Neutrophil to lymphocyte ratio at diagnosis can estimate vasculitis activity and poor prognosis in patients with ANCA-associated vasculitis: A retrospective study

Sung Soo Ahn, Seung Min Jung, Jason Jungsik Song, YongBeom Park, Sang Won Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Background: Neutrophil to lymphocyte ratio (NLR) was introduced to predict poor prognosis in various diseases, but not all variants of ANCA-associated vasculitis (AAV). In this study, we aimed to investigate whether NLR at diagnosis can estimate vasculitis activity at diagnosis and poor prognosis during follow-up in patients with AAV. Methods: We retrospectively reviewed the medical records of 160 patients with AAV. We collected clinical and laboratory data at diagnosis and obtained remission and death as poor prognosis. We stratified AAV patients into three groups according to tertile and defined the lower limit of each highest tertile as the optimal cut-off (5.9 for NLR and 15.0 of Birmingham vasculitis activity score [BVAS] for severe AAV). Results: The mean age at diagnosis was 55.2 years and 48 patients were men. In the univariable linear regression analysis, BVAS was negatively correlated with lymphocyte count and positively correlated with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and NLR. In the multivariable linear regression analyses of ESR and CRP with either lymphocyte count or NLR, lymphocyte count (β = - 0.160) and NLR (β = 0.169) were associated with BVAS. Patients having NLR ≥ 5.9 exhibited severe AAV more frequently than those having NLR < 5.9 at diagnosis (relative 2.189, P = 0.023). Patients having NLR ≥ 5.9 exhibited a higher frequency of AAV relapse, but not death, than those having NLR < 5.9 (P = 0.016). Conclusions: NLR at diagnosis can estimate vasculitis activity at diagnosis and predict relapse during follow-up in patients with AAV.

Original languageEnglish
Article number187
JournalBMC Nephrology
Volume19
Issue number1
DOIs
Publication statusPublished - 2018 Jul 31

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Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis
Vasculitis
Neutrophils
Retrospective Studies
Lymphocytes
Lymphocyte Count
Blood Sedimentation
C-Reactive Protein
Linear Models
Regression Analysis
Recurrence
Medical Records

All Science Journal Classification (ASJC) codes

  • Nephrology

Cite this

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title = "Neutrophil to lymphocyte ratio at diagnosis can estimate vasculitis activity and poor prognosis in patients with ANCA-associated vasculitis: A retrospective study",
abstract = "Background: Neutrophil to lymphocyte ratio (NLR) was introduced to predict poor prognosis in various diseases, but not all variants of ANCA-associated vasculitis (AAV). In this study, we aimed to investigate whether NLR at diagnosis can estimate vasculitis activity at diagnosis and poor prognosis during follow-up in patients with AAV. Methods: We retrospectively reviewed the medical records of 160 patients with AAV. We collected clinical and laboratory data at diagnosis and obtained remission and death as poor prognosis. We stratified AAV patients into three groups according to tertile and defined the lower limit of each highest tertile as the optimal cut-off (5.9 for NLR and 15.0 of Birmingham vasculitis activity score [BVAS] for severe AAV). Results: The mean age at diagnosis was 55.2 years and 48 patients were men. In the univariable linear regression analysis, BVAS was negatively correlated with lymphocyte count and positively correlated with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and NLR. In the multivariable linear regression analyses of ESR and CRP with either lymphocyte count or NLR, lymphocyte count (β = - 0.160) and NLR (β = 0.169) were associated with BVAS. Patients having NLR ≥ 5.9 exhibited severe AAV more frequently than those having NLR < 5.9 at diagnosis (relative 2.189, P = 0.023). Patients having NLR ≥ 5.9 exhibited a higher frequency of AAV relapse, but not death, than those having NLR < 5.9 (P = 0.016). Conclusions: NLR at diagnosis can estimate vasculitis activity at diagnosis and predict relapse during follow-up in patients with AAV.",
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Neutrophil to lymphocyte ratio at diagnosis can estimate vasculitis activity and poor prognosis in patients with ANCA-associated vasculitis : A retrospective study. / Ahn, Sung Soo; Jung, Seung Min; Song, Jason Jungsik; Park, YongBeom; Lee, Sang Won.

