Nitrous oxide synthase expression in placenta of preeclampsia

Chung No Lee, Sung Woon Chang, Nam Hoon Cho, Sang Ho Cho

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Abstract

To compare the expression of endothelial nitrous oxide synthase (e-NOS), which plays a major role in vasoconstriction, in preeclampsia with that in the normotensive placenta and to identify whether or not e-NOS actually influences the pathogenesis of preeclampsia, we have studied the distribution and intensity of the endothelial isoform of NOS expression in preeclampsia (n=121) and normal (n=14) pregnancies. Archival paraffin-embedded tissues were immunostained with a polyclonal e-NOS antibody. E-NOS was stained predominantly in the endothelial cells of the umbilical cord and along the surface of the villi, especially within the cytoplasms of the syncytiotrophoblasts with a granular and punctuated pattern, but not in the trophoblastic island or in the Intravillous capillaries. The degree of e-NOS expression in pregnancy-induced hypertension (PIH) was significantly lower than in normotensive placenta, and moreover In the patients lacking abruptio. The expression of e-NOS in preeclampsia has some correlation with patient age. In conclusion, the degree of e-NOS expression in cotyledon from PIH is far less than from control, it means a kind of hemodynamic alteration of the fetoplacental circulation in preeclampsia.

Original languageEnglish
Pages (from-to)532-538
Number of pages7
JournalJournal of Korean medical science
Volume12
Issue number6
DOIs
Publication statusPublished - 1997 Jan 1

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All Science Journal Classification (ASJC) codes

  • Medicine(all)

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