Nitric Oxide Delivery Using Biocompatible Perfluorocarbon Microemulsion for Antibacterial Effect

Moonhyun Choi, Sohyeon Park, Kyungtae Park, Hyejoong Jeong, Jinkee Hong

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Nitric oxide (NO) participates in various physiological and pathophysiological processes, for example, as a cell messenger and as an antimicrobial agent of the cell-mediated immune response. The development of NO-releasing materials to carry and deliver NO for biomedical applications has gained immense attention. NO-releasing perfluorooctane (PFO) microemulsion (ME) has been prepared using a simple and time-saving method. Perfluorocarbon (PFC) liquids are halogen-substituted carbon nonpolar oils with enhanced NO gas dissolution capacity. The solubility of NO in PFC liquids is higher than that in water-based fluids. Liquid-gas solubility is governed by Henry's Law. The cytotoxicity of the NO-unloaded and NO-loaded PFO MEs toward human dermal fibroblast (HDF) was evaluated. The results showed that the NO-loaded PFO ME was highly biocompatible. On the other hand, at high concentrations the NO-releasing PFO ME accelerated the bacteria (Staphylococcus aureus) death unlike the NO-unloaded PFO ME. Hence, NO-releasing PFO MEs are suitable for biomedical applications such as wound healing and antibacterial agents.

Original languageEnglish
Pages (from-to)1378-1383
Number of pages6
JournalACS Biomaterials Science and Engineering
Volume5
Issue number3
DOIs
Publication statusPublished - 2019 Mar 11

Fingerprint

Fluorocarbons
Nitric oxide
Microemulsions
Nitric Oxide
Liquids
Solubility
Gases
Bactericides
Antimicrobial agents
Halogens
Fibroblasts
Cytotoxicity
Anti-Infective Agents
perfluorooctane
Bacteria
Oils
Dissolution
Carbon

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biomedical Engineering

Cite this

Choi, Moonhyun ; Park, Sohyeon ; Park, Kyungtae ; Jeong, Hyejoong ; Hong, Jinkee. / Nitric Oxide Delivery Using Biocompatible Perfluorocarbon Microemulsion for Antibacterial Effect. In: ACS Biomaterials Science and Engineering. 2019 ; Vol. 5, No. 3. pp. 1378-1383.
@article{97b5cbbd303d442da50db12bedc182d5,
title = "Nitric Oxide Delivery Using Biocompatible Perfluorocarbon Microemulsion for Antibacterial Effect",
abstract = "Nitric oxide (NO) participates in various physiological and pathophysiological processes, for example, as a cell messenger and as an antimicrobial agent of the cell-mediated immune response. The development of NO-releasing materials to carry and deliver NO for biomedical applications has gained immense attention. NO-releasing perfluorooctane (PFO) microemulsion (ME) has been prepared using a simple and time-saving method. Perfluorocarbon (PFC) liquids are halogen-substituted carbon nonpolar oils with enhanced NO gas dissolution capacity. The solubility of NO in PFC liquids is higher than that in water-based fluids. Liquid-gas solubility is governed by Henry's Law. The cytotoxicity of the NO-unloaded and NO-loaded PFO MEs toward human dermal fibroblast (HDF) was evaluated. The results showed that the NO-loaded PFO ME was highly biocompatible. On the other hand, at high concentrations the NO-releasing PFO ME accelerated the bacteria (Staphylococcus aureus) death unlike the NO-unloaded PFO ME. Hence, NO-releasing PFO MEs are suitable for biomedical applications such as wound healing and antibacterial agents.",
author = "Moonhyun Choi and Sohyeon Park and Kyungtae Park and Hyejoong Jeong and Jinkee Hong",
year = "2019",
month = "3",
day = "11",
doi = "10.1021/acsbiomaterials.9b00016",
language = "English",
volume = "5",
pages = "1378--1383",
journal = "ACS Biomaterials Science and Engineering",
issn = "2373-9878",
publisher = "American Chemical Society",
number = "3",

}

Nitric Oxide Delivery Using Biocompatible Perfluorocarbon Microemulsion for Antibacterial Effect. / Choi, Moonhyun; Park, Sohyeon; Park, Kyungtae; Jeong, Hyejoong; Hong, Jinkee.

In: ACS Biomaterials Science and Engineering, Vol. 5, No. 3, 11.03.2019, p. 1378-1383.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nitric Oxide Delivery Using Biocompatible Perfluorocarbon Microemulsion for Antibacterial Effect

AU - Choi, Moonhyun

AU - Park, Sohyeon

AU - Park, Kyungtae

AU - Jeong, Hyejoong

AU - Hong, Jinkee

PY - 2019/3/11

Y1 - 2019/3/11

N2 - Nitric oxide (NO) participates in various physiological and pathophysiological processes, for example, as a cell messenger and as an antimicrobial agent of the cell-mediated immune response. The development of NO-releasing materials to carry and deliver NO for biomedical applications has gained immense attention. NO-releasing perfluorooctane (PFO) microemulsion (ME) has been prepared using a simple and time-saving method. Perfluorocarbon (PFC) liquids are halogen-substituted carbon nonpolar oils with enhanced NO gas dissolution capacity. The solubility of NO in PFC liquids is higher than that in water-based fluids. Liquid-gas solubility is governed by Henry's Law. The cytotoxicity of the NO-unloaded and NO-loaded PFO MEs toward human dermal fibroblast (HDF) was evaluated. The results showed that the NO-loaded PFO ME was highly biocompatible. On the other hand, at high concentrations the NO-releasing PFO ME accelerated the bacteria (Staphylococcus aureus) death unlike the NO-unloaded PFO ME. Hence, NO-releasing PFO MEs are suitable for biomedical applications such as wound healing and antibacterial agents.

AB - Nitric oxide (NO) participates in various physiological and pathophysiological processes, for example, as a cell messenger and as an antimicrobial agent of the cell-mediated immune response. The development of NO-releasing materials to carry and deliver NO for biomedical applications has gained immense attention. NO-releasing perfluorooctane (PFO) microemulsion (ME) has been prepared using a simple and time-saving method. Perfluorocarbon (PFC) liquids are halogen-substituted carbon nonpolar oils with enhanced NO gas dissolution capacity. The solubility of NO in PFC liquids is higher than that in water-based fluids. Liquid-gas solubility is governed by Henry's Law. The cytotoxicity of the NO-unloaded and NO-loaded PFO MEs toward human dermal fibroblast (HDF) was evaluated. The results showed that the NO-loaded PFO ME was highly biocompatible. On the other hand, at high concentrations the NO-releasing PFO ME accelerated the bacteria (Staphylococcus aureus) death unlike the NO-unloaded PFO ME. Hence, NO-releasing PFO MEs are suitable for biomedical applications such as wound healing and antibacterial agents.

UR - http://www.scopus.com/inward/record.url?scp=85061936930&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85061936930&partnerID=8YFLogxK

U2 - 10.1021/acsbiomaterials.9b00016

DO - 10.1021/acsbiomaterials.9b00016

M3 - Article

AN - SCOPUS:85061936930

VL - 5

SP - 1378

EP - 1383

JO - ACS Biomaterials Science and Engineering

JF - ACS Biomaterials Science and Engineering

SN - 2373-9878

IS - 3

ER -