New secoisolariciresinol derivatives from lindera obtusiloba stems and their neuroprotective activities

Ki Yong Lee, Soon Han Kim, Eun Ju Jeong, Jung Hyun Park, Seung Hyun Kim, Young Choong Kim, Sang Hyun Sung

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)

Abstract

A methanolic extract of Lindera obtusiloba (Lauraceae) stems significantly attenuated glutamate-induced oxidative stress in HT22 hippocampal cells. Two new secoisolariciresinol derivatives, characterized as 9,9-O-di-(E)-feruloyl-meso- 5,5-dimethoxysecoisolariciresinol (1) and 9,9-O-di-(E)-sinapinoyl-meso-5,5- dimethoxysecoisolariciresinol (2), were isolated, along with the known compound 9,9-O-di-(E)-feruloyl-meso-secoisolariciresinol (3), from the methanolic extract of L.obtusiloba stems. Compounds 1, 2, and 3 showed neuroprotective effects on glutamate-induced toxicity in HT22 cells.

Original languageEnglish
Pages (from-to)294-297
Number of pages4
JournalPlanta Medica
Volume76
Issue number3
DOIs
Publication statusPublished - 2010

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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