We investigated whether the transplantation of neurotrophin-3 gene transfected mesenchymal stem cells (NT-3-MSC) could promote hind limb functional recovery and axonal outgrowth in a model of spinal cord injury. We found that NT3-MSC transplantation in the contused spinal cord significantly improved hind limb function, axonal outgrowth, and MSC survival, suggesting that gene therapy combined with MSC treatment may represent a useful strategy for treatment of spinal cord injury.
|Number of pages||5|
|Journal||Tissue Engineering and Regenerative Medicine|
|Publication status||Published - 2011 Oct|
All Science Journal Classification (ASJC) codes
- Medicine (miscellaneous)
- Biomedical Engineering