New index for categorising cardiac reentrant wave: In silico evaluation

E. B. Shim, S. B. Hong, K. M. Lim, C. H. Leem, C. H. Youn, H. N. Pak, Y. E. Earm, D. Noble

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Based on the similarity between a reentrant wave in cardiac tissue and a vortex in fluid dynamics, the authors hypothesised that a new non-dimensional index, like the Reynolds number in fluid dynamics, may play a critical role in categorising reentrant wave dynamics. Therefore the goal of the present study is to devise a new index to characterise electric wave conduction in cardiac tissue and examined whether this index can be used as a biomarker for categorising the reentrant wave pattern in cardiac tissue. Similar to the procedure used to derive the Reynolds number in fluid dynamics, the authors used a non-dimensionalisation technique to obtain the new index. Its usefulness was verified using a two-dimensional simulation model of electrical wave propagation in cardiac tissue. The simulation results showed that electrical waves in cardiac tissue move into an unstable region when the index exceeds a threshold value.

Original languageEnglish
Pages (from-to)317-323
Number of pages7
JournalIET Systems Biology
Volume5
Issue number5
DOIs
Publication statusPublished - 2011 Sep

All Science Journal Classification (ASJC) codes

  • Biotechnology
  • Modelling and Simulation
  • Molecular Biology
  • Genetics
  • Cell Biology

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