Neurotrophin-3-over-expressing mesenchymal stem cell transplantation improves functional recovery and axonal outgrowth in a rat model of spinal cord injury

Kyung Hee Lee, Jin Soo Oh, Yoon Ha, Bae Hwan Lee, William A. Pennant, Do Heum Yoon, Keung Nyun Kim

Research output: Contribution to journalArticle

Abstract

We investigated whether the transplantation of neurotrophin-3 gene transfected mesenchymal stem cells (NT-3-MSC) could promote hind limb functional recovery and axonal outgrowth in a model of spinal cord injury. We found that NT3-MSC transplantation in the contused spinal cord significantly improved hind limb function, axonal outgrowth, and MSC survival, suggesting that gene therapy combined with MSC treatment may represent a useful strategy for treatment of spinal cord injury.

Original languageEnglish
Pages (from-to)477-481
Number of pages5
JournalTissue Engineering and Regenerative Medicine
Volume8
Issue number5
Publication statusPublished - 2011 Oct 1

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Mesenchymal Stem Cell Transplantation
Neurotrophin 3
Stem cells
Spinal Cord Injuries
Rats
Extremities
Transplantation
Recovery
Contusions
Mesenchymal Stromal Cells
Genetic Therapy
Gene therapy
Spinal Cord
Therapeutics
Genes
Nerve Growth Factors

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Biomedical Engineering

Cite this

Lee, Kyung Hee ; Oh, Jin Soo ; Ha, Yoon ; Lee, Bae Hwan ; Pennant, William A. ; Yoon, Do Heum ; Kim, Keung Nyun. / Neurotrophin-3-over-expressing mesenchymal stem cell transplantation improves functional recovery and axonal outgrowth in a rat model of spinal cord injury. In: Tissue Engineering and Regenerative Medicine. 2011 ; Vol. 8, No. 5. pp. 477-481.
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Neurotrophin-3-over-expressing mesenchymal stem cell transplantation improves functional recovery and axonal outgrowth in a rat model of spinal cord injury. / Lee, Kyung Hee; Oh, Jin Soo; Ha, Yoon; Lee, Bae Hwan; Pennant, William A.; Yoon, Do Heum; Kim, Keung Nyun.

In: Tissue Engineering and Regenerative Medicine, Vol. 8, No. 5, 01.10.2011, p. 477-481.

Research output: Contribution to journalArticle

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