Neurocutaneous melanosis presenting as chronic partial epilepsy

Byoung Seok Ye, Yang Je Cho, Sang Hyun Jang, Byung In Lee, Kyoung Heo, Hyun Ho Jung, JinWoo Chang, SeHoon Kim

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Background: Neurocutaneous melanosis (NCM) is a rare neurocutaneous syndrome characterized by the presence of multiple congenital melanocytic nevi (CMN) and the proliferation of melanocytes in the central nervous system, usually involving the leptomeninges. Chronic partial epilepsy as a sole manifestation is rare in NCM. Case Report A 32-year-old man suffering from chronic partial epilepsy presented with multiple CMN on his trunk and scalp. Brain MRI demonstrated a focal lesion in the right amygdala that was consistent with interictal epileptiform discharges in the right temporal region on electroencephalography (EEG). An anterior temporal lobectomy was performed, and the pathology investigation revealed numerous melanophages in the amygdala. The patient was seizure-free after surgery. Conclusions: We report a patient with NCM presenting as chronic partial epilepsy who was successfully treated by anterior temporal lobectomy.

Original languageEnglish
Pages (from-to)134-137
Number of pages4
JournalJournal of Clinical Neurology (Korea)
Volume4
Issue number3
DOIs
Publication statusPublished - 2008 Jan 1

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Partial Epilepsy
Anterior Temporal Lobectomy
Pigmented Nevus
Amygdala
Neurocutaneous Syndromes
Melanocytes
Temporal Lobe
Scalp
Electroencephalography
Seizures
Central Nervous System
Pathology
Brain
Neurocutaneous melanosis

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Ye, Byoung Seok ; Cho, Yang Je ; Jang, Sang Hyun ; Lee, Byung In ; Heo, Kyoung ; Jung, Hyun Ho ; Chang, JinWoo ; Kim, SeHoon. / Neurocutaneous melanosis presenting as chronic partial epilepsy. In: Journal of Clinical Neurology (Korea). 2008 ; Vol. 4, No. 3. pp. 134-137.
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Neurocutaneous melanosis presenting as chronic partial epilepsy. / Ye, Byoung Seok; Cho, Yang Je; Jang, Sang Hyun; Lee, Byung In; Heo, Kyoung; Jung, Hyun Ho; Chang, JinWoo; Kim, SeHoon.

In: Journal of Clinical Neurology (Korea), Vol. 4, No. 3, 01.01.2008, p. 134-137.

Research output: Contribution to journalArticle

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T1 - Neurocutaneous melanosis presenting as chronic partial epilepsy

AU - Ye, Byoung Seok

AU - Cho, Yang Je

AU - Jang, Sang Hyun

AU - Lee, Byung In

AU - Heo, Kyoung

AU - Jung, Hyun Ho

AU - Chang, JinWoo

AU - Kim, SeHoon

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AB - Background: Neurocutaneous melanosis (NCM) is a rare neurocutaneous syndrome characterized by the presence of multiple congenital melanocytic nevi (CMN) and the proliferation of melanocytes in the central nervous system, usually involving the leptomeninges. Chronic partial epilepsy as a sole manifestation is rare in NCM. Case Report A 32-year-old man suffering from chronic partial epilepsy presented with multiple CMN on his trunk and scalp. Brain MRI demonstrated a focal lesion in the right amygdala that was consistent with interictal epileptiform discharges in the right temporal region on electroencephalography (EEG). An anterior temporal lobectomy was performed, and the pathology investigation revealed numerous melanophages in the amygdala. The patient was seizure-free after surgery. Conclusions: We report a patient with NCM presenting as chronic partial epilepsy who was successfully treated by anterior temporal lobectomy.

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