TY - JOUR
T1 - Neutrophil extracellular traps (NETs) in autoimmune diseases
T2 - A comprehensive review
AU - Lee, Keum Hwa
AU - Kronbichler, Andreas
AU - Park, David Duck Young
AU - Park, Young Min
AU - Moon, Hanwool
AU - Kim, Hyungdo
AU - Choi, Jun Hyug
AU - Choi, Young Seo
AU - Shim, Songjoo
AU - Lyu, Il Suk
AU - Yun, Byung Hwan
AU - Han, Yeonseung
AU - Lee, Donghee
AU - Lee, Sang Yoon
AU - Yoo, Byung Hun
AU - Lee, Kyung Hwan
AU - Kim, Tai Lim
AU - Kim, Heonki
AU - Shim, Joo Sung
AU - Nam, Wonseok
AU - So, Heesung
AU - Choi, Soo Yeon
AU - Lee, Sangmok
AU - Shin, Jae Il
N1 - Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017/11
Y1 - 2017/11
N2 - Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. Studies suggest that an imbalance between “NETosis,” which is a process by which NETs are formed, and NET degradation may be associated with autoimmune diseases. Neutrophils, interleukin-8, ANCA and other inflammatory molecules are considered to play a key role in NET formation. Prolonged exposure to NETs-related cascades is associated with autoimmunity and increases the chance of systemic organ damage. In this review, we discuss the roles of various inflammatory molecules in relation to NETs. We also describe the role of NETs in the pathogenesis of autoimmune diseases and discuss the possibility of using targeted therapies directed to NETs and associated molecules to treat autoimmune diseases.
AB - Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. Studies suggest that an imbalance between “NETosis,” which is a process by which NETs are formed, and NET degradation may be associated with autoimmune diseases. Neutrophils, interleukin-8, ANCA and other inflammatory molecules are considered to play a key role in NET formation. Prolonged exposure to NETs-related cascades is associated with autoimmunity and increases the chance of systemic organ damage. In this review, we discuss the roles of various inflammatory molecules in relation to NETs. We also describe the role of NETs in the pathogenesis of autoimmune diseases and discuss the possibility of using targeted therapies directed to NETs and associated molecules to treat autoimmune diseases.
UR - http://www.scopus.com/inward/record.url?scp=85030761499&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85030761499&partnerID=8YFLogxK
U2 - 10.1016/j.autrev.2017.09.012
DO - 10.1016/j.autrev.2017.09.012
M3 - Review article
C2 - 28899799
AN - SCOPUS:85030761499
SN - 1568-9972
VL - 16
SP - 1160
EP - 1173
JO - Autoimmunity Reviews
JF - Autoimmunity Reviews
IS - 11
ER -