Nitrous oxide synthase expression in placenta of preeclampsia

Chung No Lee, Sung Woon Chang, Namhoon Cho, Sang Ho Cho

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

To compare the expression of endothelial nitrous oxide synthase (e-NOS), which plays a major role in vasoconstriction, in preeclampsia with that in the normotensive placenta and to identify whether or not e-NOS actually influences the pathogenesis of preeclampsia, we have studied the distribution and intensity of the endothelial isoform of NOS expression in preeclampsia (n=121) and normal (n=14) pregnancies. Archival paraffin-embedded tissues were immunostained with a polyclonal e-NOS antibody. E-NOS was stained predominantly in the endothelial cells of the umbilical cord and along the surface of the villi, especially within the cytoplasms of the syncytiotrophoblasts with a granular and punctuated pattern, but not in the trophoblastic island or in the Intravillous capillaries. The degree of e-NOS expression in pregnancy-induced hypertension (PIH) was significantly lower than in normotensive placenta, and moreover In the patients lacking abruptio. The expression of e-NOS in preeclampsia has some correlation with patient age. In conclusion, the degree of e-NOS expression in cotyledon from PIH is far less than from control, it means a kind of hemodynamic alteration of the fetoplacental circulation in preeclampsia.

Original languageEnglish
Pages (from-to)532-538
Number of pages7
JournalJournal of Korean Medical Science
Volume12
Issue number6
DOIs
Publication statusPublished - 1997 Jan 1

Fingerprint

Nitrous Oxide
Pre-Eclampsia
Placenta
Pregnancy Induced Hypertension
Placental Circulation
Cotyledon
Umbilical Cord
Trophoblasts
Vasoconstriction
Islands
Paraffin
Protein Isoforms
Cytoplasm
Endothelial Cells
Hemodynamics
Pregnancy
Antibodies

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Lee, Chung No ; Chang, Sung Woon ; Cho, Namhoon ; Cho, Sang Ho. / Nitrous oxide synthase expression in placenta of preeclampsia. In: Journal of Korean Medical Science. 1997 ; Vol. 12, No. 6. pp. 532-538.
@article{a3d8ce146a20492094723c2a1f3b9658,
title = "Nitrous oxide synthase expression in placenta of preeclampsia",
abstract = "To compare the expression of endothelial nitrous oxide synthase (e-NOS), which plays a major role in vasoconstriction, in preeclampsia with that in the normotensive placenta and to identify whether or not e-NOS actually influences the pathogenesis of preeclampsia, we have studied the distribution and intensity of the endothelial isoform of NOS expression in preeclampsia (n=121) and normal (n=14) pregnancies. Archival paraffin-embedded tissues were immunostained with a polyclonal e-NOS antibody. E-NOS was stained predominantly in the endothelial cells of the umbilical cord and along the surface of the villi, especially within the cytoplasms of the syncytiotrophoblasts with a granular and punctuated pattern, but not in the trophoblastic island or in the Intravillous capillaries. The degree of e-NOS expression in pregnancy-induced hypertension (PIH) was significantly lower than in normotensive placenta, and moreover In the patients lacking abruptio. The expression of e-NOS in preeclampsia has some correlation with patient age. In conclusion, the degree of e-NOS expression in cotyledon from PIH is far less than from control, it means a kind of hemodynamic alteration of the fetoplacental circulation in preeclampsia.",
author = "Lee, {Chung No} and Chang, {Sung Woon} and Namhoon Cho and Cho, {Sang Ho}",
year = "1997",
month = "1",
day = "1",
doi = "10.3346/jkms.1997.12.6.532",
language = "English",
volume = "12",
pages = "532--538",
journal = "Journal of Korean Medical Science",
issn = "1011-8934",
publisher = "Korean Academy of Medical Science",
number = "6",

}

Nitrous oxide synthase expression in placenta of preeclampsia. / Lee, Chung No; Chang, Sung Woon; Cho, Namhoon; Cho, Sang Ho.

In: Journal of Korean Medical Science, Vol. 12, No. 6, 01.01.1997, p. 532-538.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nitrous oxide synthase expression in placenta of preeclampsia

AU - Lee, Chung No

AU - Chang, Sung Woon

AU - Cho, Namhoon

AU - Cho, Sang Ho

PY - 1997/1/1

Y1 - 1997/1/1

N2 - To compare the expression of endothelial nitrous oxide synthase (e-NOS), which plays a major role in vasoconstriction, in preeclampsia with that in the normotensive placenta and to identify whether or not e-NOS actually influences the pathogenesis of preeclampsia, we have studied the distribution and intensity of the endothelial isoform of NOS expression in preeclampsia (n=121) and normal (n=14) pregnancies. Archival paraffin-embedded tissues were immunostained with a polyclonal e-NOS antibody. E-NOS was stained predominantly in the endothelial cells of the umbilical cord and along the surface of the villi, especially within the cytoplasms of the syncytiotrophoblasts with a granular and punctuated pattern, but not in the trophoblastic island or in the Intravillous capillaries. The degree of e-NOS expression in pregnancy-induced hypertension (PIH) was significantly lower than in normotensive placenta, and moreover In the patients lacking abruptio. The expression of e-NOS in preeclampsia has some correlation with patient age. In conclusion, the degree of e-NOS expression in cotyledon from PIH is far less than from control, it means a kind of hemodynamic alteration of the fetoplacental circulation in preeclampsia.

AB - To compare the expression of endothelial nitrous oxide synthase (e-NOS), which plays a major role in vasoconstriction, in preeclampsia with that in the normotensive placenta and to identify whether or not e-NOS actually influences the pathogenesis of preeclampsia, we have studied the distribution and intensity of the endothelial isoform of NOS expression in preeclampsia (n=121) and normal (n=14) pregnancies. Archival paraffin-embedded tissues were immunostained with a polyclonal e-NOS antibody. E-NOS was stained predominantly in the endothelial cells of the umbilical cord and along the surface of the villi, especially within the cytoplasms of the syncytiotrophoblasts with a granular and punctuated pattern, but not in the trophoblastic island or in the Intravillous capillaries. The degree of e-NOS expression in pregnancy-induced hypertension (PIH) was significantly lower than in normotensive placenta, and moreover In the patients lacking abruptio. The expression of e-NOS in preeclampsia has some correlation with patient age. In conclusion, the degree of e-NOS expression in cotyledon from PIH is far less than from control, it means a kind of hemodynamic alteration of the fetoplacental circulation in preeclampsia.

UR - http://www.scopus.com/inward/record.url?scp=0031297013&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031297013&partnerID=8YFLogxK

U2 - 10.3346/jkms.1997.12.6.532

DO - 10.3346/jkms.1997.12.6.532

M3 - Article

VL - 12

SP - 532

EP - 538

JO - Journal of Korean Medical Science

JF - Journal of Korean Medical Science

SN - 1011-8934

IS - 6

ER -