Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review

Keum Hwa Lee, Andreas Kronbichler, David Duck Young Park, Young Min Park, Hanwool Moon, Hyungdo Kim, Jun Hyug Choi, Young Seo Choi, Songjoo Shim, Il Suk Lyu, Byung Hwan Yun, Yeonseung Han, Donghee Lee, Sang Yoon Lee, Byung Hun Yoo, Kyung Hwan Lee, Tai Lim Kim, Heonki Kim, Joo Sung Shim, Wonseok NamHeesung So, Soo Yeon Choi, Sangmok Lee, Jae Il Shin

Research output: Contribution to journalReview article

84 Citations (Scopus)

Abstract

Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. Studies suggest that an imbalance between “NETosis,” which is a process by which NETs are formed, and NET degradation may be associated with autoimmune diseases. Neutrophils, interleukin-8, ANCA and other inflammatory molecules are considered to play a key role in NET formation. Prolonged exposure to NETs-related cascades is associated with autoimmunity and increases the chance of systemic organ damage. In this review, we discuss the roles of various inflammatory molecules in relation to NETs. We also describe the role of NETs in the pathogenesis of autoimmune diseases and discuss the possibility of using targeted therapies directed to NETs and associated molecules to treat autoimmune diseases.

Original languageEnglish
Pages (from-to)1160-1173
Number of pages14
JournalAutoimmunity Reviews
Volume16
Issue number11
DOIs
Publication statusPublished - 2017 Nov

Fingerprint

Autoimmune Diseases
Neutrophils
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Extracellular Traps
Antineutrophil Cytoplasmic Antibodies
Gout
Autoimmunity
Interleukin-8
Psoriasis
Systemic Lupus Erythematosus
Rheumatoid Arthritis
Atherosclerosis
Membranes
Infection
Neoplasms

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Lee, Keum Hwa ; Kronbichler, Andreas ; Park, David Duck Young ; Park, Young Min ; Moon, Hanwool ; Kim, Hyungdo ; Choi, Jun Hyug ; Choi, Young Seo ; Shim, Songjoo ; Lyu, Il Suk ; Yun, Byung Hwan ; Han, Yeonseung ; Lee, Donghee ; Lee, Sang Yoon ; Yoo, Byung Hun ; Lee, Kyung Hwan ; Kim, Tai Lim ; Kim, Heonki ; Shim, Joo Sung ; Nam, Wonseok ; So, Heesung ; Choi, Soo Yeon ; Lee, Sangmok ; Shin, Jae Il. / Neutrophil extracellular traps (NETs) in autoimmune diseases : A comprehensive review. In: Autoimmunity Reviews. 2017 ; Vol. 16, No. 11. pp. 1160-1173.
@article{0c03d74318dc4bceb63acda2af2104ea,
title = "Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review",
abstract = "Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. Studies suggest that an imbalance between “NETosis,” which is a process by which NETs are formed, and NET degradation may be associated with autoimmune diseases. Neutrophils, interleukin-8, ANCA and other inflammatory molecules are considered to play a key role in NET formation. Prolonged exposure to NETs-related cascades is associated with autoimmunity and increases the chance of systemic organ damage. In this review, we discuss the roles of various inflammatory molecules in relation to NETs. We also describe the role of NETs in the pathogenesis of autoimmune diseases and discuss the possibility of using targeted therapies directed to NETs and associated molecules to treat autoimmune diseases.",
author = "Lee, {Keum Hwa} and Andreas Kronbichler and Park, {David Duck Young} and Park, {Young Min} and Hanwool Moon and Hyungdo Kim and Choi, {Jun Hyug} and Choi, {Young Seo} and Songjoo Shim and Lyu, {Il Suk} and Yun, {Byung Hwan} and Yeonseung Han and Donghee Lee and Lee, {Sang Yoon} and Yoo, {Byung Hun} and Lee, {Kyung Hwan} and Kim, {Tai Lim} and Heonki Kim and Shim, {Joo Sung} and Wonseok Nam and Heesung So and Choi, {Soo Yeon} and Sangmok Lee and Shin, {Jae Il}",
year = "2017",
month = "11",
doi = "10.1016/j.autrev.2017.09.012",
language = "English",
volume = "16",
pages = "1160--1173",
journal = "Autoimmunity Reviews",
issn = "1568-9972",
publisher = "Elsevier",
number = "11",

