Neurophysiologic Correlates of Sonication Treatment in Patients with Essential Tremor

Jin Woo Chang; Byoung Kyong Min; Bong Soo Kim; Won Seok Chang; Yong Ho Lee

doi:10.1016/j.ultrasmedbio.2014.08.008

Neurophysiologic Correlates of Sonication Treatment in Patients with Essential Tremor

Jin Woo Chang, Byoung Kyong Min, Bong Soo Kim, Won Seok Chang, Yong Ho Lee

Department of Neurosurgery

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

Transcranial magnetic resonance imaging-guided high-intensity focused ultrasound (MRgHIFU) is gaining attention as a potent substitute for surgical intervention in the treatment of neurologic disorders. To discern the neurophysiologic correlates of its therapeutic effects, we applied MRgHIFU to an intractable neurologic disorder, essential tremor, while measuring magnetoencephalogram mu rhythms from the motor cortex. Focused ultrasound sonication destroyed tissues by focusing a high-energy beam on the ventralis intermedius nucleus of the thalamus. The post-treatment effectiveness was also evaluated using the clinical rating scale for tremors. Thalamic MRgHIFU had substantial therapeutic effects on patients, based on MRgHIFU-mediated improvements in movement control and significant changes in brain mu rhythms. Ultrasonic thalamotomy may reduce hyper-excitable activity in the motor cortex, resulting in normalized behavioral activity after sonication treatment. Thus, non-invasive and spatially accurate MRgHIFU technology can serve as a potent therapeutic tool with broad clinical applications.

Original language	English
Pages (from-to)	124-131
Number of pages	8
Journal	Ultrasound in Medicine and Biology
Volume	41
Issue number	1
DOIs	https://doi.org/10.1016/j.ultrasmedbio.2014.08.008
Publication status	Published - 2015 Jan 1

Bibliographical note

Funding Information:
This work was supported by grants awarded by the Industrial Source Technology Development Program (Grant 10033812) of the Ministry of Knowledge Economy, and the Basic Science Research Program (Grant 2012R1A1A1038358), and the Global Frontier R&D Program on Human-Centered Interaction for Coexistence (Grant 2012M3A6A3056103) of the Ministry of Education, Science, and Technology through the National Research Foundation of Korea. This work was also supported by a research grant from InSightec, Ltd . (Haifa, Israel) for clinical tests using the transcranial MRgHIFU.

Publisher Copyright:
© 2015 World Federation for Ultrasound in Medicine & Biology.

All Science Journal Classification (ASJC) codes

Radiological and Ultrasound Technology
Biophysics
Acoustics and Ultrasonics

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10.1016/j.ultrasmedbio.2014.08.008

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title = "Neurophysiologic Correlates of Sonication Treatment in Patients with Essential Tremor",

abstract = "Transcranial magnetic resonance imaging-guided high-intensity focused ultrasound (MRgHIFU) is gaining attention as a potent substitute for surgical intervention in the treatment of neurologic disorders. To discern the neurophysiologic correlates of its therapeutic effects, we applied MRgHIFU to an intractable neurologic disorder, essential tremor, while measuring magnetoencephalogram mu rhythms from the motor cortex. Focused ultrasound sonication destroyed tissues by focusing a high-energy beam on the ventralis intermedius nucleus of the thalamus. The post-treatment effectiveness was also evaluated using the clinical rating scale for tremors. Thalamic MRgHIFU had substantial therapeutic effects on patients, based on MRgHIFU-mediated improvements in movement control and significant changes in brain mu rhythms. Ultrasonic thalamotomy may reduce hyper-excitable activity in the motor cortex, resulting in normalized behavioral activity after sonication treatment. Thus, non-invasive and spatially accurate MRgHIFU technology can serve as a potent therapeutic tool with broad clinical applications.",

author = "Chang, {Jin Woo} and Min, {Byoung Kyong} and Kim, {Bong Soo} and Chang, {Won Seok} and Lee, {Yong Ho}",

note = "Funding Information: This work was supported by grants awarded by the Industrial Source Technology Development Program (Grant 10033812) of the Ministry of Knowledge Economy, and the Basic Science Research Program (Grant 2012R1A1A1038358), and the Global Frontier R&D Program on Human-Centered Interaction for Coexistence (Grant 2012M3A6A3056103) of the Ministry of Education, Science, and Technology through the National Research Foundation of Korea. This work was also supported by a research grant from InSightec, Ltd . (Haifa, Israel) for clinical tests using the transcranial MRgHIFU. Publisher Copyright: {\textcopyright} 2015 World Federation for Ultrasound in Medicine & Biology.",

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N2 - Transcranial magnetic resonance imaging-guided high-intensity focused ultrasound (MRgHIFU) is gaining attention as a potent substitute for surgical intervention in the treatment of neurologic disorders. To discern the neurophysiologic correlates of its therapeutic effects, we applied MRgHIFU to an intractable neurologic disorder, essential tremor, while measuring magnetoencephalogram mu rhythms from the motor cortex. Focused ultrasound sonication destroyed tissues by focusing a high-energy beam on the ventralis intermedius nucleus of the thalamus. The post-treatment effectiveness was also evaluated using the clinical rating scale for tremors. Thalamic MRgHIFU had substantial therapeutic effects on patients, based on MRgHIFU-mediated improvements in movement control and significant changes in brain mu rhythms. Ultrasonic thalamotomy may reduce hyper-excitable activity in the motor cortex, resulting in normalized behavioral activity after sonication treatment. Thus, non-invasive and spatially accurate MRgHIFU technology can serve as a potent therapeutic tool with broad clinical applications.

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Neurophysiologic Correlates of Sonication Treatment in Patients with Essential Tremor

Abstract

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