Nitric oxide in liver diseases

Yasuko Iwakiri; Moon Young Kim

doi:10.1016/j.tips.2015.05.001

Nitric oxide in liver diseases

Yasuko Iwakiri, Moon Young Kim

Internal Medicine

Research output: Contribution to journal › Review article › peer-review

154 Citations (Scopus)

Abstract

Nitric oxide (NO) and its derivatives play important roles in the physiology and pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of the effect of NO on the pathogenesis and progression of liver diseases are observed. In general, NO derived from endothelial NO synthase (eNOS) in liver sinusoidal endothelial cells (LSECs) is protective against disease development, while inducible NOS (iNOS)-derived NO contributes to pathological processes. This review addresses the roles of NO in the development of various liver diseases with a focus on recently published articles. We present here two recent advances in understanding NO-mediated signaling - nitrated fatty acids (NO₂-FAs) and S-guanylation - and conclude with suggestions for future directions in NO-related studies on the liver.

Original language	English
Article number	1236
Pages (from-to)	524-536
Number of pages	13
Journal	Trends in Pharmacological Sciences
Volume	36
Issue number	8
DOIs	https://doi.org/10.1016/j.tips.2015.05.001
Publication status	Published - 2015 Aug 11

Bibliographical note

Funding Information:
The authors thank Dr Teruo Utsumi for his critical comments on the manuscript. This work was supported by grant R01DK082600 from the National Institutes of Health (Y.I.).

Publisher Copyright:
© 2015 Elsevier Ltd.

All Science Journal Classification (ASJC) codes

Toxicology
Pharmacology

Access to Document

10.1016/j.tips.2015.05.001

Cite this

@article{945ea039ca484fe7ac0feb6b55b4e433,

title = "Nitric oxide in liver diseases",

abstract = "Nitric oxide (NO) and its derivatives play important roles in the physiology and pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of the effect of NO on the pathogenesis and progression of liver diseases are observed. In general, NO derived from endothelial NO synthase (eNOS) in liver sinusoidal endothelial cells (LSECs) is protective against disease development, while inducible NOS (iNOS)-derived NO contributes to pathological processes. This review addresses the roles of NO in the development of various liver diseases with a focus on recently published articles. We present here two recent advances in understanding NO-mediated signaling - nitrated fatty acids (NO2-FAs) and S-guanylation - and conclude with suggestions for future directions in NO-related studies on the liver.",

author = "Yasuko Iwakiri and Kim, {Moon Young}",

note = "Funding Information: The authors thank Dr Teruo Utsumi for his critical comments on the manuscript. This work was supported by grant R01DK082600 from the National Institutes of Health (Y.I.). Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2015",

month = aug,

day = "11",

doi = "10.1016/j.tips.2015.05.001",

language = "English",

volume = "36",

pages = "524--536",

journal = "Trends in Pharmacological Sciences",

issn = "0165-6147",

publisher = "Elsevier Limited",

number = "8",

}

TY - JOUR

T1 - Nitric oxide in liver diseases

AU - Iwakiri, Yasuko

AU - Kim, Moon Young

N1 - Funding Information: The authors thank Dr Teruo Utsumi for his critical comments on the manuscript. This work was supported by grant R01DK082600 from the National Institutes of Health (Y.I.). Publisher Copyright: © 2015 Elsevier Ltd.

PY - 2015/8/11

Y1 - 2015/8/11

N2 - Nitric oxide (NO) and its derivatives play important roles in the physiology and pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of the effect of NO on the pathogenesis and progression of liver diseases are observed. In general, NO derived from endothelial NO synthase (eNOS) in liver sinusoidal endothelial cells (LSECs) is protective against disease development, while inducible NOS (iNOS)-derived NO contributes to pathological processes. This review addresses the roles of NO in the development of various liver diseases with a focus on recently published articles. We present here two recent advances in understanding NO-mediated signaling - nitrated fatty acids (NO2-FAs) and S-guanylation - and conclude with suggestions for future directions in NO-related studies on the liver.

AB - Nitric oxide (NO) and its derivatives play important roles in the physiology and pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of the effect of NO on the pathogenesis and progression of liver diseases are observed. In general, NO derived from endothelial NO synthase (eNOS) in liver sinusoidal endothelial cells (LSECs) is protective against disease development, while inducible NOS (iNOS)-derived NO contributes to pathological processes. This review addresses the roles of NO in the development of various liver diseases with a focus on recently published articles. We present here two recent advances in understanding NO-mediated signaling - nitrated fatty acids (NO2-FAs) and S-guanylation - and conclude with suggestions for future directions in NO-related studies on the liver.

UR - http://www.scopus.com/inward/record.url?scp=84938994243&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84938994243&partnerID=8YFLogxK

U2 - 10.1016/j.tips.2015.05.001

DO - 10.1016/j.tips.2015.05.001

M3 - Review article

C2 - 26027855

AN - SCOPUS:84938994243

SN - 0165-6147

VL - 36

SP - 524

EP - 536

JO - Trends in Pharmacological Sciences

JF - Trends in Pharmacological Sciences

IS - 8

M1 - 1236

ER -

Nitric oxide in liver diseases

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this