New alkaloids and anti-inflammatory constituents from the leaves of Antidesma ghaesembilla

Phan Van Kiem, Le Canh Viet Cuong, Do Thi Trang, Nguyen Xuan Nhiem, Hoang Le Tuan Anh, Bui Huu Tai, Le Mai Huong, Chau Van Minh, Taek Hwan Lee, Sun Yeou Kim, Seung Hyun Kim

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Abstract

Using various chromatographic methods, two new alkaloids, antidesoic acids A (1) and B (2) along with fourteen known compounds (3-16) were isolated from the leaves of Antidesma ghaesembilla Gaertn. Their chemical structures were elucidated by physical and chemical methods. All the isolated compounds were evaluated for their inhibitory activity on LPS-stimulated nitric oxide (NO) production in BV2 cells and RAW 264.7 macrophages. Bisflavone 8 significantly inhibited LPSstimulated NO production in BV2 cells and RAW 264.7 macrophages with IC50 values of 5.4 and 8.0 μM, respectively. Compounds 1-3, 7, 10, 12, 14, and 16 showed moderate inhibitory activities with IC50 values ranging from 11.7 to 77.4 μM.

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalNatural Product Communications
Volume12
Issue number1
Publication statusPublished - 2017 Jan 1

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All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery
  • Plant Science
  • Complementary and alternative medicine

Cite this

Van Kiem, P., Cuong, L. C. V., Trang, D. T., Nhiem, N. X., Anh, H. L. T., Tai, B. H., Huong, L. M., Minh, C. V., Lee, T. H., Kim, S. Y., & Kim, S. H. (2017). New alkaloids and anti-inflammatory constituents from the leaves of Antidesma ghaesembilla. Natural Product Communications, 12(1), 11-14.