Abstract
The aim of this study was to characterize the association between trait anhedonia and regional gray matter volume in patients with schizophrenia. Forty-six patients with schizophrenia and 56 healthy controls underwent magnetic resonance imaging (MRI) to acquire high-resolution T1-weighted images. Trait anhedonia was measured using the Chapman Revised Physical Anhedonia Scale (PAS). Voxel-based morphometry was performed to investigate brain volume correlates of trait anhedonia. Several brain regions in the patient group, including the left precuneus and right posterior cingulate (PCC), were found to show significantly less correlation with PAS scores than those of the control group. Post-hoc analysis revealed that negative correlations between the regional gray matter volume and the PAS scores in the patient group were found at a trend level in the left precuneus and the right PCC. In conclusion, these findings suggest that trait anhedonia in patients with schizophrenia could possibly be associated with a volume deficit in brain regions related to default-mode, which reflects the impairment of self-referential processing and reward anticipation.
| Original language | English |
|---|---|
| Pages (from-to) | 110-114 |
| Number of pages | 5 |
| Journal | Neuroscience Letters |
| Volume | 489 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2011 Feb 4 |
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All Science Journal Classification (ASJC) codes
- Neuroscience(all)
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Neuroanatomical correlates of trait anhedonia in patients with schizophrenia : A voxel-based morphometric study. / Lee, Jung Suk; Park, Hae Jeong; Chun, Ji Won; Seok, Jeong Ho; Park, Il Ho; Park, Bumhee; Kim, Jae-Jin.
In: Neuroscience Letters, Vol. 489, No. 2, 04.02.2011, p. 110-114.Research output: Contribution to journal › Article
TY - JOUR
T1 - Neuroanatomical correlates of trait anhedonia in patients with schizophrenia
T2 - A voxel-based morphometric study
AU - Lee, Jung Suk
AU - Park, Hae Jeong
AU - Chun, Ji Won
AU - Seok, Jeong Ho
AU - Park, Il Ho
AU - Park, Bumhee
AU - Kim, Jae-Jin
PY - 2011/2/4
Y1 - 2011/2/4
N2 - The aim of this study was to characterize the association between trait anhedonia and regional gray matter volume in patients with schizophrenia. Forty-six patients with schizophrenia and 56 healthy controls underwent magnetic resonance imaging (MRI) to acquire high-resolution T1-weighted images. Trait anhedonia was measured using the Chapman Revised Physical Anhedonia Scale (PAS). Voxel-based morphometry was performed to investigate brain volume correlates of trait anhedonia. Several brain regions in the patient group, including the left precuneus and right posterior cingulate (PCC), were found to show significantly less correlation with PAS scores than those of the control group. Post-hoc analysis revealed that negative correlations between the regional gray matter volume and the PAS scores in the patient group were found at a trend level in the left precuneus and the right PCC. In conclusion, these findings suggest that trait anhedonia in patients with schizophrenia could possibly be associated with a volume deficit in brain regions related to default-mode, which reflects the impairment of self-referential processing and reward anticipation.
AB - The aim of this study was to characterize the association between trait anhedonia and regional gray matter volume in patients with schizophrenia. Forty-six patients with schizophrenia and 56 healthy controls underwent magnetic resonance imaging (MRI) to acquire high-resolution T1-weighted images. Trait anhedonia was measured using the Chapman Revised Physical Anhedonia Scale (PAS). Voxel-based morphometry was performed to investigate brain volume correlates of trait anhedonia. Several brain regions in the patient group, including the left precuneus and right posterior cingulate (PCC), were found to show significantly less correlation with PAS scores than those of the control group. Post-hoc analysis revealed that negative correlations between the regional gray matter volume and the PAS scores in the patient group were found at a trend level in the left precuneus and the right PCC. In conclusion, these findings suggest that trait anhedonia in patients with schizophrenia could possibly be associated with a volume deficit in brain regions related to default-mode, which reflects the impairment of self-referential processing and reward anticipation.
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UR - http://www.scopus.com/inward/citedby.url?scp=78651447490&partnerID=8YFLogxK
U2 - 10.1016/j.neulet.2010.11.076
DO - 10.1016/j.neulet.2010.11.076
M3 - Article
C2 - 21138755
AN - SCOPUS:78651447490
VL - 489
SP - 110
EP - 114
JO - Neuroscience Letters
JF - Neuroscience Letters
SN - 0304-3940
IS - 2
ER -