New drug delivery for corneal neovascularization using polyion complex micelles

Tomohiko Usui, Kenji Sugisaki, Shiro Amano, Woo Dong Jang, Nobuhiro Nishiyama, Kazunori Kataoka

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Purpose: To introduce photodynamic therapy (PDT) for corneal neovascularization (NV) by polyion complex (PIC) micelles, a novel drug delivery system. Methods and Results: Development of specific drug delivery systems to corneal NV sites is an important part of next-generation photodynamic therapy. Nanocarriers consisting of PIC micelles bound by polyethylene glycol (PEG) shell exhibit good stability, high drug-loading capacity, and excellent potential for controlled drug release. Encapsulation of the photosensitizer dendrimer porphyrin (DP) into PIC micelles (DP-micelles) conveys adequate stability and increased photocytotoxicity without compromising photophysical properties of DP stability. We assessed the accumulation of DP-micelles and observed that the DP-micelles were incorporated into the corneal NV area. Conclusions: PIC micelles possess attractive features of selective accumulation at the corneal NV site. PDT using DP-micelles appears to be effective and safe for the treatment of corneal NV.

Original languageEnglish
Pages (from-to)S39-S42
JournalCornea
Volume24
Issue number8 SUPPL.
DOIs
Publication statusPublished - 2005 Nov

All Science Journal Classification (ASJC) codes

  • Ophthalmology

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    Usui, T., Sugisaki, K., Amano, S., Jang, W. D., Nishiyama, N., & Kataoka, K. (2005). New drug delivery for corneal neovascularization using polyion complex micelles. Cornea, 24(8 SUPPL.), S39-S42. https://doi.org/10.1097/01.ico.0000178738.29459.59