Neuroprotective and anti-neuroinflammatory effects of ethanolic extract from leaves and stems of Aster glehni

Mi Kyung Lim, Soyeon Lee, Ju Yeon Kim, Jeongho Jeong, Eun Hye Han, Sang Ho Lee, Jong Hoon Ryu, Jinu Lee

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)


Aster glehni Fr. Schm. has been reported ameliorating effects on cognitive dysfunction. However, the molecular mechanisms underlying neurodegenerative diseases such as Alzheimer's disease (AD) are poorly understood. Herein, we examined whether the ethanolic extract from leaves and stems of Aster glehni Fr. Schm. (EAG) could have biological effects for therapy-related AD. EAG exerted the neuroprotective effects in SH-SY5Y neuroblastoma cells through extracellular signal-regulated kinase (ERK)/cAMP response element-binding protein (CREB)/brain-derived neurotrophic factor (BDNF) pathway. In addition, EAG suppressed expressions of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) and productions of nitric oxide (NO), and pro-inflammatory cytokines by blocking nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) pathway in lipopolysaccharide (LPS)-stimulated BV-2 microglial cells. This study also investigated that EAG possessed anti-neuroinflammatory effects in scopolamine-induced mice. Taken together, EAG and its caffeoylquinic acid could have anti-neurodegenerative properties derived from its ability to induce neuroprotection and anti-neuroinflammation.

Original languageEnglish
Article number104400
JournalJournal of Functional Foods
Publication statusPublished - 2021 Apr

Bibliographical note

Funding Information:
This work was supported by Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry and Fisheries (IPET) through High Value-added Food Technology Development Program, funded by Ministry of Agriculture, Food and Rural Affairs (MAFRA) (117077-03).

Publisher Copyright:
© 2021 The Author(s)

All Science Journal Classification (ASJC) codes

  • Food Science
  • Medicine (miscellaneous)
  • Nutrition and Dietetics


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