Neuroprotective Effect of a New Synthetic Aspirin-decursinol Adduct in Experimental Animal Models of Ischemic Stroke

Bing Chun Yan, Joon Ha Park, Bich Na Shin, Ji Hyeon Ahn, In Hye Kim, Jae Chul Lee, Ki Yeon Yoo, In Koo Hwang, Jung Hoon Choi, Jeong Ho Park, Yun Lyul Lee, Hong Won Suh, Jong Gab Jun, Young Guen Kwon, Young Myeong Kim, Seung Hae Kwon, Song Her, Jin Su Kim, Byung Hwa Hyun, Chul Kyu KimJun Hwi Cho, Choong Hyun Lee, Moo Ho Won

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29 Citations (Scopus)

Abstract

Stroke is the second leading cause of death. Experimental animal models of cerebral ischemia are widely used for researching mechanisms of ischemic damage and developing new drugs for the prevention and treatment of stroke. The present study aimed to comparatively investigate neuroprotective effects of aspirin (ASA), decursinol (DA) and new synthetic aspirin-decursinol adduct (ASA-DA) against transient focal and global cerebral ischemic damage. We found that treatment with 20 mg/kg, not 10 mg/kg, ASA-DA protected against ischemia-induced neuronal death after transient focal and global ischemic damage, and its neuroprotective effect was much better than that of ASA or DA alone. In addition, 20 mg/kg ASA-DA treatment reduced the ischemia-induced gliosis and maintained antioxidants levels in the corresponding injury regions. In brief, ASA-DA, a new synthetic drug, dramatically protected neurons from ischemic damage, and neuroprotective effects of ASA-DA may be closely related to the attenuation of ischemia-induced gliosis and maintenance of antioxidants.

Original languageEnglish
Article numbere74886
JournalPloS one
Volume8
Issue number9
DOIs
Publication statusPublished - 2013 Sep 20

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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    Yan, B. C., Park, J. H., Shin, B. N., Ahn, J. H., Kim, I. H., Lee, J. C., Yoo, K. Y., Hwang, I. K., Choi, J. H., Park, J. H., Lee, Y. L., Suh, H. W., Jun, J. G., Kwon, Y. G., Kim, Y. M., Kwon, S. H., Her, S., Kim, J. S., Hyun, B. H., ... Won, M. H. (2013). Neuroprotective Effect of a New Synthetic Aspirin-decursinol Adduct in Experimental Animal Models of Ischemic Stroke. PloS one, 8(9), [e74886]. https://doi.org/10.1371/journal.pone.0074886