Background New-onset postoperative atrial fibrillation (POAF) is associated with poor short- and long-term outcomes after isolated coronary artery bypass graft (CABG). This study evaluated whether new-onset POAF is independently associated with long-term (>1 year) atrial fibrillation (AF) and mortality. Methods Among 1,171 consecutive patients who had undergone CABG, AF and mortality were compared between patients with POAF (POAF group, n = 244) and those without POAF (no-POAF group, n = 927) after propensity score matching. Results During the follow-up period of 41 ± 23 months (range 0-87 months), the POAF group had a higher incidence of total (20/927 [2.2%] vs 46/244 [18.9%], P <.001) and long-term AF recurrence (13/927 [1.4%] vs 25/244 [10.2%], P <.001). Even after propensity score matching, the POAF group still showed a higher incidence of total (7/244 [2.9%] vs 46/224 [18.9%], P <.001) and long-term AF recurrence (4/244 [1.6%] vs 25/224 [10.2%], P <.001). In addition, the POAF group had a lower cumulative survival free of long-term AF than the no-POAF group (P <.001). In competing risk regression, POAF was an independent predictor of long-term newly developed AF (hazard ratio 4.99, 95% CI 1.68-14.84, P =.004). Cumulative survival free of death was worse in patients with POAF (P =.01). Conclusions New-onset POAF was shown to be a predictor of long-term newly developed AF in CABG patients. The results of this study suggest that patients who develop POAF should undergo strict surveillance and routine screening for AF during follow-up after surgery.
Bibliographical noteFunding Information:
This study was supported in part by the Basic Science Research Program through the National Research Foundation of Korea, funded by the Ministry of Education, Science and Technology (2012-0007604, 2012-045367), and the Korean Healthcare Technology R&D Project, Ministry of Health & Welfare (A121668). No extramural funding was used to support this work. The authors are solely responsible for the design and conduct of this study, all study analyses, the drafting and editing of the manuscript, and its final contents.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine