Nitric oxide in liver diseases

Yasuko Iwakiri, Moon Young Kim

Research output: Contribution to journalReview articlepeer-review

154 Citations (Scopus)


Nitric oxide (NO) and its derivatives play important roles in the physiology and pathophysiology of the liver. Despite its diverse and complicated roles, certain patterns of the effect of NO on the pathogenesis and progression of liver diseases are observed. In general, NO derived from endothelial NO synthase (eNOS) in liver sinusoidal endothelial cells (LSECs) is protective against disease development, while inducible NOS (iNOS)-derived NO contributes to pathological processes. This review addresses the roles of NO in the development of various liver diseases with a focus on recently published articles. We present here two recent advances in understanding NO-mediated signaling - nitrated fatty acids (NO2-FAs) and S-guanylation - and conclude with suggestions for future directions in NO-related studies on the liver.

Original languageEnglish
Article number1236
Pages (from-to)524-536
Number of pages13
JournalTrends in Pharmacological Sciences
Issue number8
Publication statusPublished - 2015 Aug 11

Bibliographical note

Funding Information:
The authors thank Dr Teruo Utsumi for his critical comments on the manuscript. This work was supported by grant R01DK082600 from the National Institutes of Health (Y.I.).

Publisher Copyright:
© 2015 Elsevier Ltd.

All Science Journal Classification (ASJC) codes

  • Toxicology
  • Pharmacology


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