NMR studies on antitumor drug candidates, berberine and berberrubine

Young Wook Jeon, Jin Won Jung, Miran Kang, In Kwon Chung, Weontae Lee

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Berberine and berberrubine, which display antitumor activity, have also demonstrated distinct enzyme-poisoning activities by stabilizing topoisomerase II-DNA cleavable complexes. The protoberberine berberrubine differs in chemical structure with berberine at only one position, however, it shows a prominent activity difference from berberine. Solution structures of berberine and berberrubine determined by NMR spectroscopy are similar, however, the minor structural rearrangement has been observed near 19 methoxy or hydroxyl group. We suggest that the DNA cleavage activities of topoisomerase II poisons could be correlated with both chemical environments and minor structural change together with hydrophobicity of interacting side chains of drugs with DNA molecule.

Original languageEnglish
Pages (from-to)391-394
Number of pages4
JournalBulletin of the Korean Chemical Society
Volume23
Issue number3
DOIs
Publication statusPublished - 2002 Mar 20

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Berberine
Antineoplastic Agents
Nuclear magnetic resonance
Type II DNA Topoisomerase
Poisons
DNA
Hydrophobicity
Hydroxyl Radical
Nuclear magnetic resonance spectroscopy
Molecules
berberrubine
Enzymes
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Jeon, Young Wook ; Jung, Jin Won ; Kang, Miran ; Chung, In Kwon ; Lee, Weontae. / NMR studies on antitumor drug candidates, berberine and berberrubine. In: Bulletin of the Korean Chemical Society. 2002 ; Vol. 23, No. 3. pp. 391-394.
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NMR studies on antitumor drug candidates, berberine and berberrubine. / Jeon, Young Wook; Jung, Jin Won; Kang, Miran; Chung, In Kwon; Lee, Weontae.

In: Bulletin of the Korean Chemical Society, Vol. 23, No. 3, 20.03.2002, p. 391-394.

Research output: Contribution to journalArticle

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