In: BMC Nephrology, Vol. 19, No. 1, 187, 31.07.2018.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neutrophil to lymphocyte ratio at diagnosis can estimate vasculitis activity and poor prognosis in patients with ANCA-associated vasculitis

T2 - A retrospective study

AU - Ahn, Sung Soo

AU - Jung, Seung Min

AU - Song, Jason Jungsik

AU - Park, YongBeom

AU - Lee, Sang Won

PY - 2018/7/31

Y1 - 2018/7/31

N2 - Background: Neutrophil to lymphocyte ratio (NLR) was introduced to predict poor prognosis in various diseases, but not all variants of ANCA-associated vasculitis (AAV). In this study, we aimed to investigate whether NLR at diagnosis can estimate vasculitis activity at diagnosis and poor prognosis during follow-up in patients with AAV. Methods: We retrospectively reviewed the medical records of 160 patients with AAV. We collected clinical and laboratory data at diagnosis and obtained remission and death as poor prognosis. We stratified AAV patients into three groups according to tertile and defined the lower limit of each highest tertile as the optimal cut-off (5.9 for NLR and 15.0 of Birmingham vasculitis activity score [BVAS] for severe AAV). Results: The mean age at diagnosis was 55.2 years and 48 patients were men. In the univariable linear regression analysis, BVAS was negatively correlated with lymphocyte count and positively correlated with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and NLR. In the multivariable linear regression analyses of ESR and CRP with either lymphocyte count or NLR, lymphocyte count (β = - 0.160) and NLR (β = 0.169) were associated with BVAS. Patients having NLR ≥ 5.9 exhibited severe AAV more frequently than those having NLR < 5.9 at diagnosis (relative 2.189, P = 0.023). Patients having NLR ≥ 5.9 exhibited a higher frequency of AAV relapse, but not death, than those having NLR < 5.9 (P = 0.016). Conclusions: NLR at diagnosis can estimate vasculitis activity at diagnosis and predict relapse during follow-up in patients with AAV.

AB - Background: Neutrophil to lymphocyte ratio (NLR) was introduced to predict poor prognosis in various diseases, but not all variants of ANCA-associated vasculitis (AAV). In this study, we aimed to investigate whether NLR at diagnosis can estimate vasculitis activity at diagnosis and poor prognosis during follow-up in patients with AAV. Methods: We retrospectively reviewed the medical records of 160 patients with AAV. We collected clinical and laboratory data at diagnosis and obtained remission and death as poor prognosis. We stratified AAV patients into three groups according to tertile and defined the lower limit of each highest tertile as the optimal cut-off (5.9 for NLR and 15.0 of Birmingham vasculitis activity score [BVAS] for severe AAV). Results: The mean age at diagnosis was 55.2 years and 48 patients were men. In the univariable linear regression analysis, BVAS was negatively correlated with lymphocyte count and positively correlated with erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and NLR. In the multivariable linear regression analyses of ESR and CRP with either lymphocyte count or NLR, lymphocyte count (β = - 0.160) and NLR (β = 0.169) were associated with BVAS. Patients having NLR ≥ 5.9 exhibited severe AAV more frequently than those having NLR < 5.9 at diagnosis (relative 2.189, P = 0.023). Patients having NLR ≥ 5.9 exhibited a higher frequency of AAV relapse, but not death, than those having NLR < 5.9 (P = 0.016). Conclusions: NLR at diagnosis can estimate vasculitis activity at diagnosis and predict relapse during follow-up in patients with AAV.

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U2 - 10.1186/s12882-018-0992-4

DO - 10.1186/s12882-018-0992-4

M3 - Article

C2 - 30064369

AN - SCOPUS:85051171445

VL - 19

JO - BMC Nephrology

JF - BMC Nephrology

SN - 1471-2369

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