Neurological adverse event profile of magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor

Paul S. Fishman, W. Jeffrey Elias, Pejman Ghanouni, Ryder Gwinn, Nir Lipsman, Michael Schwartz, Jin W. Chang, Takaomi Taira, Vibhor Krishna, Ali Rezai, Kazumichi Yamada, Keiji Igase, Rees Cosgrove, Haruhiko Kashima, Michael G. Kaplitt, Travis S. Tierney, Howard M. Eisenberg

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: Magnetic resonance imaging–guided focused ultrasound thalamotomy is approved by the U.S. Food and Drug Administration for treatment of essential tremor. Although this incisionless technology creates an ablative lesion, it potentially avoids serious complications of open stereotactic surgery. Objective: To determine the safety profile of magnetic resonance imaging–guided focused ultrasound unilateral thalamotomy for essential tremor, including frequency, and severity of adverse events, including serious adverse events. Methods: Analysis of safety data for magnetic resonance imaging–guided focused ultrasound thalamotomy (186 patients, five studies). Results: Procedure-related serious adverse events were very infrequent (1.6%), without intracerebral hemorrhages or infections. Adverse events were usually transient and were commonly rated as mild (79%) and rarely severe (1%). As previously reported, abnormalities in sensation and balance were the commonest thalamotomy-related adverse events. Conclusion: The overall safety profile of magnetic resonance imaging–guided focused ultrasound thalamotomy supports its role as a new option for patients with medically refractory essential tremor.

Original languageEnglish
Pages (from-to)843-847
Number of pages5
JournalMovement Disorders
Volume33
Issue number5
DOIs
Publication statusPublished - 2018 May

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Essential Tremor
Magnetic Resonance Spectroscopy
Safety
Cerebral Hemorrhage
United States Food and Drug Administration
Technology
Infection

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Fishman, P. S., Elias, W. J., Ghanouni, P., Gwinn, R., Lipsman, N., Schwartz, M., ... Eisenberg, H. M. (2018). Neurological adverse event profile of magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor. Movement Disorders, 33(5), 843-847. https://doi.org/10.1002/mds.27401
Fishman, Paul S. ; Elias, W. Jeffrey ; Ghanouni, Pejman ; Gwinn, Ryder ; Lipsman, Nir ; Schwartz, Michael ; Chang, Jin W. ; Taira, Takaomi ; Krishna, Vibhor ; Rezai, Ali ; Yamada, Kazumichi ; Igase, Keiji ; Cosgrove, Rees ; Kashima, Haruhiko ; Kaplitt, Michael G. ; Tierney, Travis S. ; Eisenberg, Howard M. / Neurological adverse event profile of magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor. In: Movement Disorders. 2018 ; Vol. 33, No. 5. pp. 843-847.
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abstract = "Background: Magnetic resonance imaging–guided focused ultrasound thalamotomy is approved by the U.S. Food and Drug Administration for treatment of essential tremor. Although this incisionless technology creates an ablative lesion, it potentially avoids serious complications of open stereotactic surgery. Objective: To determine the safety profile of magnetic resonance imaging–guided focused ultrasound unilateral thalamotomy for essential tremor, including frequency, and severity of adverse events, including serious adverse events. Methods: Analysis of safety data for magnetic resonance imaging–guided focused ultrasound thalamotomy (186 patients, five studies). Results: Procedure-related serious adverse events were very infrequent (1.6{\%}), without intracerebral hemorrhages or infections. Adverse events were usually transient and were commonly rated as mild (79{\%}) and rarely severe (1{\%}). As previously reported, abnormalities in sensation and balance were the commonest thalamotomy-related adverse events. Conclusion: The overall safety profile of magnetic resonance imaging–guided focused ultrasound thalamotomy supports its role as a new option for patients with medically refractory essential tremor.",
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Fishman, PS, Elias, WJ, Ghanouni, P, Gwinn, R, Lipsman, N, Schwartz, M, Chang, JW, Taira, T, Krishna, V, Rezai, A, Yamada, K, Igase, K, Cosgrove, R, Kashima, H, Kaplitt, MG, Tierney, TS & Eisenberg, HM 2018, 'Neurological adverse event profile of magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor', Movement Disorders, vol. 33, no. 5, pp. 843-847. https://doi.org/10.1002/mds.27401

Neurological adverse event profile of magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor. / Fishman, Paul S.; Elias, W. Jeffrey; Ghanouni, Pejman; Gwinn, Ryder; Lipsman, Nir; Schwartz, Michael; Chang, Jin W.; Taira, Takaomi; Krishna, Vibhor; Rezai, Ali; Yamada, Kazumichi; Igase, Keiji; Cosgrove, Rees; Kashima, Haruhiko; Kaplitt, Michael G.; Tierney, Travis S.; Eisenberg, Howard M.

In: Movement Disorders, Vol. 33, No. 5, 05.2018, p. 843-847.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neurological adverse event profile of magnetic resonance imaging–guided focused ultrasound thalamotomy for essential tremor

AU - Fishman, Paul S.

AU - Elias, W. Jeffrey

AU - Ghanouni, Pejman

AU - Gwinn, Ryder

AU - Lipsman, Nir

AU - Schwartz, Michael

AU - Chang, Jin W.

AU - Taira, Takaomi

AU - Krishna, Vibhor

AU - Rezai, Ali

AU - Yamada, Kazumichi

AU - Igase, Keiji

AU - Cosgrove, Rees

AU - Kashima, Haruhiko

AU - Kaplitt, Michael G.

AU - Tierney, Travis S.

AU - Eisenberg, Howard M.

PY - 2018/5

Y1 - 2018/5

N2 - Background: Magnetic resonance imaging–guided focused ultrasound thalamotomy is approved by the U.S. Food and Drug Administration for treatment of essential tremor. Although this incisionless technology creates an ablative lesion, it potentially avoids serious complications of open stereotactic surgery. Objective: To determine the safety profile of magnetic resonance imaging–guided focused ultrasound unilateral thalamotomy for essential tremor, including frequency, and severity of adverse events, including serious adverse events. Methods: Analysis of safety data for magnetic resonance imaging–guided focused ultrasound thalamotomy (186 patients, five studies). Results: Procedure-related serious adverse events were very infrequent (1.6%), without intracerebral hemorrhages or infections. Adverse events were usually transient and were commonly rated as mild (79%) and rarely severe (1%). As previously reported, abnormalities in sensation and balance were the commonest thalamotomy-related adverse events. Conclusion: The overall safety profile of magnetic resonance imaging–guided focused ultrasound thalamotomy supports its role as a new option for patients with medically refractory essential tremor.

AB - Background: Magnetic resonance imaging–guided focused ultrasound thalamotomy is approved by the U.S. Food and Drug Administration for treatment of essential tremor. Although this incisionless technology creates an ablative lesion, it potentially avoids serious complications of open stereotactic surgery. Objective: To determine the safety profile of magnetic resonance imaging–guided focused ultrasound unilateral thalamotomy for essential tremor, including frequency, and severity of adverse events, including serious adverse events. Methods: Analysis of safety data for magnetic resonance imaging–guided focused ultrasound thalamotomy (186 patients, five studies). Results: Procedure-related serious adverse events were very infrequent (1.6%), without intracerebral hemorrhages or infections. Adverse events were usually transient and were commonly rated as mild (79%) and rarely severe (1%). As previously reported, abnormalities in sensation and balance were the commonest thalamotomy-related adverse events. Conclusion: The overall safety profile of magnetic resonance imaging–guided focused ultrasound thalamotomy supports its role as a new option for patients with medically refractory essential tremor.

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