Nivolumab in NSCLC: Latest evidence and clinical potential

Raghav Sundar; Byoung Chul Cho; Julie R. Brahmer; Ross A. Soo

doi:10.1177/1758834014567470

Nivolumab in NSCLC: Latest evidence and clinical potential

Raghav Sundar, Byoung Chul Cho, Julie R. Brahmer, Ross A. Soo

Department of Internal Medicine

Research output: Contribution to journal › Review article › peer-review

163 Citations (Scopus)

Abstract

New insight on the interaction between the immune system and tumor has identified the programmed death-1/programmed death-1 ligand pathway to be a key player in evading host immune response. The immune checkpoint modulator, nivolumab (BMS-936558/ONO-4538), is the first PD-1 inhibitor to gain regulatory approval, for the treatment of patients with unresectable melanoma. This review will discuss results from early phase studies of nivolumab in solid tumors including non-small cell lung cancer (NSCLC) as well as studies of nivolumab in combination with chemotherapy, other immune modulators and molecular targeted therapy in patients with NSCLC.

Original language	English
Pages (from-to)	85-96
Number of pages	12
Journal	Therapeutic Advances in Medical Oncology
Volume	7
Issue number	2
DOIs	https://doi.org/10.1177/1758834014567470
Publication status	Published - 2015 Mar

Bibliographical note

Funding Information:
RS, BCC and RAS have no conflicts of interest to declare. JBR has received research funding from Merck and BMS, is a paid consultant for Merck and is a compensated advisory board member for BMS.

Funding Information:
RAS is supported by the National Research Foundation, Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative.

All Science Journal Classification (ASJC) codes

Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/1758834014567470

Cite this

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AU - Soo, Ross A.

N1 - Funding Information: RS, BCC and RAS have no conflicts of interest to declare. JBR has received research funding from Merck and BMS, is a paid consultant for Merck and is a compensated advisory board member for BMS. Funding Information: RAS is supported by the National Research Foundation, Singapore and the Singapore Ministry of Education under its Research Centres of Excellence initiative.

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Nivolumab in NSCLC: Latest evidence and clinical potential

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

UN SDGs

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