, whereas decreased GM density in aMCI-PD relative to aMCI-PD was involved in the bilateral precuneus, left primary motor, and right parietal areas. Memory decline was correlated with temporal area atrophy in aMCI-PD and with posterior cingulate cortex atrophy in aMCI-PD. ConclusionS: Our data suggest that different neuroanatomic systems underlie memory dysfunction in patients with aMCI-PD and aMCI-PD.

UR - http://www.scopus.com/inward/record.url?scp=78650022530&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=78650022530&partnerID=8YFLogxK

U2 - 10.1212/WNL.0b013e3181ff96bf

DO - 10.1212/WNL.0b013e3181ff96bf

M3 - Article

C2 - 21115956

AN - SCOPUS:78650022530

VL - 75

SP - 2009

EP - 2016

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 22

ER -