New treatment options for infections caused by increasingly antimicrobial-resistant Neisseria gonorrhoeae

Hyukmin Lee, Kyungwon Lee, Yunsop Chong

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

The emergence of high-level resistance to ceftriaxone is giving rise to serious concern about absence of effective treatment options to cure gonococcal infections. Increasing the dosage regimen can be applied to ceftriaxone and azithromycin, but the emergence of high-level resistance has already been reported. Spectinomycin is another active drug but has low efficacy in the treatment of pharyngeal gonorrhoea. Conventional antibiotics could be introduced for gonococcal treatment, but they have some limitations, such as the absence of clinical trials and breakpoint. Combining antibiotics is another promising method to cure patients and to prevent the emergence of resistance. The most important strategy to maintain the efficacy of antibiotics is rapid detection and dissemination control of novel resistant isolate.

Original languageEnglish
Pages (from-to)243-256
Number of pages14
JournalExpert Review of Anti-Infective Therapy
Volume14
Issue number2
DOIs
Publication statusPublished - 2016 Feb 1

Fingerprint

Neisseria gonorrhoeae
Ceftriaxone
Anti-Bacterial Agents
Infection
Spectinomycin
Azithromycin
Gonorrhea
Therapeutics
Clinical Trials
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Microbiology (medical)
  • Virology
  • Infectious Diseases

Cite this

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abstract = "The emergence of high-level resistance to ceftriaxone is giving rise to serious concern about absence of effective treatment options to cure gonococcal infections. Increasing the dosage regimen can be applied to ceftriaxone and azithromycin, but the emergence of high-level resistance has already been reported. Spectinomycin is another active drug but has low efficacy in the treatment of pharyngeal gonorrhoea. Conventional antibiotics could be introduced for gonococcal treatment, but they have some limitations, such as the absence of clinical trials and breakpoint. Combining antibiotics is another promising method to cure patients and to prevent the emergence of resistance. The most important strategy to maintain the efficacy of antibiotics is rapid detection and dissemination control of novel resistant isolate.",
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New treatment options for infections caused by increasingly antimicrobial-resistant Neisseria gonorrhoeae. / Lee, Hyukmin; Lee, Kyungwon; Chong, Yunsop.

In: Expert Review of Anti-Infective Therapy, Vol. 14, No. 2, 01.02.2016, p. 243-256.

Research output: Contribution to journalReview article

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