TY - JOUR
T1 - No association for Chinese HBV-related hepatocellular carcinoma susceptibility SNP in other East Asian populations
AU - Sawai, Hiromi
AU - Nishida, Nao
AU - Mbarek, Hamdi
AU - Matsuda, Koichi
AU - Mawatari, Yoriko
AU - Yamaoka, Megumi
AU - Hige, Shuhei
AU - Kang, Jong Hon
AU - Abe, Koichi
AU - Mochida, Satoshi
AU - Watanabe, Masaaki
AU - Kurosaki, Masayuki
AU - Asahina, Yasuhiro
AU - Izumi, Namiki
AU - Honda, Masao
AU - Kaneko, Shuichi
AU - Tanaka, Eiji
AU - Matsuura, Kentaro
AU - Itoh, Yoshito
AU - Mita, Eiji
AU - Korenaga, Masaaki
AU - Hino, Keisuke
AU - Murawaki, Yoshikazu
AU - Hiasa, Yoichi
AU - Ide, Tatsuya
AU - Ito, Kiyoaki
AU - Sugiyama, Masaya
AU - Ahn, Sang H.
AU - Han, Kwang Hyub
AU - Park, Jun Y.
AU - Yuen, Man Fung
AU - Nakamura, Yusuke
AU - Tanaka, Yasuhito
AU - Mizokami, Masashi
AU - Tokunaga, Katsushi
N1 - Funding Information:
This study was supported by a grant-in-aid from the Ministry of Health, Labour, and Welfare of Japan (H23-kanen-005), and Japan Science and Technology Agency (09038024). We thank Dr. Minae Kawashima to giving us technical advices.
PY - 2012/6/19
Y1 - 2012/6/19
N2 - Background: A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.Results: We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.Conclusions: None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.
AB - Background: A recent genome-wide association study (GWAS) using chronic HBV (hepatitis B virus) carriers with and without hepatocellular carcinoma (HCC) in five independent Chinese populations found that one SNP (rs17401966) in KIF1B was associated with susceptibility to HCC. In the present study, a total of 580 HBV-derived HCC cases and 1351 individuals with chronic hepatitis B (CHB) or asymptomatic carrier (ASC) were used for replication studies in order to evaluate the reported association with HBV-derived HCC in other East Asian populations.Results: We did not detect any associations between rs17401966 and HCC in the Japanese cohorts (replication 1: OR = 1.09, 95 % CI = 0.82-1.43; replication 2: OR = 0.79, 95 % CI = 0.54-1.15), in the Korean cohort (replication 3: OR = 0.95, 95 % CI = 0.66-1.36), or in the Hong Kong Chinese cohort (replication 4: OR = 1.17, 95 % CI = 0.79-1.75). Meta-analysis using these cohorts also did not show any associations with P = 0.97.Conclusions: None of the replication cohorts showed associations between rs17401966 and HBV-derived HCC. This may be due to differences in the genetic diversity among the Japanese, Korean and Chinese populations. Other reasons could be the high complexity of multivariate interactions between the genomic information and the phenotype that is manifesting. A much wider range of investigations is needed in order to elucidate the differences in HCC susceptibility among these Asian populations.
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U2 - 10.1186/1471-2350-13-47
DO - 10.1186/1471-2350-13-47
M3 - Article
C2 - 22712471
AN - SCOPUS:84862303606
SN - 1471-2350
VL - 13
JO - BMC Medical Genetics
JF - BMC Medical Genetics
M1 - 47
ER -
