New drug delivery for corneal neovascularization using polyion complex micelles

Tomohiko Usui, Kenji Sugisaki, Shiro Amano, Woo Dong Jang, Nobuhiro Nishiyama, Kazunori Kataoka

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Purpose: To introduce photodynamic therapy (PDT) for corneal neovascularization (NV) by polyion complex (PIC) micelles, a novel drug delivery system. Methods and Results: Development of specific drug delivery systems to corneal NV sites is an important part of next-generation photodynamic therapy. Nanocarriers consisting of PIC micelles bound by polyethylene glycol (PEG) shell exhibit good stability, high drug-loading capacity, and excellent potential for controlled drug release. Encapsulation of the photosensitizer dendrimer porphyrin (DP) into PIC micelles (DP-micelles) conveys adequate stability and increased photocytotoxicity without compromising photophysical properties of DP stability. We assessed the accumulation of DP-micelles and observed that the DP-micelles were incorporated into the corneal NV area. Conclusions: PIC micelles possess attractive features of selective accumulation at the corneal NV site. PDT using DP-micelles appears to be effective and safe for the treatment of corneal NV.

Original languageEnglish
Pages (from-to)S39-S42
JournalCornea
Volume24
Issue number8 SUPPL.
Publication statusPublished - 2005 Nov 1

Fingerprint

Corneal Neovascularization
Micelles
Dendrimers
Porphyrins
Pharmaceutical Preparations
Photochemotherapy
Drug Delivery Systems
Drug Stability
Photosensitizing Agents

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Usui, T., Sugisaki, K., Amano, S., Jang, W. D., Nishiyama, N., & Kataoka, K. (2005). New drug delivery for corneal neovascularization using polyion complex micelles. Cornea, 24(8 SUPPL.), S39-S42.
Usui, Tomohiko ; Sugisaki, Kenji ; Amano, Shiro ; Jang, Woo Dong ; Nishiyama, Nobuhiro ; Kataoka, Kazunori. / New drug delivery for corneal neovascularization using polyion complex micelles. In: Cornea. 2005 ; Vol. 24, No. 8 SUPPL. pp. S39-S42.
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Usui, T, Sugisaki, K, Amano, S, Jang, WD, Nishiyama, N & Kataoka, K 2005, 'New drug delivery for corneal neovascularization using polyion complex micelles', Cornea, vol. 24, no. 8 SUPPL., pp. S39-S42.

New drug delivery for corneal neovascularization using polyion complex micelles. / Usui, Tomohiko; Sugisaki, Kenji; Amano, Shiro; Jang, Woo Dong; Nishiyama, Nobuhiro; Kataoka, Kazunori.

In: Cornea, Vol. 24, No. 8 SUPPL., 01.11.2005, p. S39-S42.

Research output: Contribution to journalArticle

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AU - Usui, Tomohiko

AU - Sugisaki, Kenji

AU - Amano, Shiro

AU - Jang, Woo Dong

AU - Nishiyama, Nobuhiro

AU - Kataoka, Kazunori

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N2 - Purpose: To introduce photodynamic therapy (PDT) for corneal neovascularization (NV) by polyion complex (PIC) micelles, a novel drug delivery system. Methods and Results: Development of specific drug delivery systems to corneal NV sites is an important part of next-generation photodynamic therapy. Nanocarriers consisting of PIC micelles bound by polyethylene glycol (PEG) shell exhibit good stability, high drug-loading capacity, and excellent potential for controlled drug release. Encapsulation of the photosensitizer dendrimer porphyrin (DP) into PIC micelles (DP-micelles) conveys adequate stability and increased photocytotoxicity without compromising photophysical properties of DP stability. We assessed the accumulation of DP-micelles and observed that the DP-micelles were incorporated into the corneal NV area. Conclusions: PIC micelles possess attractive features of selective accumulation at the corneal NV site. PDT using DP-micelles appears to be effective and safe for the treatment of corneal NV.

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Usui T, Sugisaki K, Amano S, Jang WD, Nishiyama N, Kataoka K. New drug delivery for corneal neovascularization using polyion complex micelles. Cornea. 2005 Nov 1;24(8 SUPPL.):S39-S42.