Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio: Novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss

Young Joon Seo, Jun Hui Jeong, Jae Young Choi, In Seok Moon

Research output: Contribution to journalArticle

34 Citations (Scopus)

Abstract

Background. We aim to provide useful evidence about the association of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with idiopathic sudden sensorineural hearing loss (ISSNHL) and its possibility of emerging as a cheap, reliable, and independent prognostic marker of ISSNHL. Methods. 348 patients diagnosed with ISSNHL were included in our retrospective data analysis. Blood samples and the hearing assessments of the patients were carried out. Then, the patients were divided into 2 groups as "recovered" and "unrecovered" according to their response to the treatment. Results. Both mean NLR and PLR values of the ISSNHL patients were significantly higher than the control group (both P<0.001). The NLR value was 5.98±4.22 in the unrecovered group and 3.50±3.38 in the recovered group (P<0.001). After adjustment in a binary logistic regression model, only NLR value was associated with the recovery of ISSNHL (P=0.001). Discussion. We demonstrated for the first time that NLR and PLR values were significantly high in ISSNHL patients. Also the NLR level might be taken into account as a novel potential marker to predict the patients' prognosis in terms of recovery.

Original languageEnglish
Article number702807
JournalDisease markers
Volume2014
DOIs
Publication statusPublished - 2014

Fingerprint

Sudden Hearing Loss
Lymphocytes
Sensorineural Hearing Loss
Audition
Platelets
Neutrophils
Blood Platelets
Logistic Models
Social Adjustment
Recovery
Hearing
Logistics
Blood
Control Groups

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Genetics
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

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abstract = "Background. We aim to provide useful evidence about the association of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with idiopathic sudden sensorineural hearing loss (ISSNHL) and its possibility of emerging as a cheap, reliable, and independent prognostic marker of ISSNHL. Methods. 348 patients diagnosed with ISSNHL were included in our retrospective data analysis. Blood samples and the hearing assessments of the patients were carried out. Then, the patients were divided into 2 groups as {"}recovered{"} and {"}unrecovered{"} according to their response to the treatment. Results. Both mean NLR and PLR values of the ISSNHL patients were significantly higher than the control group (both P<0.001). The NLR value was 5.98±4.22 in the unrecovered group and 3.50±3.38 in the recovered group (P<0.001). After adjustment in a binary logistic regression model, only NLR value was associated with the recovery of ISSNHL (P=0.001). Discussion. We demonstrated for the first time that NLR and PLR values were significantly high in ISSNHL patients. Also the NLR level might be taken into account as a novel potential marker to predict the patients' prognosis in terms of recovery.",
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Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio : Novel markers for diagnosis and prognosis in patients with idiopathic sudden sensorineural hearing loss. / Seo, Young Joon; Jeong, Jun Hui; Choi, Jae Young; Moon, In Seok.

In: Disease markers, Vol. 2014, 702807, 2014.

Research output: Contribution to journalArticle

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AU - Moon, In Seok

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AB - Background. We aim to provide useful evidence about the association of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) with idiopathic sudden sensorineural hearing loss (ISSNHL) and its possibility of emerging as a cheap, reliable, and independent prognostic marker of ISSNHL. Methods. 348 patients diagnosed with ISSNHL were included in our retrospective data analysis. Blood samples and the hearing assessments of the patients were carried out. Then, the patients were divided into 2 groups as "recovered" and "unrecovered" according to their response to the treatment. Results. Both mean NLR and PLR values of the ISSNHL patients were significantly higher than the control group (both P<0.001). The NLR value was 5.98±4.22 in the unrecovered group and 3.50±3.38 in the recovered group (P<0.001). After adjustment in a binary logistic regression model, only NLR value was associated with the recovery of ISSNHL (P=0.001). Discussion. We demonstrated for the first time that NLR and PLR values were significantly high in ISSNHL patients. Also the NLR level might be taken into account as a novel potential marker to predict the patients' prognosis in terms of recovery.

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