Neuropsychiatric symptoms and striatal monoamine availability in early Parkinson’s disease without dementia

Yoon Sang Oh, Jean Hee Kim, Sang Won Yoo, Eo Jin Hwang, Chul Hyoung Lyoo, Kwang Soo Lee, Joong Seok Kim

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6 Citations (Scopus)


Background and objective: Neuropsychiatric symptoms are relatively common in Parkinson’s disease (PD). Many studies have revealed that striatal monoamine availability is associated with specific neuropsychiatric symptoms. This study was aimed to investigate the association between comprehensive neuropsychiatric symptoms and striatal monoamine availability in patients with early PD without dementia. Methods: A total of 156 newly diagnosed patients with PD without dementia were included. All patients’ mental and behavioral problems were assessed with the 12-item Neuropsychiatric Inventory (NPI). They underwent positron emission tomography (PET) with 18F-N-(3-fluoropropyl)-2beta-carbon ethoxy-3beta-(4-iodophenyl) nortropane and brain magnetic resonance imaging (MRI). Patients were divided into no neuropsychiatric symptoms and neuropsychiatric symptoms groups according to total NPI score. After normalizing the PET images to spatially normalized MRI, regional standardized uptake value ratios (SUVRs) with a volume of interest template were analyzed for the two groups. Results: Ninety-eight patients had more than one neuropsychiatric symptom. The SUVR of the thalamus in neuropsychiatric symptoms group was significantly lower than the SUVR in no neuropsychiatric symptoms group independent of age, sex, disease duration, or severity of motor symptoms. Conclusion: Patients with early PD who have neuropsychiatric symptoms had a lower monoamine availability in the thalamus than those with no neuropsychiatric symptoms. This finding suggests that decreased monoamine transporter availability in the thalamus may be an imaging biomarker of neuropsychiatric symptoms in patients with PD.

Original languageEnglish
Pages (from-to)711-718
Number of pages8
JournalNeurological Sciences
Issue number2
Publication statusPublished - 2021 Feb

Bibliographical note

Funding Information:
This research was supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT (NRF-2017R1D1A1B06028086 and NRF-2019R1G1A1099554), and by the financial support of the Catholic Medical Center Research Foundation made in the program year of 2019. The funder had no role in study design, data collection and analysis, the decision to publish or manuscript preparation.

Publisher Copyright:
© 2020, Fondazione Società Italiana di Neurologia.

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health


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