New schiartane-type triterpene from Kadsura heteroclita and their cytotoxic activities

Pham Thi Hong Minh, Do Tien Lam, Nguyen Quyet Tien, Nguyen Ngoc Tuan, Vu Phuong Nhung, Nong Van Hai, Phan Van Kiem, Nguyen Xuan Nhiem, Chau Van Minh, Park Seon Ju, Kim Seung Hyun

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5 Citations (Scopus)

Abstract

One new schiartane-type triterpene, heteroclitalactone N (1), and four known compounds (2-5), seco-coccinic acid F, dihydroguaiaretic acid, schizanrin F, and kadsuralignan B were isolated from the stems of Kadsura heteroclita. Their structures were determined by the combination of spectroscopic and chemical methods, including 1D-, 2D-NMR, and CD spectra as well as by comparing with the NMR data reported in the literature. The cytotoxic activities of all isolated compounds were evaluated on three human cancer cell lines. Compound 3 exhibited moderate to weak cytotoxic activities on three human cancer cell lines, OVCAR, HT-29, and A-549, with IC50 values ranging from 16.2 to 36.4 μM.

Original languageEnglish
Pages (from-to)373-374
Number of pages2
JournalNatural product communications
Volume9
Issue number3
DOIs
Publication statusPublished - 2014

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Plant Science
  • Drug Discovery
  • Complementary and alternative medicine

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    Minh, P. T. H., Lam, D. T., Tien, N. Q., Tuan, N. N., Nhung, V. P., Hai, N. V., Kiem, P. V., Nhiem, N. X., Minh, C. V., Ju, P. S., & Hyun, K. S. (2014). New schiartane-type triterpene from Kadsura heteroclita and their cytotoxic activities. Natural product communications, 9(3), 373-374. https://doi.org/10.1177/1934578x1400900324