New secoisolariciresinol derivatives from lindera obtusiloba stems and their neuroprotective activities

Ki Yong Lee; Soon Han Kim; Eun Ju Jeong; Jung Hyun Park; Seung Hyun Kim; Young Choong Kim; Sang Hyun Sung

doi:10.1055/s-0029-1186053

New secoisolariciresinol derivatives from lindera obtusiloba stems and their neuroprotective activities

Ki Yong Lee, Soon Han Kim, Eun Ju Jeong, Jung Hyun Park, Seung Hyun Kim, Young Choong Kim, Sang Hyun Sung

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9-O-di-(E)-feruloyl-meso- 5,5-dimethoxysecoisolariciresinol (1) and 9,9-O-di-(E)-sinapinoyl-meso-5,5- dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L.obtusiloba stems. Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.

Original language	English
Pages (from-to)	294-297
Number of pages	4
Journal	Planta Medica
Volume	76
Issue number	3
DOIs	https://doi.org/10.1055/s-0029-1186053
Publication status	Published - 2010

All Science Journal Classification (ASJC) codes

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

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title = "New secoisolariciresinol derivatives from lindera obtusiloba stems and their neuroprotective activities",

abstract = "A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9-O-di-(E)-feruloyl-meso- 5,5-dimethoxysecoisolariciresinol (1) and 9,9-O-di-(E)-sinapinoyl-meso-5,5- dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L.obtusiloba stems. Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.",

author = "Lee, {Ki Yong} and Kim, {Soon Han} and Jeong, {Eun Ju} and Park, {Jung Hyun} and Kim, {Seung Hyun} and Kim, {Young Choong} and Sung, {Sang Hyun}",

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T1 - New secoisolariciresinol derivatives from lindera obtusiloba stems and their neuroprotective activities

AU - Lee, Ki Yong

AU - Kim, Soon Han

AU - Jeong, Eun Ju

AU - Park, Jung Hyun

AU - Kim, Seung Hyun

AU - Kim, Young Choong

AU - Sung, Sang Hyun

PY - 2010

Y1 - 2010

N2 - A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9-O-di-(E)-feruloyl-meso- 5,5-dimethoxysecoisolariciresinol (1) and 9,9-O-di-(E)-sinapinoyl-meso-5,5- dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L.obtusiloba stems. Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.

AB - A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9-O-di-(E)-feruloyl-meso- 5,5-dimethoxysecoisolariciresinol (1) and 9,9-O-di-(E)-sinapinoyl-meso-5,5- dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L.obtusiloba stems. Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.

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New secoisolariciresinol derivatives from lindera obtusiloba stems and their neuroprotective activities

Abstract

All Science Journal Classification (ASJC) codes

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