Abstract
The emergence of high-level resistance to ceftriaxone is giving rise to serious concern about absence of effective treatment options to cure gonococcal infections. Increasing the dosage regimen can be applied to ceftriaxone and azithromycin, but the emergence of high-level resistance has already been reported. Spectinomycin is another active drug but has low efficacy in the treatment of pharyngeal gonorrhoea. Conventional antibiotics could be introduced for gonococcal treatment, but they have some limitations, such as the absence of clinical trials and breakpoint. Combining antibiotics is another promising method to cure patients and to prevent the emergence of resistance. The most important strategy to maintain the efficacy of antibiotics is rapid detection and dissemination control of novel resistant isolate.
| Original language | English |
|---|---|
| Pages (from-to) | 243-256 |
| Number of pages | 14 |
| Journal | Expert Review of Anti-Infective Therapy |
| Volume | 14 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2016 Feb 1 |
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All Science Journal Classification (ASJC) codes
- Microbiology
- Microbiology (medical)
- Virology
- Infectious Diseases
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New treatment options for infections caused by increasingly antimicrobial-resistant Neisseria gonorrhoeae. / Lee, Hyukmin; Lee, Kyungwon; Chong, Yunsop.
In: Expert Review of Anti-Infective Therapy, Vol. 14, No. 2, 01.02.2016, p. 243-256.Research output: Contribution to journal › Review article
TY - JOUR
T1 - New treatment options for infections caused by increasingly antimicrobial-resistant Neisseria gonorrhoeae
AU - Lee, Hyukmin
AU - Lee, Kyungwon
AU - Chong, Yunsop
PY - 2016/2/1
Y1 - 2016/2/1
N2 - The emergence of high-level resistance to ceftriaxone is giving rise to serious concern about absence of effective treatment options to cure gonococcal infections. Increasing the dosage regimen can be applied to ceftriaxone and azithromycin, but the emergence of high-level resistance has already been reported. Spectinomycin is another active drug but has low efficacy in the treatment of pharyngeal gonorrhoea. Conventional antibiotics could be introduced for gonococcal treatment, but they have some limitations, such as the absence of clinical trials and breakpoint. Combining antibiotics is another promising method to cure patients and to prevent the emergence of resistance. The most important strategy to maintain the efficacy of antibiotics is rapid detection and dissemination control of novel resistant isolate.
AB - The emergence of high-level resistance to ceftriaxone is giving rise to serious concern about absence of effective treatment options to cure gonococcal infections. Increasing the dosage regimen can be applied to ceftriaxone and azithromycin, but the emergence of high-level resistance has already been reported. Spectinomycin is another active drug but has low efficacy in the treatment of pharyngeal gonorrhoea. Conventional antibiotics could be introduced for gonococcal treatment, but they have some limitations, such as the absence of clinical trials and breakpoint. Combining antibiotics is another promising method to cure patients and to prevent the emergence of resistance. The most important strategy to maintain the efficacy of antibiotics is rapid detection and dissemination control of novel resistant isolate.
UR - http://www.scopus.com/inward/record.url?scp=84957624350&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84957624350&partnerID=8YFLogxK
U2 - 10.1586/14787210.2016.1134315
DO - 10.1586/14787210.2016.1134315
M3 - Review article
C2 - 26690658
AN - SCOPUS:84957624350
VL - 14
SP - 243
EP - 256
JO - Expert Review of Anti-Infective Therapy
JF - Expert Review of Anti-Infective Therapy
SN - 1478-7210
IS - 2
ER -