NMR Spectroscopy in Structural Genomics

Weontae Lee, Adelinda Yee, Cheryl H. Arrowsmith

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


NMR spectroscopy is an alternative method to X-ray crystallography for the structure determination of small to medium sized proteins (<25 kDa) in aqueous or micellar solutions. Recent progress in computational and experimental NMR techniques has improved the efficiency of biological NMR research [1-4]. Ever improving strategies for uniform and selective biosynthetic incorporation of stable isotopes (15N, 13C and 2H) into recombinant proteins combined with newer multidimensional (3-D and 4-D) heteronuclear NMR experiments allows one to resolve resonance overlap for larger proteins and complexes than ever before.

Original languageEnglish
Title of host publicationStructural Genomics and High Throughput Structural Biology
PublisherCRC Press
Number of pages12
ISBN (Electronic)9780849361432
ISBN (Print)9780824753351
Publication statusPublished - 2005 Jan 1

Bibliographical note

Publisher Copyright:
© 2006 by Taylor and Francis Group, LLC.

All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)


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