TY - JOUR
T1 - Nitric Oxide Delivery using Nanostructures and Its Biomedical Applications
AU - Choi, Yunseo
AU - Jeong, Hyejoong
AU - Park, Kyungtae
AU - Hong, Jinkee
N1 - Publisher Copyright:
© 2019 Korean Institute of Chemical Engineers. All rights reserved.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019
Y1 - 2019
N2 - − The discovery of nitric oxide (NO) as a major signaling molecule in a number of pathophysiological processes – vasodilation, immune response, platelet aggregation, woUnd repair, and cancer biology – has led to the development of various exogeneous NO delivery systems. However, the development of ideal delivery system for human body application is still left as a challenge due to its high reactivity and short half-life in physiological condition. In this article, an overview of several nano-structures as potential NO delivery system will be presented, along with their recent research results and biomedical applications. Nano-size delivery system has immense advantages compared to others due to its high surface-to-volume ratio and capability for surface modification; thus, it has been proven to be effective in delivering nitric oxide with enhanced performance. Through this novel nano-structure delivery system, we are expecting to achieve sustained release of nitric oxide within adequate range of concentration, which ensures desired drug effects at the target site. Among different nano-structures, in particular, nanoparticle, microemulsion and nanofilm will be reviewed and compared to each other in respect of nitric oxide release profile. The proposed nano-structures for exogeneous NO delivery have a biological significance in that it can be further utilized in diverse biomedical fields as a highly promising therapeutic method.
AB - − The discovery of nitric oxide (NO) as a major signaling molecule in a number of pathophysiological processes – vasodilation, immune response, platelet aggregation, woUnd repair, and cancer biology – has led to the development of various exogeneous NO delivery systems. However, the development of ideal delivery system for human body application is still left as a challenge due to its high reactivity and short half-life in physiological condition. In this article, an overview of several nano-structures as potential NO delivery system will be presented, along with their recent research results and biomedical applications. Nano-size delivery system has immense advantages compared to others due to its high surface-to-volume ratio and capability for surface modification; thus, it has been proven to be effective in delivering nitric oxide with enhanced performance. Through this novel nano-structure delivery system, we are expecting to achieve sustained release of nitric oxide within adequate range of concentration, which ensures desired drug effects at the target site. Among different nano-structures, in particular, nanoparticle, microemulsion and nanofilm will be reviewed and compared to each other in respect of nitric oxide release profile. The proposed nano-structures for exogeneous NO delivery have a biological significance in that it can be further utilized in diverse biomedical fields as a highly promising therapeutic method.
UR - http://www.scopus.com/inward/record.url?scp=85068705187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85068705187&partnerID=8YFLogxK
U2 - 10.9713/kcer.2019.57.3.305
DO - 10.9713/kcer.2019.57.3.305
M3 - Article
AN - SCOPUS:85068705187
VL - 57
SP - 305
EP - 312
JO - Korean Chemical Engineering Research
JF - Korean Chemical Engineering Research
SN - 0304-128X
IS - 3
ER -