}

Lee, KH, Kronbichler, A, Park, DDY, Park, YM, Moon, H, Kim, H, Choi, JH, Choi, YS, Shim, S, Lyu, IS, Yun, BH, Han, Y, Lee, D, Lee, SY, Yoo, BH, Lee, KH, Kim, TL, Kim, H, Shim, JS, Nam, W, So, H, Choi, SY, Lee, S & Shin, JI 2017, 'Neutrophil extracellular traps (NETs) in autoimmune diseases: A comprehensive review', Autoimmunity Reviews, vol. 16, no. 11, pp. 1160-1173. https://doi.org/10.1016/j.autrev.2017.09.012

Neutrophil extracellular traps (NETs) in autoimmune diseases : A comprehensive review. / Lee, Keum Hwa; Kronbichler, Andreas; Park, David Duck Young; Park, Young Min; Moon, Hanwool; Kim, Hyungdo; Choi, Jun Hyug; Choi, Young Seo; Shim, Songjoo; Lyu, Il Suk; Yun, Byung Hwan; Han, Yeonseung; Lee, Donghee; Lee, Sang Yoon; Yoo, Byung Hun; Lee, Kyung Hwan; Kim, Tai Lim; Kim, Heonki; Shim, Joo Sung; Nam, Wonseok; So, Heesung; Choi, Soo Yeon; Lee, Sangmok; Shin, Jae Il.

In: Autoimmunity Reviews, Vol. 16, No. 11, 11.2017, p. 1160-1173.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Neutrophil extracellular traps (NETs) in autoimmune diseases

T2 - A comprehensive review

AU - Lee, Keum Hwa

AU - Kronbichler, Andreas

AU - Park, David Duck Young

AU - Park, Young Min

AU - Moon, Hanwool

AU - Kim, Hyungdo

AU - Choi, Jun Hyug

AU - Choi, Young Seo

AU - Shim, Songjoo

AU - Lyu, Il Suk

AU - Yun, Byung Hwan

AU - Han, Yeonseung

AU - Lee, Donghee

AU - Lee, Sang Yoon

AU - Yoo, Byung Hun

AU - Lee, Kyung Hwan

AU - Kim, Tai Lim

AU - Kim, Heonki

AU - Shim, Joo Sung

AU - Nam, Wonseok

AU - So, Heesung

AU - Choi, Soo Yeon

AU - Lee, Sangmok

AU - Shin, Jae Il

PY - 2017/11

Y1 - 2017/11

N2 - Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. Studies suggest that an imbalance between “NETosis,” which is a process by which NETs are formed, and NET degradation may be associated with autoimmune diseases. Neutrophils, interleukin-8, ANCA and other inflammatory molecules are considered to play a key role in NET formation. Prolonged exposure to NETs-related cascades is associated with autoimmunity and increases the chance of systemic organ damage. In this review, we discuss the roles of various inflammatory molecules in relation to NETs. We also describe the role of NETs in the pathogenesis of autoimmune diseases and discuss the possibility of using targeted therapies directed to NETs and associated molecules to treat autoimmune diseases.

AB - Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. Studies suggest that an imbalance between “NETosis,” which is a process by which NETs are formed, and NET degradation may be associated with autoimmune diseases. Neutrophils, interleukin-8, ANCA and other inflammatory molecules are considered to play a key role in NET formation. Prolonged exposure to NETs-related cascades is associated with autoimmunity and increases the chance of systemic organ damage. In this review, we discuss the roles of various inflammatory molecules in relation to NETs. We also describe the role of NETs in the pathogenesis of autoimmune diseases and discuss the possibility of using targeted therapies directed to NETs and associated molecules to treat autoimmune diseases.

UR - http://www.scopus.com/inward/record.url?scp=85030761499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85030761499&partnerID=8YFLogxK

U2 - 10.1016/j.autrev.2017.09.012

DO - 10.1016/j.autrev.2017.09.012

M3 - Review article

C2 - 28899799

AN - SCOPUS:85030761499

VL - 16

SP - 1160

EP - 1173

JO - Autoimmunity Reviews

JF - Autoimmunity Reviews

SN - 1568-9972

IS - 11

ER -