A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9-O-di-(E)-feruloyl-meso- 5,5-dimethoxysecoisolariciresinol (1) and 9,9-O-di-(E)-sinapinoyl-meso-5,5- dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L.obtusiloba stems. Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry