New cationic lipids for gene transfer with high efficiency and low toxicity: T-shape cholesterol ester derivatives

Yan Lee, Heebeom Koo, Yong Beom Lim, Youngeun Lee, Heejung Mo, Jong Sang Park

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

New degradable cationic ester lipids with 'T-shape' configurations were synthesized and tested for gene delivery carrier. Their transfection efficiency and toxicity were compared with commercially available cationic lipids, DOTMA, DOSPA, and DC-Chol. They showed efficient transfection activity and almost no toxicity on mammalian cell lines. Their ester bond degradation was monitored by 1H NMR.

Original languageEnglish
Pages (from-to)2637-2641
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number10
DOIs
Publication statusPublished - 2004 May 17

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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