Nitric oxide in liver diseases

Yasuko Iwakiri, Moon Young Kim

Research output: Contribution to journalReview article

78 Citations (Scopus)

Abstract

Nitric oxide (NO) and its derivatives play important roles in the physiology and pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of the effect of NO on the pathogenesis and progression of liver diseases are observed. In general, NO derived from endothelial NO synthase (eNOS) in liver sinusoidal endothelial cells (LSECs) is protective against disease development, while inducible NOS (iNOS)-derived NO contributes to pathological processes. This review addresses the roles of NO in the development of various liver diseases with a focus on recently published articles. We present here two recent advances in understanding NO-mediated signaling - nitrated fatty acids (NO2-FAs) and S-guanylation - and conclude with suggestions for future directions in NO-related studies on the liver.

Original languageEnglish
Article number1236
Pages (from-to)524-536
Number of pages13
JournalTrends in Pharmacological Sciences
Volume36
Issue number8
DOIs
Publication statusPublished - 2015 Aug 11

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology

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