New-onset atrial fibrillation predicts long-term newly developed atrial fibrillation after coronary artery bypass graft

Seung Hyun Lee, Dae Ryong Kang, Jae Sun Uhm, Jaemin Shim, Jung Hoon Sung, Jong Youn Kim, huinam pak, Moon Hyoung Lee, Boyoung Joung

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Abstract

Background New-onset postoperative atrial fibrillation (POAF) is associated with poor short- and long-term outcomes after isolated coronary artery bypass graft (CABG). This study evaluated whether new-onset POAF is independently associated with long-term (>1 year) atrial fibrillation (AF) and mortality. Methods Among 1,171 consecutive patients who had undergone CABG, AF and mortality were compared between patients with POAF (POAF group, n = 244) and those without POAF (no-POAF group, n = 927) after propensity score matching. Results During the follow-up period of 41 ± 23 months (range 0-87 months), the POAF group had a higher incidence of total (20/927 [2.2%] vs 46/244 [18.9%], P <.001) and long-term AF recurrence (13/927 [1.4%] vs 25/244 [10.2%], P <.001). Even after propensity score matching, the POAF group still showed a higher incidence of total (7/244 [2.9%] vs 46/224 [18.9%], P <.001) and long-term AF recurrence (4/244 [1.6%] vs 25/224 [10.2%], P <.001). In addition, the POAF group had a lower cumulative survival free of long-term AF than the no-POAF group (P <.001). In competing risk regression, POAF was an independent predictor of long-term newly developed AF (hazard ratio 4.99, 95% CI 1.68-14.84, P =.004). Cumulative survival free of death was worse in patients with POAF (P =.01). Conclusions New-onset POAF was shown to be a predictor of long-term newly developed AF in CABG patients. The results of this study suggest that patients who develop POAF should undergo strict surveillance and routine screening for AF during follow-up after surgery.

Original languageEnglish
JournalAmerican Heart Journal
Volume167
Issue number4
DOIs
Publication statusPublished - 2014 Jan 1

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Coronary Artery Bypass
Atrial Fibrillation
Transplants
Propensity Score
Recurrence
Survival
Mortality
Incidence

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Lee, Seung Hyun ; Kang, Dae Ryong ; Uhm, Jae Sun ; Shim, Jaemin ; Sung, Jung Hoon ; Kim, Jong Youn ; pak, huinam ; Lee, Moon Hyoung ; Joung, Boyoung. / New-onset atrial fibrillation predicts long-term newly developed atrial fibrillation after coronary artery bypass graft. In: American Heart Journal. 2014 ; Vol. 167, No. 4.
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title = "New-onset atrial fibrillation predicts long-term newly developed atrial fibrillation after coronary artery bypass graft",
abstract = "Background New-onset postoperative atrial fibrillation (POAF) is associated with poor short- and long-term outcomes after isolated coronary artery bypass graft (CABG). This study evaluated whether new-onset POAF is independently associated with long-term (>1 year) atrial fibrillation (AF) and mortality. Methods Among 1,171 consecutive patients who had undergone CABG, AF and mortality were compared between patients with POAF (POAF group, n = 244) and those without POAF (no-POAF group, n = 927) after propensity score matching. Results During the follow-up period of 41 ± 23 months (range 0-87 months), the POAF group had a higher incidence of total (20/927 [2.2{\%}] vs 46/244 [18.9{\%}], P <.001) and long-term AF recurrence (13/927 [1.4{\%}] vs 25/244 [10.2{\%}], P <.001). Even after propensity score matching, the POAF group still showed a higher incidence of total (7/244 [2.9{\%}] vs 46/224 [18.9{\%}], P <.001) and long-term AF recurrence (4/244 [1.6{\%}] vs 25/224 [10.2{\%}], P <.001). In addition, the POAF group had a lower cumulative survival free of long-term AF than the no-POAF group (P <.001). In competing risk regression, POAF was an independent predictor of long-term newly developed AF (hazard ratio 4.99, 95{\%} CI 1.68-14.84, P =.004). Cumulative survival free of death was worse in patients with POAF (P =.01). Conclusions New-onset POAF was shown to be a predictor of long-term newly developed AF in CABG patients. The results of this study suggest that patients who develop POAF should undergo strict surveillance and routine screening for AF during follow-up after surgery.",
author = "Lee, {Seung Hyun} and Kang, {Dae Ryong} and Uhm, {Jae Sun} and Jaemin Shim and Sung, {Jung Hoon} and Kim, {Jong Youn} and huinam pak and Lee, {Moon Hyoung} and Boyoung Joung",
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New-onset atrial fibrillation predicts long-term newly developed atrial fibrillation after coronary artery bypass graft. / Lee, Seung Hyun; Kang, Dae Ryong; Uhm, Jae Sun; Shim, Jaemin; Sung, Jung Hoon; Kim, Jong Youn; pak, huinam; Lee, Moon Hyoung; Joung, Boyoung.

