Neuroprotective Effect of a New Synthetic Aspirin-decursinol Adduct in Experimental Animal Models of Ischemic Stroke

Bing Chun Yan, Joon Ha Park, Bich Na Shin, Ji Hyeon Ahn, In Hye Kim, Jae Chul Lee, Ki Yeon Yoo, In Koo Hwang, Jung Hoon Choi, Jeong Ho Park, Yun Lyul Lee, Hong Won Suh, Jong Gab Jun, Young Guen Kwon, Young Myeong Kim, Seung Hae Kwon, Song Her, Jin Su Kim, Byung Hwa Hyun, Chul Kyu KimJun Hwi Cho, Choong Hyun Lee, Moo Ho Won

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Stroke is the second leading cause of death. Experimental animal models of cerebral ischemia are widely used for researching mechanisms of ischemic damage and developing new drugs for the prevention and treatment of stroke. The present study aimed to comparatively investigate neuroprotective effects of aspirin (ASA), decursinol (DA) and new synthetic aspirin-decursinol adduct (ASA-DA) against transient focal and global cerebral ischemic damage. We found that treatment with 20 mg/kg, not 10 mg/kg, ASA-DA protected against ischemia-induced neuronal death after transient focal and global ischemic damage, and its neuroprotective effect was much better than that of ASA or DA alone. In addition, 20 mg/kg ASA-DA treatment reduced the ischemia-induced gliosis and maintained antioxidants levels in the corresponding injury regions. In brief, ASA-DA, a new synthetic drug, dramatically protected neurons from ischemic damage, and neuroprotective effects of ASA-DA may be closely related to the attenuation of ischemia-induced gliosis and maintenance of antioxidants.

Original languageEnglish
Article numbere74886
JournalPloS one
Volume8
Issue number9
DOIs
Publication statusPublished - 2013 Sep 20

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neuroprotective effect
aspirin
Neuroprotective Agents
stroke
Aspirin
laboratory animals
Animals
Animal Models
animal models
Stroke
ischemia
Gliosis
Ischemia
Antioxidants
death
antioxidants
new drugs
Brain Ischemia
Pharmaceutical Preparations
Neurons

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Yan, B. C., Park, J. H., Shin, B. N., Ahn, J. H., Kim, I. H., Lee, J. C., ... Won, M. H. (2013). Neuroprotective Effect of a New Synthetic Aspirin-decursinol Adduct in Experimental Animal Models of Ischemic Stroke. PloS one, 8(9), [e74886]. https://doi.org/10.1371/journal.pone.0074886
Yan, Bing Chun ; Park, Joon Ha ; Shin, Bich Na ; Ahn, Ji Hyeon ; Kim, In Hye ; Lee, Jae Chul ; Yoo, Ki Yeon ; Hwang, In Koo ; Choi, Jung Hoon ; Park, Jeong Ho ; Lee, Yun Lyul ; Suh, Hong Won ; Jun, Jong Gab ; Kwon, Young Guen ; Kim, Young Myeong ; Kwon, Seung Hae ; Her, Song ; Kim, Jin Su ; Hyun, Byung Hwa ; Kim, Chul Kyu ; Cho, Jun Hwi ; Lee, Choong Hyun ; Won, Moo Ho. / Neuroprotective Effect of a New Synthetic Aspirin-decursinol Adduct in Experimental Animal Models of Ischemic Stroke. In: PloS one. 2013 ; Vol. 8, No. 9.
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abstract = "Stroke is the second leading cause of death. Experimental animal models of cerebral ischemia are widely used for researching mechanisms of ischemic damage and developing new drugs for the prevention and treatment of stroke. The present study aimed to comparatively investigate neuroprotective effects of aspirin (ASA), decursinol (DA) and new synthetic aspirin-decursinol adduct (ASA-DA) against transient focal and global cerebral ischemic damage. We found that treatment with 20 mg/kg, not 10 mg/kg, ASA-DA protected against ischemia-induced neuronal death after transient focal and global ischemic damage, and its neuroprotective effect was much better than that of ASA or DA alone. In addition, 20 mg/kg ASA-DA treatment reduced the ischemia-induced gliosis and maintained antioxidants levels in the corresponding injury regions. In brief, ASA-DA, a new synthetic drug, dramatically protected neurons from ischemic damage, and neuroprotective effects of ASA-DA may be closely related to the attenuation of ischemia-induced gliosis and maintenance of antioxidants.",
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Yan, BC, Park, JH, Shin, BN, Ahn, JH, Kim, IH, Lee, JC, Yoo, KY, Hwang, IK, Choi, JH, Park, JH, Lee, YL, Suh, HW, Jun, JG, Kwon, YG, Kim, YM, Kwon, SH, Her, S, Kim, JS, Hyun, BH, Kim, CK, Cho, JH, Lee, CH & Won, MH 2013, 'Neuroprotective Effect of a New Synthetic Aspirin-decursinol Adduct in Experimental Animal Models of Ischemic Stroke', PloS one, vol. 8, no. 9, e74886. https://doi.org/10.1371/journal.pone.0074886

Neuroprotective Effect of a New Synthetic Aspirin-decursinol Adduct in Experimental Animal Models of Ischemic Stroke. / Yan, Bing Chun; Park, Joon Ha; Shin, Bich Na; Ahn, Ji Hyeon; Kim, In Hye; Lee, Jae Chul; Yoo, Ki Yeon; Hwang, In Koo; Choi, Jung Hoon; Park, Jeong Ho; Lee, Yun Lyul; Suh, Hong Won; Jun, Jong Gab; Kwon, Young Guen; Kim, Young Myeong; Kwon, Seung Hae; Her, Song; Kim, Jin Su; Hyun, Byung Hwa; Kim, Chul Kyu; Cho, Jun Hwi; Lee, Choong Hyun; Won, Moo Ho.

In: PloS one, Vol. 8, No. 9, e74886, 20.09.2013.

Research output: Contribution to journalArticle

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T1 - Neuroprotective Effect of a New Synthetic Aspirin-decursinol Adduct in Experimental Animal Models of Ischemic Stroke

AU - Yan, Bing Chun

AU - Park, Joon Ha

AU - Shin, Bich Na

AU - Ahn, Ji Hyeon

AU - Kim, In Hye

AU - Lee, Jae Chul

AU - Yoo, Ki Yeon

AU - Hwang, In Koo

AU - Choi, Jung Hoon

AU - Park, Jeong Ho

AU - Lee, Yun Lyul

AU - Suh, Hong Won

AU - Jun, Jong Gab

AU - Kwon, Young Guen

AU - Kim, Young Myeong

AU - Kwon, Seung Hae

AU - Her, Song

AU - Kim, Jin Su

AU - Hyun, Byung Hwa

AU - Kim, Chul Kyu

AU - Cho, Jun Hwi

AU - Lee, Choong Hyun

AU - Won, Moo Ho

PY - 2013/9/20

Y1 - 2013/9/20

N2 - Stroke is the second leading cause of death. Experimental animal models of cerebral ischemia are widely used for researching mechanisms of ischemic damage and developing new drugs for the prevention and treatment of stroke. The present study aimed to comparatively investigate neuroprotective effects of aspirin (ASA), decursinol (DA) and new synthetic aspirin-decursinol adduct (ASA-DA) against transient focal and global cerebral ischemic damage. We found that treatment with 20 mg/kg, not 10 mg/kg, ASA-DA protected against ischemia-induced neuronal death after transient focal and global ischemic damage, and its neuroprotective effect was much better than that of ASA or DA alone. In addition, 20 mg/kg ASA-DA treatment reduced the ischemia-induced gliosis and maintained antioxidants levels in the corresponding injury regions. In brief, ASA-DA, a new synthetic drug, dramatically protected neurons from ischemic damage, and neuroprotective effects of ASA-DA may be closely related to the attenuation of ischemia-induced gliosis and maintenance of antioxidants.

AB - Stroke is the second leading cause of death. Experimental animal models of cerebral ischemia are widely used for researching mechanisms of ischemic damage and developing new drugs for the prevention and treatment of stroke. The present study aimed to comparatively investigate neuroprotective effects of aspirin (ASA), decursinol (DA) and new synthetic aspirin-decursinol adduct (ASA-DA) against transient focal and global cerebral ischemic damage. We found that treatment with 20 mg/kg, not 10 mg/kg, ASA-DA protected against ischemia-induced neuronal death after transient focal and global ischemic damage, and its neuroprotective effect was much better than that of ASA or DA alone. In addition, 20 mg/kg ASA-DA treatment reduced the ischemia-induced gliosis and maintained antioxidants levels in the corresponding injury regions. In brief, ASA-DA, a new synthetic drug, dramatically protected neurons from ischemic damage, and neuroprotective effects of ASA-DA may be closely related to the attenuation of ischemia-induced gliosis and maintenance of antioxidants.

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