Neurophysiologic Correlates of Sonication Treatment in Patients with Essential Tremor

Jin Woo Chang, Byoung Kyong Min, Bong Soo Kim, Won Seok Chang, Yong Ho Lee

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13 Citations (Scopus)


Transcranial magnetic resonance imaging-guided high-intensity focused ultrasound (MRgHIFU) is gaining attention as a potent substitute for surgical intervention in the treatment of neurologic disorders. To discern the neurophysiologic correlates of its therapeutic effects, we applied MRgHIFU to an intractable neurologic disorder, essential tremor, while measuring magnetoencephalogram mu rhythms from the motor cortex. Focused ultrasound sonication destroyed tissues by focusing a high-energy beam on the ventralis intermedius nucleus of the thalamus. The post-treatment effectiveness was also evaluated using the clinical rating scale for tremors. Thalamic MRgHIFU had substantial therapeutic effects on patients, based on MRgHIFU-mediated improvements in movement control and significant changes in brain mu rhythms. Ultrasonic thalamotomy may reduce hyper-excitable activity in the motor cortex, resulting in normalized behavioral activity after sonication treatment. Thus, non-invasive and spatially accurate MRgHIFU technology can serve as a potent therapeutic tool with broad clinical applications.

Original languageEnglish
Pages (from-to)124-131
Number of pages8
JournalUltrasound in Medicine and Biology
Issue number1
Publication statusPublished - 2015 Jan 1

Bibliographical note

Funding Information:
This work was supported by grants awarded by the Industrial Source Technology Development Program (Grant 10033812) of the Ministry of Knowledge Economy, and the Basic Science Research Program (Grant 2012R1A1A1038358), and the Global Frontier R&D Program on Human-Centered Interaction for Coexistence (Grant 2012M3A6A3056103) of the Ministry of Education, Science, and Technology through the National Research Foundation of Korea. This work was also supported by a research grant from InSightec, Ltd . (Haifa, Israel) for clinical tests using the transcranial MRgHIFU.

Publisher Copyright:
© 2015 World Federation for Ultrasound in Medicine & Biology.

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Biophysics
  • Acoustics and Ultrasonics


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