In: American Heart Journal, Vol. 167, No. 4, 01.01.2014.

Research output: Contribution to journalArticle

TY - JOUR

T1 - New-onset atrial fibrillation predicts long-term newly developed atrial fibrillation after coronary artery bypass graft

AU - Lee, Seung Hyun

AU - Kang, Dae Ryong

AU - Uhm, Jae Sun

AU - Shim, Jaemin

AU - Sung, Jung Hoon

AU - Kim, Jong Youn

AU - pak, huinam

AU - Lee, Moon Hyoung

AU - Joung, Boyoung

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Background New-onset postoperative atrial fibrillation (POAF) is associated with poor short- and long-term outcomes after isolated coronary artery bypass graft (CABG). This study evaluated whether new-onset POAF is independently associated with long-term (>1 year) atrial fibrillation (AF) and mortality. Methods Among 1,171 consecutive patients who had undergone CABG, AF and mortality were compared between patients with POAF (POAF group, n = 244) and those without POAF (no-POAF group, n = 927) after propensity score matching. Results During the follow-up period of 41 ± 23 months (range 0-87 months), the POAF group had a higher incidence of total (20/927 [2.2%] vs 46/244 [18.9%], P <.001) and long-term AF recurrence (13/927 [1.4%] vs 25/244 [10.2%], P <.001). Even after propensity score matching, the POAF group still showed a higher incidence of total (7/244 [2.9%] vs 46/224 [18.9%], P <.001) and long-term AF recurrence (4/244 [1.6%] vs 25/224 [10.2%], P <.001). In addition, the POAF group had a lower cumulative survival free of long-term AF than the no-POAF group (P <.001). In competing risk regression, POAF was an independent predictor of long-term newly developed AF (hazard ratio 4.99, 95% CI 1.68-14.84, P =.004). Cumulative survival free of death was worse in patients with POAF (P =.01). Conclusions New-onset POAF was shown to be a predictor of long-term newly developed AF in CABG patients. The results of this study suggest that patients who develop POAF should undergo strict surveillance and routine screening for AF during follow-up after surgery.

AB - Background New-onset postoperative atrial fibrillation (POAF) is associated with poor short- and long-term outcomes after isolated coronary artery bypass graft (CABG). This study evaluated whether new-onset POAF is independently associated with long-term (>1 year) atrial fibrillation (AF) and mortality. Methods Among 1,171 consecutive patients who had undergone CABG, AF and mortality were compared between patients with POAF (POAF group, n = 244) and those without POAF (no-POAF group, n = 927) after propensity score matching. Results During the follow-up period of 41 ± 23 months (range 0-87 months), the POAF group had a higher incidence of total (20/927 [2.2%] vs 46/244 [18.9%], P <.001) and long-term AF recurrence (13/927 [1.4%] vs 25/244 [10.2%], P <.001). Even after propensity score matching, the POAF group still showed a higher incidence of total (7/244 [2.9%] vs 46/224 [18.9%], P <.001) and long-term AF recurrence (4/244 [1.6%] vs 25/224 [10.2%], P <.001). In addition, the POAF group had a lower cumulative survival free of long-term AF than the no-POAF group (P <.001). In competing risk regression, POAF was an independent predictor of long-term newly developed AF (hazard ratio 4.99, 95% CI 1.68-14.84, P =.004). Cumulative survival free of death was worse in patients with POAF (P =.01). Conclusions New-onset POAF was shown to be a predictor of long-term newly developed AF in CABG patients. The results of this study suggest that patients who develop POAF should undergo strict surveillance and routine screening for AF during follow-up after surgery.

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