Metabolic syndrome (MetS) is increasing globally and is clinically significant due to its association with cardiovascular disease, type 2 diabetes and cancer. Although the pathogenesis of MetS has not been clearly elucidated, insulin resistance and chronic low-grade inflammation derived from central obesity are the most widely accepted as underlying pathophysiology. Accordingly, insulin resistance indices, adipokines and various inflammatory markers have been suggested as reliable biomarkers for MetS. Others, such as uric acid, alkaline phosphatase, γ-glutamyl transferase, are also known to positively correlate with MetS and could be diagnostically useful. In this review, we provide a comprehensive overview of MetS biomarkers and the development of a systematic approach to laboratory analysis.
|Title of host publication||Advances in Clinical Chemistry|
|Editors||Gregory S. Makowski, Gregory S. Makowski|
|Publisher||Academic Press Inc.|
|Number of pages||35|
|Publication status||Published - 2022 Jan|
|Name||Advances in Clinical Chemistry|
Bibliographical notePublisher Copyright:
© 2022 Elsevier Inc.
All Science Journal Classification (ASJC) codes
- Clinical Biochemistry